Computerized EEG as a Predictor of Drug Response in Treatment Resistant Schizophrenics

Turan, M.; Shapiro, Daniel; Schneider, Sid J.; Francis, Irene B.

doi:10.1097/00005053-198110000-00006

Cited by 49 publications

(19 citation statements)

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“…Moreover, preliminary evidence suggests that clozapine-induced EEG slowing might predict treatment response (Risby et al, 1995). This is in line with a number of earlier studies showing that computerized EEG analysis might be of value in predicting clinical response to psychopharmacological treatment (Saletu et al, 1988, Itil et al, 1981.…”

Section: Discussionsupporting

confidence: 90%

A Comparison of the Effects of Clozapine and Olanzapine on the EEG in Patients with Schizophrenia

Schuld¹,

Kuhn²,

Haack³

et al. 2000

Pharmacopsychiatry

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Clozapine is known to induce epileptic seizures and changes in EEG-patterns, including slowing and the appearance of epileptiform activity. Olanzapine, a new antipsychotic drug, shares many pharmacological and clinical properties with clozapine. However, in patients treated with olanzapine, no case of seizure induction has been reported so far, and the EEG has not been studied systematically. We examined the EEGs of patients with schizophrenia treated with either olanzapine (N = 9) or clozapine (N = 9) prior to medication and 3 to 7 weeks afterwards. Clozapine induced significant EEG slowing present in 78% of the patients, and definite epileptiform activity appeared in 33%. Olanzapine also induced significant EEG slowing, but less frequently (in 44% of the patients) and less pronounced than clozapine. Olanzapine had no significant effect an epileptiform activity, but in one patient, an isolated sharp/slow-wave complex was observed. These preliminary data suggest that olanzapine induces EEG slowing to a lower extent than clozapine. Olanzapine's possible effect an the seizure threshold deserves further attention.

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Section: Discussionsupporting

confidence: 90%

A Comparison of the Effects of Clozapine and Olanzapine on the EEG in Patients with Schizophrenia

Schuld¹,

Kuhn²,

Haack³

et al. 2000

Pharmacopsychiatry

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“…Furthermore, present results indicated that clinical response to treatment was correlated with pretreatment alpha-2 band power ( table 3 ), and suggested that higher EEG alpha-2 power in drug-naive patients was associated with poor response to neuroleptic treatment. This result was supported by those of previous studies regarding the relationships between pretreatment EEG activity and chronic treatment outcome [8,9] . Czobor and Volavka [9] reported a signifi cant negative correlation between baseline alpha activity and attention disturbance, and hypothesized that the effects of neuroleptics operating through normalization of attention vary depending on the pretreatment level of alpha activity (which is thought to refl ect attention disturbance).…”

Section: Discussionsupporting

confidence: 89%

“…Although no defi nitive conclusions could be derived from the results of these previous studies, patients who responded to neuroleptics tended to exhibit greater slowing after treatment than nonresponders [6,7] , and higher alpha or theta activity in nonmedicated patients tended to be associated with poor response to treatment [8][9][10] .…”

Section: Introductionmentioning

confidence: 97%

Individual Analysis of EEG Band Power and Clinical Drug Response in Schizophrenia

Kikuchi

Wada²,

Higashima³

et al. 2005

Neuropsychobiology

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The main purpose of this study was to investigate the relationship between short-term clinical outcome and changes in electroencephalogram (EEG) power after drug treatment in patients with schizophrenia, and also to compare two different methods for quantitative EEG analysis. EEG power analysis was performed by both conventional fixed frequency band and adjusted frequency band based on individual alpha frequency (IAF) in 16 drug-naive patients before and after drug administration. In the theta bands determined by both conventional fixed band and IAF methods, the EEG power after treatment was larger than that before treatment. In addition, there was a correlation between EEG power and clinical drug response evaluated by changes in BPRS score. With regard to this correlation, IAF methods showed no apparent advantage over methods using conventional fixed frequency bands. Conventional quantitative EEG analysis can still serve as a useful tool for the assessment of short-term outcome of drug treatment.

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“…There is also a strikingly consistent literature on the EEG and treatment response in schizophrenia, in which increased pre‐ and/or post‐treatment alpha‐wave EEG activity predicts response to antipsychotics in five out of the six studies we are aware of 143,144,145,146,147,148. There is enough replication here to justify further studies of PET and EEG of anti‐ psychotic drug response and to begin to evaluate this in terms of their potential clinical significance.…”

Section: Predicting Antipsychotic Drug Treatment Responsementioning

confidence: 54%

Do we have any solid evidence of clinical utility about the pathophysiology of schizophrenia?

et al. 2011

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Computerized EEG as a Predictor of Drug Response in Treatment Resistant Schizophrenics

Cited by 49 publications

References 0 publications

A Comparison of the Effects of Clozapine and Olanzapine on the EEG in Patients with Schizophrenia

A Comparison of the Effects of Clozapine and Olanzapine on the EEG in Patients with Schizophrenia

Individual Analysis of EEG Band Power and Clinical Drug Response in Schizophrenia

Do we have any solid evidence of clinical utility about the pathophysiology of schizophrenia?

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