Concentration of Ceruloplasmin in Plasma of Schizophrenic Patients

Scheinberg, I. Herbert; Morell, Anatol G.; Harris, Ruth S.; Berger, A. R.

doi:10.1126/science.126.3279.925

Cited by 48 publications

(5 citation statements)

References 8 publications

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“…Since Akerfeldt (1957) found an increased oxidase activity in serum of schizophrenics, numerous papers have been published about this subject (e. g. Abood, Gibbs & Gibbs (1957( ), Scheinberg & al. (1957, Abood (1959), Saunders & Chipkiewics (1959).…”

Section: Resultsmentioning

confidence: 99%

Serum and Cerebrospinal Fluid Proteins in Schizophrenia

Jensen¹,

Clausen²,

Osterman³

1964

Acta Psychiatr Scand

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Section: Resultsmentioning

confidence: 99%

Serum and Cerebrospinal Fluid Proteins in Schizophrenia

Jensen¹,

Clausen²,

Osterman³

1964

Acta Psychiatr Scand

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“…If this slowness is due to a ratelimiting step relatively independent ofsubstrate structure, then it is improbable that rates with any substrates would be much greater. The possibility, however, of physiologically significant enzyme properties of caeruloplasmin cannot be discounted, as its concentration in human plasma is high, averaging 24mg/ lOOml according to Scheinberg et al (1957), and there is evidence for physiological oxidation of Fe2+ by caeruloplasmin (Roeser et al, 1969;Osaki & Johnson, 1969).…”

Section: Discussionmentioning

confidence: 99%

A method for obtaining linear reciprocal plots with caeruloplasmin and its application in a study of the kinetic parameters of caeruloplasmin substrates

Young

Curzon

1972

Biochemical Journal

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1. The curved plots of 1/v against 1/[S] obtained when caeruloplasmin oxidizes NN-dimethyl-p-phenylenediamine were investigated. The first free-radical oxidation product of caeruloplasmin oxidation of NN-dimethyl-p-phenylenediamine is required for curvature, as straight-line plots were obtained when activities were measured either before appreciable free-radical product had appeared or in the presence of ascorbate, which reduced it back to NN-dimethyl-p-phenylenediamine. 2. In the presence of ascorbate linear reciprocal-plots were obtained with all of the 37 substrates tested. V(max.) values varied over only an eightfold range and those for the 20 p-amino compounds over only a twofold range. K(m) values, however, varied over a 10(4)-fold range. The small range of V(max.) values indicates that the rate-limiting step in caeruloplasmin action is relatively independent of the nature of the substrate. K(m) values suggest that substrates bind primarily by ring electrons, although certain side-chain groups increased the K(m) in a manner unrelated to likely changes of ring-electron densities. A mechanism involving repulsion between negative charges on the substrate and the enzyme was supported by the variation of the K(m) of 5-hydroxyindol-3-ylacetic acid with pH.

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“…In einer in Science erschienenen Publikation sprach Akerfeldt [5] von der "possibility of using this color reaction as a diagnostic test in mental illness". Diese Formulierung musste zur damaligen Zeit Widerspruch provozieren, und Scheinberg und Mitarbeiter hielten es für notwendig, im Rahmen ihrer Replikation der Er-gebnisse Akerfeldts die Bedeutung des Coeruloplasmins für die Schizophrenie insgesamt infrage zu stellen, da einige Patienten normale Coeruloplasminspiegel hatten [137]. Zudem wurden im weiteren Verlauf zunehmend immunologisch basierte Messungen durchgeführt, die im Gegensatz zu den enzymatischen Reaktionen in der Regel keine erhöhten Coeruloplasmin-Konzentrationen zeigten.…”

Section: Abstract !unclassified

Die Bedeutung des Coeruloplasmins für die Differenzialdiagnose neuropsychiatrischer Störungen

Connemann

Schönfeldt‐Lecuona²,

Maxon³

et al. 2010

Fortschr Neurol Psychiatr

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The blue copper protein ceruloplasmin has been of interest to psychiatrists for decades following Heilmeyer's observation of elevated serum copper levels in schizophrenic patients. Immunoturbidimetry, however, does not yield elevated serum ceruloplasmin concentrations in schizophrenia while ceruloplasmin-related oxidase activity appears to be elevated in patients with schizophrenia and reduced in patients with Alzheimer's disease. Low serum concentrations of immuno-turbidimetrically measured ceruloplasmin, and of oxidase activity, are typical of Wilson's disease, Menkes' disease, and aceruloplasminemia, three familial neurodegenerative disorders of pronounced variability, with regard to both genotype and phenotype. Especially patients with Wilson's disease may exhibit behavioural symptoms only over a long period. Heterozygous carriers of Wilson's disease and aceruloplasminaemia may have low serum ceruloplasmin concentrations; they will not develop somatic symptoms, but the significance of these carrier states, or of "hypoceruloplasminaemia", with regard to mental disorders is unknown.

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Concentration of Ceruloplasmin in Plasma of Schizophrenic Patients

Cited by 48 publications

References 8 publications

Serum and Cerebrospinal Fluid Proteins in Schizophrenia

Serum and Cerebrospinal Fluid Proteins in Schizophrenia

A method for obtaining linear reciprocal plots with caeruloplasmin and its application in a study of the kinetic parameters of caeruloplasmin substrates

Die Bedeutung des Coeruloplasmins für die Differenzialdiagnose neuropsychiatrischer Störungen

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