CONCENTRATIONS OF PREGNANCY-SPECIFIC Β1-Glycoprotein IN MATERNAL BLOOD IN NORMAL PREGNANCY AND IN INTRAUTERINE GROWTH RETARDATION

A comparative study of the clinical use of four placental proteins in the third trimester

“…Maternal circulating levels of hCG, hPL, SP1 and PP5 at 36-40 weeks gestation in 54 subjects with a growth retarded fetus (< 10th centile of population range) compared with 468 subjects delivering a fetus of normal weight present findings confirm numerous previous investigation. Opinion is divided on this subject, observations to the effect that low maternal hPL some workers (including our own group) having levels are associated with intrauterine growth shown an association [4,7,12,23,25], while retardation [13]. Surprisingly, SP1 levels were others have not [8].…”

“…Serum was stored at -20 °C until assay. The measurement of hCG, hPL, SP1 and PP5 was performed by radioimmunoassay as described previously [6,7,12,16]. The results were analysed by calculation of means and standard deviations after logarithmic transformation of the data: The latter were used for comparison of sub-population by Student's t-test.…”

“…Notable among these are pregnancy specific ß l glycoprotein (SP1) and placental protein 5 (PP5). Maternal serum levels of SP1 are related to the delivered weight of the infant and can be used to identify intrauterine growth retardation [4,7,14,23,25,26]. Placental protein 5 is much less efficient in this respect [17] but has great potential interest because of its possible association with the coagulation system [16,20] and the fact that elevated levels may be associated with pre-eclampsia [11], placental abruption [21] and premature labor [22].…”

Pregnancy-specific β1-glycoprotein (SP1) in serum from women with pregnancies complicated by intrauterine growth retardation

“…GORDON etal. [8] reported that during pregnancy weeks 31 to 40 more than 70% of women with IUGR infants had SPj concentrations below the 10th percentile of the reference range. TOWLER et al [28] found the predictive value of 8Ρχ levels below a 95 % reference range for detection of IUGR to be 60% during the last trimester.…”

Radioimmunoassay of SP1(Pregnancy-specificβ1-glycoprotein) in maternal blood and in amniotic fluid in normal and pathologic pregnancies

“…Recently the occurrence of a high molecular weight variant was proposed [25]. The protein is synthesized in the syncytiotrophoblast of the placenta [8,18] and secreted into the maternal blood in increasing concentrations äs pregnancy proceeds [5,6,16,21,29,31]. Its detection is possible äs early äs 18 days W ra et al, SPi in normal and pathologic pregnancies l Materials and methods 1.1 Blood samples were taken from healthy pr gnant women and from hospitalized and outpatients.…”