Conceptual combination of disinfection in regenerative endodontics: Conventional versus laser-assisted disinfection

Divya, D; Naik, SaraswathiV; Raju, O S; Bellal, Shivani; Basappa, N; Betur, ArchanaP

doi:10.4103/jcd.jcd_96_21

Cited by 11 publications

(8 citation statements)

References 36 publications

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“…With respect to disinfection, maintaining a sterile working environment is crucial for all endodontic procedures, including regenerative therapy 31,32 . Nonetheless, regenerative treatments rely on living cells and natural physiological processes, so eliminating bacteria and ensuring the survival of endogenous cells can be complex undertakings, especially when using a bleeding technique.…”

Section: Discussionmentioning

confidence: 99%

Orthodontic Movement After Regenerative Endodontic Procedure in Mature Permanent Tooth Associated With Dens Invaginatus: A Case Report With 3-year Follow-Up

Martínez,

Oyonarte,

Concha

et al. 2024

Preprint

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Background Regenerative endodontic procedures (REPs) are innovative treatments aimed at restoring damaged dental structures. However, the effect of orthodontic movement on REP-treated teeth is not well understood and may have significant long-term consequences. This study aimed to evaluate the impact of orthodontic movement on a mature permanent tooth associated with dens invaginatus that has undergone a regenerative endodontic procedure (REP). Case presentation: This case involves a preliminary investigation into the effects of orthodontic movements on a mature REP-treated tooth. This could have the potential to enrich our collective understanding and guide treatment planning, leading to the development of clinical guidelines. This report describes the case of a 13-year-old male with a noncontributory medical history who presented with pulp necrosis and a chronic apical abscess (tooth number 2.2). Following REP according to the American Association of Endodontists' guidelines, the patient began orthodontic treatment after 9 months. Subsequent follow-ups at 9 months, 2 years, and 3 years post-REP revealed an asymptomatic state with minimal cervical discolouration and diminished cold sensitivity. Radiographic analyses revealed periapical healing, dentin wall thickening, and consistent root length. The treated tooth displayed a positive response to both REP and orthodontic treatment, yet further research is necessary to determine the long-term effects of orthodontic forces on REP-treated teeth. Conclusion Our findings suggest that orthodontic movement following REPs in mature permanent teeth is feasible and may also act as a protective factor against apical root resorption. Our experience indicates that a 9-month healing period permits successful orthodontic outcomes following REPs. Nonetheless, the predictability of outcomes and the ideal healing period before orthodontic movement is initiated remain to be established.

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Section: Discussionmentioning

confidence: 99%

Orthodontic Movement After Regenerative Endodontic Procedure in Mature Permanent Tooth Associated With Dens Invaginatus: A Case Report With 3-year Follow-Up

Martínez,

Oyonarte,

Concha

et al. 2024

Preprint

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“…[ 85 ] It has also been demonstrated that including the diode laser in the AAE regenerative guidelines improved disinfection and periapical healing. [ 88 ] On this basis, irrigant activation through different methods could be widely investigated to perform pulp regeneration. In the present study, irrigant activation was mentioned on four teeth in total, which in particular employed a photoactivated activation with a diode laser on two teeth and an ultrasonic activation on two teeth as well.…”

Section: Discussionmentioning

confidence: 99%

Pulp regeneration treatment using different bioactive materials in permanent teeth of pediatric subjects

Abdellatif,

Iandolo,

De Benedetto

et al. 2024

Journal of Conservative Dentistry and Endodontics

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Background and Objectives: The present systematic review aims to assess the success rate of the pulp regeneration treatment, according to the American Association of Endodontists (AAE) criteria, using different bioactive materials in permanent teeth of pediatric subjects (6–17 years of age). Materials and Methods: The study protocol was registered on PROSPERO and adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. The question formulation was accomplished using the PICO model, and an electronic search was carried out on Scopus, MEDLINE/PubMed, Web of Science, and Cochrane databases till April 1, 2023. A total of 30 studies were established to fulfill the inclusion criteria of this systematic review. Results: A total of 273 teeth have been treated with pulp regeneration treatment. By comparing different biomaterials and the success criteria defined by the AAE, the material associated with a higher success rate was found to be the white mineral trioxide aggregate. However, the overall success rate of pulp regeneration treatment was reported for 248 out of 273 teeth (91.20%). Conclusions: Data obtained support the potential that regenerative endodontics aids in continuing root development in permanent immature teeth. Further studies are needed for a more extensive evaluation of the use of different biomaterials and the success rate in regenerative endodontics.

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“…CO 2 laser bursts effectively removed bacteria inoculated on pig skin in an experiment. A sterile environment is a prerequisite of regenerative endodontic treatment, which could be effectively achieved with the assistance of a CO 2 laser ( Mullarky et al, 1985 ; Nammour and Majerus, 1991 ; Divya et al, 2021 ). Low-level laser with 660 nm wavelength and 100 mW power has been used for sterilization of the decellularized lung tissues ( Lopes Guimarães et al, 2020 ).…”

Section: Sterilizationmentioning

confidence: 99%

“…Low-level laser with 660 nm wavelength and 100 mW power has been used for sterilization of the decellularized lung tissues ( Lopes Guimarães et al, 2020 ). Laser is an appropriate option for effectively disinfecting tissues, and its potential for disinfecting the dECM should be further explored ( Mullarky et al, 1985 ; Nammour and Majerus, 1991 ; Divya et al, 2021 ).…”

Section: Sterilizationmentioning

confidence: 99%

Decellularization in Tissue Engineering and Regenerative Medicine: Evaluation, Modification, and Application Methods

Neishabouri

Khaboushan

Daghigh

et al. 2022

Front. Bioeng. Biotechnol.

114

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Reproduction of different tissues using scaffolds and materials is a major element in regenerative medicine. The regeneration of whole organs with decellularized extracellular matrix (dECM) has remained a goal despite the use of these materials for different purposes. Recently, decellularization techniques have been widely used in producing scaffolds that are appropriate for regenerating damaged organs and may be able to overcome the shortage of donor organs. Decellularized ECM offers several advantages over synthetic compounds, including the preserved natural microenvironment features. Different decellularization methods have been developed, each of which is appropriate for removing cells from specific tissues under certain conditions. A variety of methods have been advanced for evaluating the decellularization process in terms of cell removal efficiency, tissue ultrastructure preservation, toxicity, biocompatibility, biodegradability, and mechanical resistance in order to enhance the efficacy of decellularization methods. Modification techniques improve the characteristics of decellularized scaffolds, making them available for the regeneration of damaged tissues. Moreover, modification of scaffolds makes them appropriate options for drug delivery, disease modeling, and improving stem cells growth and proliferation. However, considering different challenges in the way of decellularization methods and application of decellularized scaffolds, this field is constantly developing and progressively moving forward. This review has outlined recent decellularization and sterilization strategies, evaluation tests for efficient decellularization, materials processing, application, and challenges and future outlooks of decellularization in regenerative medicine and tissue engineering.

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Conceptual combination of disinfection in regenerative endodontics: Conventional versus laser-assisted disinfection

Cited by 11 publications

References 36 publications

Orthodontic Movement After Regenerative Endodontic Procedure in Mature Permanent Tooth Associated With Dens Invaginatus: A Case Report With 3-year Follow-Up

Orthodontic Movement After Regenerative Endodontic Procedure in Mature Permanent Tooth Associated With Dens Invaginatus: A Case Report With 3-year Follow-Up

Pulp regeneration treatment using different bioactive materials in permanent teeth of pediatric subjects

Decellularization in Tissue Engineering and Regenerative Medicine: Evaluation, Modification, and Application Methods

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