Concentrations of serum Amyloid‐a (SAA) and haptoglobin (HP) as parameters of inflammatory diseases in cattle

Alsemgeest, S.P.M.; Kalsbeek, H.C.; Wensing, Th.; Koeman, J. P.; Ederen, A.M. van; Gruys, E.

doi:10.1080/01652176.1994.9694410

Cited by 186 publications

(176 citation statements)

References 20 publications

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“…Hp is the most sensitive marker of inflammation in cows [2,7,8]. Since most of the cows suffering from amyloidosis examined in the present study showed increases in both SAA and Hp levels, it was thought that the increase in SAA level was mainly caused by concomitant inflammation.…”

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confidence: 88%

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Serum Amyloid A and Haptoglobin Levels in Bovine Amyloidosis

Takahashi

Uzuka

Tanabe

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. Serum amyloid A (SAA) and haptoglobin (Hp) levels were determined in 25 cows suffering from amyloidosis. SAA levels in cows with amyloidosis ranged between < 0.3 and 225.8 µg/ml, with a median level of 105.1 µg/ml, and Hp levels ranged between < 20 and 1860 µg/ml, with a median level of 950 µg/ml. These levels were significantly higher than the levels observed in healthy cows (SAA levels ranged from < 0.3 to 13.5 µg/ml, with median of 1.4 µg/ml, and Hp levels were undetectable in all cases), but were not significantly different from the levels observed in control cows with chronic inflammation. There was a significant correlation between SAA and Hp levels in cows with chronic inflammation , but not in cows with amyloidosis. It was concluded that the serum SAA levels in cows with amyloidosis might be changed by some factor other than inflammation. KEY WORDS: amyloidosis, haptoglobin, serum amyloid A.

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confidence: 88%

“…SAA levels in cows with various diseases have been reported only recently [2,3,5,8,9], but the levels are not routinely measured yet, and there has been only one publication on the determination of the serum SAA level in a cow with amyloidosis [1].…”

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confidence: 99%

Serum Amyloid A and Haptoglobin Levels in Bovine Amyloidosis

Takahashi

Uzuka

Tanabe

et al. 2007

The Journal of Veterinary Medical Science

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“…Serum amyloid A (SAA) is a sensitive APP in cattle [1,8,11,13,24]. SAA has been shown to reflect the severity of mastitis; cows with clinical mastitis had almost 100-fold levels of SAA in serum and milk compared with healthy cows [5].…”

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confidence: 99%

Serum amyloid A and TNF? in serum and milk during experimental endotoxin mastitis

2004

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-A cross-over study was conducted to investigate the effect of intramammarily infused lipopolysaccharide (LPS) on the acute phase reaction in early (EL) and in late (LL) lactation. Nine cows received intramammary injections of 100 µg of Escherichia coli 0111:B4 LPS during EL and LL. The severity of each cows systemic and local signs and change in milk appearance were recorded and scored throughout the experiment. Systemic and local signs were found to be more serious in EL cows. Tumor necrosis factor α (TNFα) was detected in milk but not in serum. Serum amyloid A (SAA) concentrations increased both in serum and in milk. The milk TNFα concentrations peaked at 8 h post-challenge (PC). SAA concentrations started to increase at 8 h PC, and peak concentrations were seen at 32 and 48 h PC in milk and serum, respectively. The milk TNFα and SAA seemed to be correlated, being on average higher in EL. Serum SAA concentration was not correlated with milk TNFα or SAA, nor with the severity of local or systemic signs, but was correlated with changes in milk appearance. LPS / mastitis / dairy cow / SAA / TNFα

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“…On the other hand, some studies noted that the concentrations of SAA and haptoglobin remained at normal ranges during experimentally created bacterial and aseptic infections (ALSEMGEEST et al, 1994;NAKAGAWA et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Detection of serum amyloid-A concentration in the calf clinically diagnosed with pneumonia, enteritis and pneumoenteritis

2016

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The aim of this study is to determine serum amyloid-A (SAA) concentration in the cases of pneumonia, pneumoenteritis, and enteritis which are frequently encountered in calves in veterinary medicine. Although a great deal of experimental studies has been conducted in this field, studies on naturally infectedcalves are quite few. Eighty calves at the age of 0-6 months were used in the study and the calves were divided into four groups. Due to the clinical examination, the calves diagnosed with pneumonia (Group P; n=20), with pneumoenteritis (Group PE; n=20) and with enteritis (Group E; n=20) vitelos com a idade de 0-6 meses de idade foram utilizados no estudo e os animais foram divididos em quatro grupos. Devido ao exame clínico, os bezerros diagnosticados com pneumonia (Grupo P; n=20), com pneumoenterites (Grupo PE; n=20) e com enterite (Grupo E; n=20) formaram o grupo de doença, como as saudáveis, formando o grupo controle (Grupo C; n=20). Após as temperaturas corporais de todos os bezerros, foram tomadas amostras de sangue que foram obtidas de veia jugular para medições hematológicas e bioquímicas. Como hematológica, glóbulos brancos (WBC), glóbulos vermelhos (RBC), hemoglobina (Hb) e hematócrito (HCT) foram realizados em Hematologia Veterinária Analyzer. O soro amilóide-A (SAA), a interleucina 1 (IL-1β), interleucina 6 (IL-6), fator de necrose tumoral (TNF-α) medidas de concentração foram efectuadas com um leitor de ELISA, utilizando kits comerciais. Aspartato aminotransferase (AST), alanina aminotransferase (ALT), albumina (ALB), bilirrubina total (T. Bil), proteína total (TP), gama glutamiltransferase (GGT), ureia (BUN) às medições das concentrações foram realizadas em auto-analisador por utilizandos kits comerciais. Em todos os grupos de doenças (P, PE,

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Concentrations of serum Amyloid‐a (SAA) and haptoglobin (HP) as parameters of inflammatory diseases in cattle

Cited by 186 publications

References 20 publications

Serum Amyloid A and Haptoglobin Levels in Bovine Amyloidosis

Serum Amyloid A and Haptoglobin Levels in Bovine Amyloidosis

Serum amyloid A and TNF? in serum and milk during experimental endotoxin mastitis

Detection of serum amyloid-A concentration in the calf clinically diagnosed with pneumonia, enteritis and pneumoenteritis

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