Dengue fever has become a major public health concern. It is usually related to intravascular
leaking, bleeding disorders, and thrombocytopenia and is recognized as a potent threat to humans.
The scarcity of anti-dengue medication or vaccine for such a serious disease leads to an upsurge
in the usage of traditional medicines for its proper management. India has diverse biodiversity
and a long history of using plant-based remedies. Several medicinal plant extracts have been
studied for producing anti-dengue viral activity. AYUSH traditional systems provide a plethora of
plants that have been reported to be useful in the treatment of fever. Single and compound plant-
based formulations in natural form have been used in Unani holistic approaches. This review
serves as a new approach to illustrate the most recent evidence regarding the antiviral activity of
various plants by providing scientific proof and also to validate the traditional formulations as effective
treatments in dengue fever for global acceptance.