Concise Review: Cell Therapy and Tissue Engineering for Cardiovascular Disease

Abstract

Cardiovascular disease is a major cause of morbidity and mortality, especially in developed countries. Various therapies for cardiovascular disease are investigated actively and are performed clinically. Recently, cell-based regenerative medicine using several cell sources has appeared as an alternative therapy for curing cardiovascular diseases. Scaffold-based or cell sheet-based tissue engineering is focused as a new generational cell-based regenerative therapy, and the clinical trials have also been started. Cell-based regenerative therapies have an enormous potential for treating cardiovascular disease. This review summarizes the recent research of cell sources and cell-based-regenerative therapies for cardiovascular diseases.

Influence of viscoelastic properties of an hyaluronic acid-based hydrogel on viability of mesenchymal stem cells

“…One of the greatest challenges of the regenerative medicine is to enable the repair of injured native tissue using cellular therapies particularly by combining stem cells with biomaterials scaffolds [1,2].…”

MicroRNA-155 in the Heart

“…1 Accordingly, there has been a tremendous interest in using novel therapies to revascularize ischemic tissue and to repair damaged myocardium after MI. 2 Although there is a clear clinical need to promote collateral vessel growth to facilitate healing and to preserve tissue integrity after an ischemic event, the mechanisms that govern the growth of collateral vessels remain largely unknown. In this issue of Circulation, Pankratz and colleagues 3 use microRNAs (miRNAs) to study the different mechanisms that promote angiogenesis and arteriogenesis and find that microRNA-155 (miR-155) has dual and opposing roles in both processes.…”

Development of a thin-film porous-microelectrode array (p-mea) for electrical stimulation of engineered cardiac tissue.

“…However, these voltages far exceed the water electrolysis threshold voltage of 1.23V [13] and can produce gas bubbles in the culture medium which may impede nutrient stability, delivery, and cause cell injury. Another confounding variable is the high-glucose content of standard ECT culture media.…”

“…The second approach is the focus of cardiac tissue engineering. Interest in tissue engineering by numerous research groups in the past decade or so has generated a wealth of knowledge about the field [6,7,12,13,15,21,37,39,[41][42][43][44][45][46][47][48].…”