Concepts of Cell Lineage in Mammalian Embryos

Papaioannou, Virginia E.

doi:10.1016/bs.ctdb.2015.10.013

Cited by 7 publications

(7 citation statements)

References 23 publications

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“…Cre recombinase is also often used to dissect a cell’s developmental history, a technique known as genetic lineage tracing. 425 Here, Cre recombination is used to activate expression of a reporter gene such as LacZ or GFP in a particular tissue beginning at a selected developmental stage. Because reporter activation involves modification of the genome, it is transmitted to all of the progeny of the Cre-expressing cells.…”

Section: Functionality Of Congenital Hd Genesmentioning

confidence: 99%

Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association

Pierpont

Brueckner²,

Chung³

et al. 2018

Circulation

493

441

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This review provides an updated summary of the state of our knowledge of the genetic contributions to the pathogenesis of congenital heart disease. Since 2007, when the initial American Heart Association scientifi statement on the genetic basis of congenital heart disease was published, new genomic techniques have become widely available that have dramatically changed our understanding of the causes of congenital heart disease and, clinically, have allowed more accurate definition of the pathogeneses of congenital heart disease in patients of all ages and even prenatally. Information is presented on new molecular testing techniques and their application to congenital heart disease, both isolated and associated with other congenital anomalies or syndromes. Recent advances in the understanding of copy number variants, syndromes, RASopathies, and heterotaxy/ciliopathies are provided. Insights into new research with congenital heart disease models, including genetically manipulated animals such as mice, chicks, and zebrafish as well as human induced pluripotent stem cell–based approaches are provided to allow an understanding of how future research breakthroughs for congenital heart disease are likely to happen. It is anticipated that this review will provide a large range of health care–related personnel, including pediatric cardiologists, pediatricians, adult cardiologists, thoracic surgeons, obstetricians, geneticists, genetic counselors, and other related clinicians, timely information on the genetic aspects of congenital heart disease. The objective is to provide a comprehensive basis for interdisciplinary care for those with congenital heart disease.

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Section: Functionality Of Congenital Hd Genesmentioning

confidence: 99%

Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association

Pierpont

Brueckner²,

Chung³

et al. 2018

Circulation

493

441

View full text Add to dashboard Cite

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“…Cell lineage, which denotes the developmental history of a cell, provides the conceptual framework for understanding organism formation (Papaioannou, 2016; Stent, 1985). For example, identifying the lineage relationship among neurons is essential for understanding how neurons gain specific physiological, morphological, and neurochemical features and proper circuit connectivity (Hobert and Kratsios, 2019; Lacin et al, 2019; Lee, 2017).…”

Section: Introductionmentioning

confidence: 99%

Identification of Neuronal Lineages in the Drosophila Peripheral Nervous System with a “Digital” Multi-spectral Lineage Tracing System

Veling

et al. 2019

Cell Reports

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SUMMARY Elucidating cell lineages provides crucial understanding of development. Recently developed sequencing-based techniques enhance the scale of lineage tracing but eliminate the spatial information offered by conventional approaches. Multi-spectral labeling techniques, such as Brainbow, have the potential to identify lineage-related cells in situ. Here, we report nuclear Bitbow (nBitbow), a “digital” version of Brainbow that greatly expands the color diversity for scoring cells, and a suite of statistical methods for quantifying the lineage relationship of any two cells. Applying these tools to the Drosophila peripheral nervous system (PNS), we determined lineage relationship between all neuronal pairs. This study demonstrates nBitbow as an efficient tool for in situ lineage mapping, and the complete lineage relationship among larval PNS neurons opens new possibilities for studying how neurons gain specific features and circuit connectivity.

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“…were widely applied in retrovirus-based and genetic-based population lineage tracing. 18 , 19 , 20 , 21 The implementation of two recombinase systems (Cre-loxP and FLP-FRT) further enhanced the effectiveness of using fluorescent reporter genes in lineage tracing to achieve cell-type-specific or tissue-specific labeling. 22 , 23 , 24 The combination of multicolor reporter genes with recombinase systems in genetic animal models, such as Brainbow and Confetti mice, then permitted for clonal tracing of fluorescent cells in vivo and ex vivo , 25 , 26 whereas continuous observation of color-coded clones by time-lapse imaging served to inform on dynamic changes of clones arising from a single stem cell.…”

Section: History and Development Of Clonal Analysismentioning

confidence: 99%

“…Subsequently, GFP and its derivatives (YFP, RFP, CFP, etc.) were widely applied in retrovirus-based and genetic-based population lineage tracing 18, 19, 20, 21. The implementation of two recombinase systems (Cre-loxP and FLP-FRT) further enhanced the effectiveness of using fluorescent reporter genes in lineage tracing to achieve cell-type-specific or tissue-specific labeling 22, 23, 24.…”

Section: History and Development Of Clonal Analysismentioning

confidence: 99%

Illumination of neural development by in vivo clonal analysis

Wang

Guo

et al. 2018

Cell Regeneration

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Single embryonic and adult neural stem cells (NSCs) are characterized by their self-renewal and differentiation potential. Lineage tracing via clonal analysis allows for specific labeling of a single NSC and tracking of its progeny throughout development. Over the past five decades, a plethora of clonal analysis methods have been developed in tandem with integration of chemical, genetic, imaging and sequencing techniques. Applications of these approaches have gained diverse insights into the heterogeneous behavior of NSCs, lineage relationships between cells, molecular regulation of fate specification and ontogeny of complex neural tissues. In this review, we summarize the history and methods of clonal analysis as well as highlight key findings revealed by single-cell lineage tracking of stem cells in developing and adult brains across different animal models.

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Concepts of Cell Lineage in Mammalian Embryos

Cited by 7 publications

References 23 publications

Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association

Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association

Identification of Neuronal Lineages in the Drosophila Peripheral Nervous System with a “Digital” Multi-spectral Lineage Tracing System

Illumination of neural development by in vivo clonal analysis

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