Concepts and correlations relevant to general anaesthesia

Urban, B. W.; Bleckwenn, Markus

doi:10.1093/bja/aef164

Cited by 85 publications

(67 citation statements)

References 35 publications

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“…isoflurane. The position of isoflurane in this schema is at odds with the relative potency as defined by MAC value, a measure determined by antinociceptive efficacy in a rigorous test model (Urban & Bleckwenn 2002). Ogawa et al (1992) studied background electrical activity in midbrain reticular cells during volatile agent anaesthesia in cats as well as reactive capability by evoked responses in the visual neuronal pathway.…”

Section: Discussionmentioning

confidence: 99%

Comparative effects of halothane, isoflurane, sevoflurane and desflurane on the electroencephalogram of the rat

2008

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SummaryInhalant anaesthetic agents are commonly used in studies investigating the electroencephalographic (EEG) effects of noxious stimuli in animals. Halothane causes less EEG depression than isoflurane, however, the EEG effects of halothane, isoflurane, sevoflurane and desflurane have not been compared in the same model. This study aimed to compare the EEG effects of these inhalational agents in the rat.Forty male Sprague-Dawley rats were assigned to four groups and anaesthetized with halothane, isoflurane, sevoflurane or desflurane. EEG was recorded from the left and right somatosensory cortices for 5 min at three different multiples of minimal alveolar concentration (MAC) (1.25, 1.5 and 1.75). Median, 95% spectral edge frequency and total power were derived and a single mean value for each was calculated for the first 60 s of each recording period. When the raw EEG contained burst suppression (BS), the BS ratio (BSR) over 60 s was calculated. No BS was found in EEG recorded from the halothane group at any concentration. BS was present at all concentrations with the other anaesthetic agents. BS was almost complete at all concentrations of isoflurane, whereas BSR increased significantly with increasing concentrations of sevoflurane and desflurane. No significant differences were found between the BSR due to the 1.75 MAC multiple of isoflurane, sevoflurane or desflurane. Halothane causes significantly less depression of cortical activity than the newer inhalant agents at equivalent multiples of MAC. These data support the hypothesis that halothane has a fundamentally different mechanism of action than the other inhalant agents.

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Section: Discussionmentioning

confidence: 99%

Comparative effects of halothane, isoflurane, sevoflurane and desflurane on the electroencephalogram of the rat

2008

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“…Ethylene, discussed in the contemporary plant sciences as stress hormone, is also a very powerful anesthetic. [10][11][12] Moreover, several anesthetics were reported to overcoming dormancy in seeds 13 and to inhibit cytoplasmic streaming. 14 Plants can react to mechanical stimuli with the use of mechano-sensitive channels but only certain plants with rapid and highly noticeable touch-stimulus response, such as Mimosa Pudica and Venus flytrap.…”

Section: Introductionmentioning

confidence: 99%

Mimosa pudica,Dionaea muscipulaand anesthetics

Luccia

2012

Plant Signaling & Behavior

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“…No general hypotheses exists [1] for the mechanism of anaesthesia. There is lack of consensus as to which physiological features constitute anaesthesia.…”

Section: Introductionmentioning

confidence: 99%

“…In 1957, Woodbridge gave four components for general anaesthesia [2]; Sensory blockade, Motor blockade, Reflex blockade of autonomic reflexes and Loss of consciousness. In 1974 Eger had two components [1]; Amnesia and Immobility. In 1987 Prys-Roberts reduced anaesthesia to one component [3]; Suppression of conscious perception of noxious stimuli.…”

Section: Introductionmentioning

confidence: 99%

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Depth of Anaesthesia: Measuring or guessing?

Landers

Wen

Pather

2010

2010 IEEE International Conference on Nano/Molecular Medicine and Engineering

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Abstract-This paper is a comprehensive literature review on the Depth of Anaesthesia (DoA) monitoring problem. We first investigate the current clinical practice, then briefly introduce the DoA monitors, finally we analyse and discuss the reliability and accuracy of current DoA assessment practice. In this study we find that most of the responses suppressed by anaestheic agents are not of the central nervous system (CNS) but are responses from the peripheral nervous systems (PNS). The responses generated for drug combinations across the therapeutic ranges show considerable variations in drug concentrations that constitute adequate anaesthesia for a particular stimulus. We propose to capture the decision process of anaesthetist using neural networks as neural networks are good at finding patterns in non linear, non stationary signals.

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Concepts and correlations relevant to general anaesthesia

Cited by 85 publications

References 35 publications

Comparative effects of halothane, isoflurane, sevoflurane and desflurane on the electroencephalogram of the rat

Comparative effects of halothane, isoflurane, sevoflurane and desflurane on the electroencephalogram of the rat

Mimosa pudica,Dionaea muscipulaand anesthetics

Depth of Anaesthesia: Measuring or guessing?

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