Concentrations of Sialyloligosaccharides in Bovine Colostrum and Milk during the Prepartum and Early Lactation

Nakamura, Tadashi; Kawase, H.; Kimura, Kazumasa; Watanabe, Yoko; Ohtani, Masayuki; Arai, Ikichi; Urashima, Tadasu

doi:10.3168/jds.s0022-0302(03)73715-1

Cited by 135 publications

(165 citation statements)

References 31 publications

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“…A suitable source of 3 0 -SL might be bovine colostrum, which contains up to 1 g/l of this saccharide. 19) Of the colostrum sialyl oligosaccharides determined in this study, LSTc was present at the highest concentration. In this saccharide, Neu5Ac is linked to a nonreducing galactose in the lacto-N-neotetraose (LNnT) unit via an 2-6 linkage.…”

Section: Resultsmentioning

confidence: 99%

Sialyl Oligosaccharides of Human Colostrum: Changes in Concentration during the First Three Days of Lactation

Asakuma

Akahori

Kimura

et al. 2007

Bioscience, Biotechnology, and Biochemistry

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Section: Resultsmentioning

confidence: 99%

Sialyl Oligosaccharides of Human Colostrum: Changes in Concentration during the First Three Days of Lactation

Asakuma

Akahori

Kimura

et al. 2007

Bioscience, Biotechnology, and Biochemistry

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“…Furthermore, the role of sialic acid in binding of Ca to ganglioside which has a great effect on the function of nervous tissue cannot be overemphasized (Schaur and Kamerling, 1997). Interestingly, one assessment of bovine colostrum and milk between prepartum and early lactation confirmed the abundance of sialyl oligosaccharides in bovine milk and suggested that bovine milk can be a potential source of sialyloligosaccharides as additives in the food or pharmaceutical industries (Nakamura et al, 2003).…”

Section: Brain Developmentmentioning

confidence: 87%

Classification, Structure, and Bioactive Functions of Oligosaccharides in Milk

Mijan¹,

Lee²,

Kwak³

2011

Korean Journal for Food Science of Animal Resources

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Milk oligosaccharides are the complex mixture of six monosaccharides namely, D-glucose, D-galactose, N-acetyl-glucosamine, N-acetyl-galactosamine, L-fucose, and N-acetyl-neuraminic acid. The mixture is categorized as neutral and acidic classes. Previously, 25 oligosaccharides in bovine milk and 115 oligosaccharides in human milk have been characterized. Because human intestine lacks the enzyme to hydrolyze the oligosaccharide structures, these substances can reach the colon without degradation and are known to have many health beneficial functions. It has been shown that this fraction of carbohydrate can increase the bifidobacterial population in the intestine and colon, resulting in a significant reduction of pathogenic bacteria. The role of milk oligosaccharides as a barrier against pathogens binding to the cell surface has recently been demonstrated. Milk oligosaccharides have the potential to produce immuno-modulation effects. It is also well known that oligosaccharides in milk have a significant influence on intestinal mineral absorption and in the formation of the brain and central nervous system. Due to its structural resemblance, bovine milk is considered to be the most potential source of oligosaccharides to produce the same effect of oligosaccharides present in human milk. This review describes the characteristics and potential health benefits of milk oligosaccharides as well as the prospects of oligosaccharides in bovine milk for use in functional foods.

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“…There is a diff erence between human and cow in the ratio of 3'-SL to 6'-SL, in that 6'-SL predominates over 3'-SL in human milk/colostrum. The levels of the acidic oligosaccharides were maximal immediately after parturition, rapidly decreasing by 48 h post-partum (Nakamura et al, 2003).…”

Section: Milk Oligosaccharides Of the Cow And Other Domestic Farm Animentioning

confidence: 95%

“…These results support the notion of anti-infl ammatory eff ects of acidic human milk oligosaccharides. Nakamura et al (2003) and Gopal & Gill (2000) stated that bovine colostrum collected immediately after parturition contains more than 1 g/L of oligosaccharides, but the mature milk contains only small amounts. Although 25 bovine oligosaccharides structures isolated from the colostrum have been completely characterized (Table 2), as many as 39 oligosaccharides have been detected using a combination of nanoelectrospray Fourier transform ion cyclotron resonance (nESI-FTICR) mass spectrometry and matrix-assisted laser desorption/ ionization Fourier transform ion cyclotron resonance (MALDI-FTICR) mass spectrometry (Tao et al, 2008).…”

Section: Immuno -Modulating Eff Ectmentioning

confidence: 99%

Oligosaccharides in Milk: Their Benefits and Future Utilization

Urashima¹,

Taufik²

2010

medpet

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The percentage of carbohydrate in the milk/colostrum of the mammalian is range from trace to over 10%, of which disaccharide lactose (Gal(β1-4)Glc) is usually constitutes the major part. Apart from the lactose (Gal(β1-4)Glc; Gal, D-galactose; Glc, D-glucose), the rest of carbohydrate components is composed of variety of sugars, commonly named as milk oligosaccharides. Human mature milk and colostrum contain 12 ~ 13 g/l and 22 ~ 24 g/l of oligosaccharides, respectively. In contrast, bovine colostrum contains more than 1 g/l oligosaccharides and this concentration rapidly decreases after 48 hr post partum. Most of human milk oligosaccharides (HMO) are resistant to digestion and absorption within the small intestine. Therefore they can reach the infant colon, where they can act as prebiotics that stimulate the growth of benefi cial microorganisms such as various species of Bifi dobacterium. They can also act as receptor analogues that inhibit the a achment of pathogenic microorganisms to the infant's colonic mucosa. A small part of the milk oligosaccharides is absorbed intact into the circulation and it has been hypothesized that these may act as immunomodulators. Generally, the bovine milk oligosaccharides are believed not to be absorbed by human adults or infants, thus making them available to be utilized as prebiotics or anti-infection materials. The colostrum of cows and other domestic farm animals is a potential source of free oligosaccharides, and oligosaccharides isolated from these natural sources can be utilized as functional foods or animal feedstuff s on the industrial scale.Key words: milk, oligosaccharides, prebiotic, Bifi dobacterium * Corresponding author: e-mail: urashima@obihiro.ac.jp oligosaccharides . In this review, we will introduce the structural feature of human milk oligosaccharides, on their fate within the gastrointestinal tract as well as on their possible biological functions as prebiotics, anti infection agents and immunomodulation factors. In addition, we will discuss the possibility of the commercial utilization of bovine milk oligosaccharides and those of other domestic farm animals. THE CHEMICAL STRUCTURES AND THEIR QUANTITATIVE ASPECTS OF HUMAN MILK OLIGOSACCHARIDESThe structures of at least 115 human milk oligosaccharides (HMOs) have been determined to date (Urashima et al., in press), while as many as 200 diff erent oligosaccharides have been separated and studied by microfl uidic high performance liquid chromatography

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Concentrations of Sialyloligosaccharides in Bovine Colostrum and Milk during the Prepartum and Early Lactation

Cited by 135 publications

References 31 publications

Sialyl Oligosaccharides of Human Colostrum: Changes in Concentration during the First Three Days of Lactation

Sialyl Oligosaccharides of Human Colostrum: Changes in Concentration during the First Three Days of Lactation

Classification, Structure, and Bioactive Functions of Oligosaccharides in Milk

Oligosaccharides in Milk: Their Benefits and Future Utilization

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