Concentration Dependent Effects of Bovine Serum Albumin on Graphene Oxide Colloidal Stability in Aquatic Environment

Sun, Binbin; Zhang, Yinqing; Chen, Wei; Wang, Kunkun; Zhu, Lingyan

doi:10.1021/acs.est.7b06218

Cited by 80 publications

(59 citation statements)

References 55 publications

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“…Non-covalent interactions between proteins and GO have a critical influence on the nanomaterial dispersion stability in aqueous medium and lead to the coronation [ 53 ]. In addition, GO can absorb biomolecules by different mechanisms such as hydrogen bonding, hydrophobic interaction, π-π stacking, electrostatic and van der Waals interactions [ 9 , 54 ]. Sun et al (2018) demonstrated that BSA affects the GO colloidal stability in a nonlinear relationship with the BSA concentration, suggesting an integrated result of compressing electric double layers and steric repulsion induced by the interactions of BSA and GO [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

“…In addition, GO can absorb biomolecules by different mechanisms such as hydrogen bonding, hydrophobic interaction, π-π stacking, electrostatic and van der Waals interactions [ 9 , 54 ]. Sun et al (2018) demonstrated that BSA affects the GO colloidal stability in a nonlinear relationship with the BSA concentration, suggesting an integrated result of compressing electric double layers and steric repulsion induced by the interactions of BSA and GO [ 9 ]. More recently, it was also demonstrated that GO materials displaying different lateral sizes and functional groups exhibited different interactions with BSA in aqueous medium.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, it was demonstrated that BSA covalently bound to GO is a very interesting hybrid material for removal of uranium ions from seawater [ 7 ] and to produce filter membranes for metallic ion removal (i.e., AuCl 4 − , Co 2+ , Cu 2+ , Fe 2+ ) from aqueous solutions [ 8 ]. In addition, BSA has been considered as a model protein for assessing the fate of graphene oxide and other nanomaterials in the aquatic environment and colloidal nano-interactions with dissolved organic matter, such as humic substances [ 9 , 10 , 11 , 12 ]. Recently, Sun et al (2020) demonstrated that both protein structure and concentration are determinants for GO stability in aquatic environments, and that GO lateral size and solution chemistry are also crucial factors [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to Daphnia magna and Integration of the Datasets into the NanoCommons Knowledge Base

et al. 2020

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In this work, we evaluated the effect of protein corona formation on graphene oxide (GO) mixture toxicity testing (i.e., co-exposure) using the Daphnia magna model and assessing acute toxicity determined as immobilisation. Cadmium (Cd2+) and bovine serum albumin (BSA) were selected as co-pollutant and protein model system, respectively. Albumin corona formation on GO dramatically increased its colloidal stability (ca. 60%) and Cd2+ adsorption capacity (ca. 4.5 times) in reconstituted water (Daphnia medium). The acute toxicity values (48 h-EC50) observed were 0.18 mg L−1 for Cd2+-only and 0.29 and 0.61 mg L−1 following co-exposure of Cd2+ with GO and BSA@GO materials, respectively, at a fixed non-toxic concentration of 1.0 mg L−1. After coronation of GO with BSA, a reduction in cadmium toxicity of 110 % and 238% was achieved when compared to bare GO and Cd2+-only, respectively. Integration of datasets associated with graphene-based materials, heavy metals and mixture toxicity is essential to enable re-use of the data and facilitate nanoinformatics approaches for design of safer nanomaterials for water quality monitoring and remediation technologies. Hence, all data from this work were annotated and integrated into the NanoCommons Knowledge Base, connecting the experimental data to nanoinformatics platforms under the FAIR data principles and making them interoperable with similar datasets.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to Daphnia magna and Integration of the Datasets into the NanoCommons Knowledge Base

et al. 2020

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“…26 In the case of proteins, a 'protein corona' 27 is formed which may signicantly affect not only the protein structure and function but also the biological characteristics of GO. [28][29][30] The formation of the protein corona on the surface affects the fate of the designed nanomaterials. 31,32 Thus, a comprehensive study of the effect of surface modications of GO on its interaction with proteins is required for understanding and improving its biomedical efficacy.…”

Section: Introductionmentioning

confidence: 99%

“…12 GO-protein interactions have been studied, using techniques such as Circular Dichroism (CD), uorescence, UV-Vis spectroscopy, and Fourier transform Infra-Red spectroscopy (FTIR). 30,33,34 Using NMR spectroscopy, information about the dynamics of the protein and its individual residues can be obtained across a varying range of time scales. 35 This feature renders NMR a powerful spectroscopic technique for probing structural and dynamic perturbations in the protein backbone upon its interaction with GO.…”

Section: Introductionmentioning

confidence: 99%

Modulation of protein–graphene oxide interactions with varying degrees of oxidation

et al. 2020

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Surface Functionalization of Graphene‐Based Materials: Biological Behavior, Toxicology, and Safe‐By‐Design Aspects

et al. 2021

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drug delivery, bioimaging probes, antibacterial agents, and tissue engineering. [2] The advantage of GBMs over other nanomaterials (NMs) in biomedical application is their high specific surface area which allows high density functionalization and drug loading on both sides of the planar structure. [3] The π-conjugated system offers high capacity for GBMs to interact with various organic compounds with aromatic structures through π-π stacking during fabrication of graphene composites or for immobilization of biomolecules such as nucleic acids, peptides, antibodies, or other therapeutic substances. [4] The same properties may also raise concerns regarding the potential risk that GBMs may cause to human health through binding of key signaling molecules for example. GBMs may interact with biomolecules, changing the structure of protein or DNA or induce oxidative damage, and so on. [5] Therefore, prior to the widespread use of GBMs, it is imperative to evaluate their potential risk to environmental and human health and to establish a proactive approach for the safe design of these materials.In a recent review article, Fadeel et al. comprehensively examined the literature on the effects of GBMs on human health and the environment and gave an overview of the state-of-the-art of safety assessment of GBMs, highlighting the importance of The increasing exploitation of graphene-based materials (GBMs) is driven by their unique properties and structures, which ignite the imagination of scientists and engineers. At the same time, the very properties that make them so useful for applications lead to growing concerns regarding their potential impacts on human health and the environment. Since GBMs are inert to reaction, various attempts of surface functionalization are made to make them reactive. Herein, surface functionalization of GBMs, including those intentionally designed for specific applications, as well as those unintentionally acquired (e.g., protein corona formation) from the environment and biota, are reviewed through the lenses of nanotoxicity and design of safe materials (safe-by-design). Uptake and toxicity of functionalized GBMs and the underlying mechanisms are discussed and linked with the surface functionalization. Computational tools that can predict the interaction of GBMs behavior with their toxicity are discussed. A concise framing of current knowledge and key features of GBMs to be controlled for safe and sustainable applications are provided for the community.

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Concentration Dependent Effects of Bovine Serum Albumin on Graphene Oxide Colloidal Stability in Aquatic Environment

Cited by 80 publications

References 55 publications

Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to Daphnia magna and Integration of the Datasets into the NanoCommons Knowledge Base

Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to Daphnia magna and Integration of the Datasets into the NanoCommons Knowledge Base

Modulation of protein–graphene oxide interactions with varying degrees of oxidation

Surface Functionalization of Graphene‐Based Materials: Biological Behavior, Toxicology, and Safe‐By‐Design Aspects

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