Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate

Steinborn, Barbara; Żarowski, Marcin; Winczewska‐Wiktor, Anna; Wójcicka, Marlena; Młodzikowska-Albrecht, Justyna; Losy, Jacek

doi:10.1016/j.pharep.2014.06.005

Cited by 21 publications

(20 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Partial seizures without impairment of consciousness with simple symptomatology and possessing an origin in neocortex is a subclass of focal epileptic seizures, whereas partial seizures with impairment of consciousness with complex symptomatology and originating in old cortical structures of the temporal lobe (or for some cases in orbitofrontal cortex) is another type (1,2). When considering generalised seizures, there is an onset recorded simultaneously in both cerebral hemispheres (3).…”

Section: Introductionmentioning

confidence: 99%

“…This complexity of genetical approach is directing researchers to analyse processes underlying epilepsy in area of biological-pathway-based approach. Besides, epilepsy is not defined as a single disorder but rather a group of syndromes with a variety of underlying diseases, and also neurotransmitter distributions or other metabolic problems are supposed to involve in epileptogenesis (1)(2)(3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms

Alyu

Dikmen

2016

Acta Neuropsychiatr.

133

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms

Alyu

Dikmen

2016

Acta Neuropsychiatr.

133

View full text Add to dashboard Cite

show abstract

“…Previous reports have shown that as epilepsy treatment progressed, the levels of neuroinflammatory mediators decrease. 16,31,32 The reason for the obtained result in the present study was presumed to be the difference in the commonly used antiepileptic drugs between humans and dogs. In human-based epilepsy studies that reported a decrease in inflammatory mediators with the progression of epilepsy treatment, valproic acid was mainly administered.…”

Section: Correlation Of Serum Hmgb1 Concentration With the Durationmentioning

confidence: 59%

“…In human-based epilepsy studies that reported a decrease in inflammatory mediators with the progression of epilepsy treatment, valproic acid was mainly administered. 16,32 Anti-inflammatory effect of valproic acid has been reported; however, there are no reports of the anti-inflammatory effects of phenobarbital and KBr, which are commonly administered One recent study demonstrated that serum HMGB1 concentration increases immediately after a generalized convulsive seizure and remains elevated for 6 hours. 34 The times for each acquired serum sample after seizure varied in this study and thus, it is possible that variations in collection timing influenced the analysis of the correlation between seizure frequency and serum HMGB1 level.…”

Section: Correlation Of Serum Hmgb1 Concentration With the Durationmentioning

confidence: 99%

Evaluation of serum high‐mobility group box 1 concentration in dogs with epilepsy: A case‐control study

Koo

Kim

Yun

et al. 2020

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background: High-mobility group box 1 (HMGB1) is a key mediator of neuroinflammation and there are increased HMGB1 levels in laboratory animal models of epilepsy and human patients with epilepsy. Objectives: To determine serum HMGB1 levels in dogs with epilepsy. Animals: Twenty-eight epileptic dogs, 12 dogs with nonepileptic brain diseases, and 26 healthy dogs. Methods: In this case-control study, serum HMGB1 concentrations were estimated using the canine-specific enzyme-linked immunosorbent assay kit. Diagnosis of dogs with epilepsy was based on medical history, physical and neurological examination findings, laboratory test results, magnetic resonance image, and cerebrospinal fluid analysis. Results: Serum HMGB1 levels were significantly higher in epileptic dogs (median = 0.41 ng/mL; range, 0.03-5.28) than in healthy dogs (median = 0.12 ng/mL; range, 0.02-1.45; P = .002). In contrast, serum HMGB1 levels of dogs with non-epileptic brain diseases (median = 0.19 ng/mL; range, 0.03-1.04) were not significantly increased compared to those of healthy dogs (P = .12). Regarding idiopathic epilepsy, dogs with an epilepsy course of >3 months showed a higher serum HMGB1 concentration (median = 0.87 ng/mL; range, 0.42-2.88) than those with that of ≤3 months (median = 0.26 ng/mL; range, 0.03-0.88; P = .02). Conclusions and Clinical Importance: Serum HMGB1 could be a biomarker of epilepsy.

show abstract

“…IL-6 is an early-stage inflammatory factor, and despite its protective effect on brain tissue, long-term overexposure will not only result in the augmentation of neuroglia, but also cause variations in tissue morphology, thus aggravating epilepsy ( 18 ). IL-2 can regulate the balance of lymphocytes, shorten epilepsy latency and decrease the threshold value for extending the onset of epileptic discharge ( 19 ). This study showed that serum HMGB-1 levels were positively correlated with the levels of IL-2 and IL-6.…”

Section: Discussionmentioning

confidence: 99%

The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels

Zhou

Wang

et al. 2017

Exp Ther Med

View full text Add to dashboard Cite

This study evaluated the efficacy of gastrodin in combination with folate (FOL) and vitamin-B12 (V-B12) on patients with epilepsy after stroke (EAS) and its effect on high-mobility group protein B1 (HMGB-1), interleukin-1 (IL-1), and IL-6 serum levels. The clinical data of 92 EAS patients admitted for treatment between April, 2014 and March, 2016 were collected. These patients were randomly divided into control and observation groups (n=46 each) using computer software. Patients in the control group were administered only regular antiepileptic drugs, whereas observation group patients also received a combination of gastrodin, FOL and V-B12. After treatment, we compared efficacy, frequency of epileptic seizure, and Montreal cognitive assessment (MoCA) scores. Serum homocysteine (HCY), FOL and V-B12 levels were detected 3 months later. Enzyme-linked immunosorbent assay (ELISA) was used to detect changes in serum HMGB-1, IL-2 and IL-6 levels at one day before treatment and on the 7th, 21st, 30th and 90th days after treatment. Pearson's correlation coefficient was utilized to analyze the correlations of HMGB-1 with IL-2 and IL-6. The total treatment effectiveness rate was 95.65% in the observation group, which was significantly higher than the control group (73.91%, p<0.05). Epileptic seizure frequency and MoCA scores significantly improved in the observation group (p<0.05). Serum HCY levels were significantly lower, whereas FOL and V-B12 serum levels were significantly higher, at 3 months post-treatment start in the observation group relative to control group (p<0.05). After treatment, serum HMGB-1, IL-2 and IL-6 levels progressively decreased over time in both groups, but observation group levels were significantly lower than in control group (p<0.05). Pearson's correlation coefficient analysis showed that HMGB-1 levels were positively correlated with IL-2 and IL-6 levels. A combination of gastrodin, FOL and V-B12 for EAS can significantly improve inflammatory response symptoms, decrease HCY levels, and increase FOL and V-B12 levels in serum while effectively controlling epileptic seizures, thus exhibiting relatively better clinical efficacy. Therefore, this combination treatment is worthy of being promoted in clinical practice.

show abstract

Concentration of Il-1β, Il-2, Il-6, TNFα in the blood serum in children with generalized epilepsy treated by valproate

Cited by 21 publications

References 14 publications

Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms

Inflammatory aspects of epileptogenesis: contribution of molecular inflammatory mechanisms

Evaluation of serum high‐mobility group box 1 concentration in dogs with epilepsy: A case‐control study

The efficacy of gastrodin in combination with folate and vitamin B12 on patients with epilepsy after stroke and its effect on HMGB-1, IL-2 and IL-6 serum levels

Contact Info

Product

Resources

About