Concise Book of Medical Laboratory Technology: Methods and Interpretations

Sood, Ramnik

doi:10.5005/jp/books/10169

Cited by 33 publications

(41 citation statements)

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“…The low dose treatment animals show a negligible weight loss while the high dose treatment animals showed an appreciable loss in weight. [11]; [12] did a similar work on antimalarial drugs containing fixed combination of Pyrimethamine and Sulfadoxine but he checked on haematological parameters. While the drugs administered caused elevation in hematological indices resulting in hemoglobinuria, polycythemia, leukocytosis, neutrophilia and lymphocytosis, which further confirms the result from the present study on visceral organs of the same albino rats used as models.…”

Section: Discussionmentioning

confidence: 99%

“…Crenated blood cells observed in CS and CP administered groups showed destructive property of the drugs on red blood cells. According to [12] Crenation is the contraction of a cell after exposure to a hypertonic solution due to the loss of water through osmosis. The effects of crenation is visible in red blood cells, or erythrocytes, as they become distorted in shape rather than maintaining the usual disc-like shape with dimple that the blood cell normally has instead.…”

Section: Discussionmentioning

confidence: 99%

“…According to him the findings indicates that LOR may exert the same effects as tenoxicam on liver and kidney lysosomal membranes while [8] observed similar alterations but in lysosomal enzymes which they claim may contribute to explain the hepatotoxicity and nephrotoxicity under the effects of some NSAIDS drugs (in which Sulfonamide is an active ingredient) and inturn it leads to the labialization of the lysosomal membrane and further leads to the leakage of lysosomal enzymes [9]; [10] . Moreso, [11]; [12] worked on antimalarial drugs containing fixed combination of Pyrimethamine and Sulfadoxine but was centered on haematological parameters. According to them, the drugs administered caused elevation in hematological indices resulting in hemoglobinuria, polycythemia, leukocytosis, neutrophilia and lymphocytosis.…”

Section: Introductionmentioning

confidence: 99%

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Histological effects of pre-exposure prophylactic consumption of sulfa drugs on Liver and Kidney of albino Wister rats (Rattus novergicus).

Odigie¹

2013

IOSR-JPBS

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Histological effects of pre-exposure prophylactic consumption of sulfa drugs on Liver and Kidney of albino Wister rats (Rattus novergicus).

Odigie¹

2013

IOSR-JPBS

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“…Section of the liver was perfused with cold 0.86% KCl, homogenised, and centrifuged to obtain post mitochondrial supernatant for estimation of liver reduced glutathione and malondialdehyde content. The activities of serum transaminases (ALT and AST), alkaline phosphatase, albumin, total protein, bilirubin (total and direct), total cholesterol, triglycerides and high density lipoprotein were assayed by Randox (assay kit) methods of Reitman and Frankel (1957), Sood (1999), Doumas et al (1971), Gornall et al (1949), Jendrassik and Grof (1938), Trinder (1969), Tietz (1990), andLopez-Virella et al (1977) respectively. Serum levels of low density lipoprotein and very low density lipoprotein were calculated by using Friedewald formula (Friedewald et al, 1972).…”

Section: Clinical Chemistrymentioning

confidence: 99%

Hepatoprotective Effect of the Aqueous Leaf Extract of Andrographis paniculata Nees Against Carbon Tetrachloride – Induced Hepatotoxicity in Rats

Nasir¹,

Abubakar²,

Shehu³

et al. 2013

Nig J Bas App Sci

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Hepatoprotective effect of the aqueous leaf extract of Andrographis paniculata was investigated against CCl4 -induced hepatic injury in rats. Significant (P<0.05) increase of serum levels of alanine aminotransferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), total bilirubin (TBL), direct bilirubin (DBL), total cholesterol (CHL), triglycerides (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and malondialdehyde (MDA) in CCl4 intoxicated rats were restored to normal levels when treated with the extract and CCl4. Significant (P<0.05) decrease of serum levels of total protein (TP), albumin (ALB), high density lipoprotein (HDL) and reduced glutathione (GSH) in CCl4 intoxicated rats were restored to normal levels when treated with the extract and CCl4. The LD50 of the leaf extract was greater than 3000 mg/kg. The study demonstrated that A. paniculata possesses significant hepatoprotective effects and may be the source of lead compound in the management of liver diseases.

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“…Dip-stick test reactions using urine reagent strips (Uro dip 10 A -ERBA diagnostics, Germany) were observed and recorded. Motion test, chest X ray, ECG and Echocardiogram were also done [13][14][15][16][17][22][23][24] .…”

Section: Evaluation Of Clinical Parametersmentioning

confidence: 99%

A Study on Siddha Urinary Diagnostic Methodology Neerkkuri and Neikkuri in Adhiratha Azhutham (Hypertension)

Banu¹,

Parvathy²,

Srinivasan³

et al. 2017

IJPCS

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Background:In Siddha system of medicine, diagnosis of the disease is based on Ennvagai thervukal (Eight fold examination), in which Neerkkuri Neikkuri (Urine examination) is one among them. It is an effective and sensitive measure for the diagnosis and prognosis of diseases. Objectives: This study was conducted to establish the validity of prognostic and diagnostic patterns of Neikkuri (Oil on urine sign)in hypertension patients and to assess the association between the Neikkuri patterns with respect to pH and specific gravity of urine. Methods and Material: Urine samples of 40 diagnosed patients of hypertension aged between 30 to 60 years were collected. Ten healthy volunteers were also selected as control group for comparison. Biochemical analysis was done in the urine samples with urine reagent strip to confirm health status of the subjects. A drop of sesame oil was dropped over 50 ml of each urine sample and behaviour (shape of the oil spread, direction and spread time) was observed. Results: Half of the samples of urine of hypertension patients showed circular shape initially and then vacuolating to turn out into a sieve pattern and in remaining others at least a single vacuolation amounting to ring pattern indicative of Pitham were shown. Also, the urine of the hypertension patients were characterised by straw colour and aromatic odour, absence of froth and specific gravity 1.003-1.010.Volume of urine voided ranged from 1-1.5 lit and pH between 5.1-6.In most of the cases the dissemination dynamics of oil drop observed were of slow spreading nature which indicates good prognosis. Conclusion: It is concluded that hypertension has got mixed prognosis which may indicate the variation in the amenability of hypertension to the treatment. The study explored the veracity of the investigative procedure in diagnosis and prognosis of hypertension with Neikkuri examination.

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Concise Book of Medical Laboratory Technology: Methods and Interpretations

Cited by 33 publications

References 0 publications

Histological effects of pre-exposure prophylactic consumption of sulfa drugs on Liver and Kidney of albino Wister rats (Rattus novergicus).

Histological effects of pre-exposure prophylactic consumption of sulfa drugs on Liver and Kidney of albino Wister rats (Rattus novergicus).

Hepatoprotective Effect of the Aqueous Leaf Extract of Andrographis paniculata Nees Against Carbon Tetrachloride – Induced Hepatotoxicity in Rats

A Study on Siddha Urinary Diagnostic Methodology Neerkkuri and Neikkuri in Adhiratha Azhutham (Hypertension)

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