Concomitant and productive genital infections by HSV-2 and HPV in two young women: A case report

Uysal, Ilkay Başak; Boué, Vanina; Murall, Carmen Lía; Graf, Christelle; Selinger, Christian; Hirtz, Christophe; Bernat, Claire; Ravel, Jacques; Reynes, Jacques; Bonneau, Marine; Rahmoun, Massilva; Segondy, Michel; Boulle, Nathalie; Grasset, Sophie; Groc, Soraya; Waterboer, Tim; Tribout, Vincent; Bravo, Ignacio G.; Burrel, Sonia; Foulongne, Vincent; Alizon, Samuel; Tessandier, Nicolas

doi:10.1016/j.idcr.2022.e01604

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…33,34 Genital infection caused by HSV and HPV coinfections are increasingly being reported, as the lytic virus HSV-2 has the ability to modulate the barrier providing cervical mucus, leading to heightened inflammatory immune responses. 15,35 The viral interaction with vaginal microbiota suggests its role in aiding coexistence. 36 Additionally, coinfections that support HPV fusion are reported to be caused by EBV, which helps in initiating epithelial-mesenchymal transition (EMT) and consequently promoting tumour proliferation.…”

Section: Viral Coinfectionsmentioning

confidence: 99%

“…Genital infection caused by HSV and HPV coinfections are increasingly being reported, as the lytic virus HSV‐2 has the ability to modulate the barrier providing cervical mucus, leading to heightened inflammatory immune responses 15,35 . The viral interaction with vaginal microbiota suggests its role in aiding co‐existence 36 .…”

Section: Microbial Coinfections In Hpv‐associated Cancers: An Epidemi...mentioning

confidence: 99%

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Coinfections in human papillomavirus associated cancers and prophylactic recommendations

Ashok,

Basu,

Priyamvada

et al. 2024

Reviews in Medical Virology

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The Human Papillomavirus (HPV) infection is responsible for more than 80% of reported cervical cancer and other virus‐associated tumours. Although this global threat can be controlled using effective vaccination strategies, a growing perturbation of HPV infection is an emerging coinfection likely to increase the severity of the infection in humans. Moreover, these coinfections prolong the HPV infections, thereby risking the chances for oncogenic progression. The present review consolidated the clinically significant microbial coinfections/co‐presence associated with HPV and their underlying molecular mechanisms. We discussed the gaps and concerns associated with demography, present vaccination strategies, and other prophylactic limitations. We concluded our review by highlighting the potential clinical as well as emerging computational intervention measures to kerb down HPV‐associated severities.

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Section: Viral Coinfectionsmentioning

confidence: 99%

Section: Microbial Coinfections In Hpv‐associated Cancers: An Epidemi...mentioning

confidence: 99%

Coinfections in human papillomavirus associated cancers and prophylactic recommendations

Ashok,

Basu,

Priyamvada

et al. 2024

Reviews in Medical Virology

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“…We implemented a uniplex version of the HPV genotype-specific method from Micalessi et al (2012) and further described in Uysal et al (2022).…”

Section: Qpcrmentioning

confidence: 99%

Factors associated with human papillomavirus (HPV) virus load variations in genital infections in young women

Tessandier,

Boué,

Kamyia

et al. 2024

Preprint

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Human papillomaviruses (HPVs) are the most oncogenic viruses known to humans, with 12 high-risk (HR) genotypes causing nearly all cervical cancers. Cytology is commonly used to screen for cervical lesions but is currently being replaced by testing for high-risk HPV (HR HPV). Although HR HPV screening has a higher sensitivity, its specificity is limited, and it is currently advised to repeat the first screening 4 to 6 months later. To increase the sensitivity of the screening triage, other biomarkers have been suggested, including HPV viral load. Indeed, since 1999, several independent studies have found an association between HR HPV viral load in cervical samples and the severity of cervical disease. Here, we further explore the determinants of variations in HPV viral load in genital infections in young adult women.We analysed samples collected in the PAPCLEAR clinical cohort for participants who were infected by HPV genotypes for which we quantified virus load using qPCR targeting 13 genotypes. We developed a Bayesian statistical model estimating the effect of covariates of interest on the HPV viral load. To analyse precisely the viral load difference between HPV genotypes, phylogenetic distances between HPVs were also integrated in the Bayesian model.Our results fail to identify an effect of anti-HPV vaccination, co-infections by multiple HPVs or tobacco smoking on the detected viral load. On the opposite, swabs contained significantly more viral copies than cervical smears. Our results also highlight that most of the viral load variance could be explained at the genotype level (80%) rather than at the individual level (20%). Our model reveals important differences in viral load detected between the different genotypes tested, with HPV16 being the highest and HPV18 the lowest. The impact of phylogenetic signal on viral load was also estimated to be low, except for a cluster comprised of HPV53, HPV66 and HPV56. These results contribute to identifying the main drivers of HPV viral load detected and could help design needed future screening policies.

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“…In high-risk HPV (hr-HPV) infection, e.g, UCHL1 de-ubiquitinates TRAF3 and NEMO (adaptor proteins of TLRs and RLRs pathway), impairing cytokines and IFN-I production (11). These genes and cytokines are differentially expressed when comparing cervical cells from HPV-infected (HPV+) and uninfected (HPV-) women and may have important roles in HPV persistence or clearance and in susceptibility to STIs such as HIV infection (12)(13)(14)(15). Furthermore, several studies suggest important roles of PRR expression and host microbiota in health and disease at mucosal sites (16)(17)(18), but little is known about the FRT.…”

Section: Introductionmentioning

confidence: 99%

Microbiome analysis of Brazilian women cervix reveals specific bacterial abundance correlation to RIG-like receptor gene expression

et al. 2023

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The relationship among microbiome, immunity and cervical cancer has been targeted by several studies, yet many questions remain unanswered. We characterized herein the virome and bacteriome from cervical samples and correlated these findings with innate immunity gene expression in a Brazilian convenience sample of HPV-infected (HPV+) and uninfected (HPV-) women. For this purpose, innate immune gene expression data were correlated to metagenomic information. Correlation analysis showed that interferon (IFN) is able to differentially modulate pattern recognition receptors (PRRs) expression based on HPV status. Virome analysis indicated that HPV infection correlates to the presence of Anellovirus (AV) and seven complete HPV genomes were assembled. Bacteriome results unveiled that vaginal community state types (CST) distribution was independent of HPV or AV status, although bacterial phyla distribution differed between groups. Furthermore, TLR3 and IFNαR2 levels were higher in the Lactobacillus no iners-dominated mucosa and we detected correlations among RIG-like receptors (RLR) associated genes and abundance of specific anaerobic bacteria. Collectively, our data show an intriguing connection between HPV and AV infections that could foster cervical cancer development. Besides that, TLR3 and IFNαR2 seem to create a protective milieu in healthy cervical mucosa (L. no iners-dominated), and RLRs, known to recognize viral RNA, were correlated to anaerobic bacteria suggesting that they might be related to dysbiosis.

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Concomitant and productive genital infections by HSV-2 and HPV in two young women: A case report

Cited by 4 publications

References 18 publications

Coinfections in human papillomavirus associated cancers and prophylactic recommendations

Coinfections in human papillomavirus associated cancers and prophylactic recommendations

Factors associated with human papillomavirus (HPV) virus load variations in genital infections in young women

Microbiome analysis of Brazilian women cervix reveals specific bacterial abundance correlation to RIG-like receptor gene expression

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