The deflection magnet (DM) is the most important component of the Neutral Beam Injection (NBI) system of Experimental Advanced Superconducting Tokamak (EAST), which can magnetically deflect the un-neutralized charged particles after the neutralized process of the beam is extracted from the ion source, and then form a neutral beam injected into the tokamak. Under the operating conditions of the NBI system, by using the thermocouple monitoring system in the experiment, it can be found that the currently operating DM beam collimator has a quite high temperature rise. It is necessary to redesign the DM beam collimator to improve its heat transfer performance. The parallel arrangement of multiple rows of tubes is proposed as the basic method for the redesign of the beam collimator of DM, the thermal-fluid-structure analysis model of this redesign model is established and its temperature field, pressure field and stress field are analyzed. Taking the surface temperature of the beam collimator, the overall dimension after the total tube combination and the pressure drop of the whole structure of collimator as the optimization objectives, and setting the fluid velocity, the tube’s inner diameter and the number of tube rows as the design variables, the optimized design scheme of the beam collimator structure is obtained. From the results of simulation, the new structure can better meet the operation requirements of DM, and its maximum temperature rise is well controlled, which is expected to meet the long pulse operation requirements of the NBI system. The proposed simulation and design optimization method can provide a certain reference for the design and optimization of other high-heat-flux structures in complex large-scale neutral beam systems in the future.