Concomitant poroma and porocarcinoma

Abarzúa, Álvaro; Álvarez-Véliz, Sergio; Moll-Manzur, Catherina

doi:10.1590/abd1806-4841.20175719

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…The exact etiology of EPC is unclear. Some authors suggested a possible association with radiation exposure and immunosuppression, although an excessive sun exposure does not seem to be a significant risk factor [17-19].…”

Section: Discussionmentioning

confidence: 99%

Intergluteal Cleft Eccrine Porocarcinoma with Metastasis to Inguinal Region and Lung: Case Report and Review of the Literature

Fernández-Ferreira¹,

Alvarado-Luna²,

Motola-Kuba³

et al. 2020

Case Rep Oncol

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Eccrine porocarcinoma (EPC) is an infrequent cutaneous neoplasm, and was described in 1963 by Pinkus and Mehregan. It is a rare type of skin tumor (0.005–0.01% of all skin tumors). Less than 300 cases have been described in the entire world medical literature. To our knowledge, no case of intergluteal cleft EPC has been reported in the literature in English and Spanish to date, so this would be the first reported case of such pathology. Metastatic EPC is less frequent, since only <10% of metastatic type have been reported and the rest as localized disease. The primary treatment of choice is surgical wide local excision of the tumor with histological confirmation of tumor-free margins. Prognosis is difficult to determine because of the rarity of EPC and the variations in natural history. There are no data to support the use of adjuvant chemotherapy or radiotherapy, and there are currently no agreed criteria to define patients at high risk of relapse. We present a 67-year-old man with intergluteal cleft eccrine tumor by biopsy. Metastasis to left inguinal region and lung was reported by contrasted abdominal and chest computed tomography. He started chemotherapy based on etoposide, vincristine, carboplatin. A review of pertinent literature is provided.

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Section: Discussionmentioning

confidence: 99%

Intergluteal Cleft Eccrine Porocarcinoma with Metastasis to Inguinal Region and Lung: Case Report and Review of the Literature

Fernández-Ferreira¹,

Alvarado-Luna²,

Motola-Kuba³

et al. 2020

Case Rep Oncol

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“…Debido a un amplio diagnóstico diferencial, e inclusive casos mal diagnosticados como carcinomas epiteliales de piel (4) , la biopsia es fundamental para un diagnóstico correcto de estos tumores de anexos de piel. La evaluación histopatológica muestra células tumorales atípicas con patrón de crecimiento infiltrativo, formación de estructuras lobulares, reacción desmoplásica del estroma, núcleos pleomórficos, invasión vascular y perineural (11) ; existen casos reportados de coexistencia de poroma con porocarcinoma, los cuales sugieren que derivan de estas lesiones benignas (12) . Asimismo, existen factores pronósticos de recidivas como el patrón histológico infiltrativo, profundidad del tumor > 7mm, > 14 mitosis x campo de alta potencia, invasión linfática, vascular y perineural, según los criterios de Robson (5) .…”

Section: Discussionunclassified

Porocarcinoma ecrino metastásico

Calsina

Coras

2019

An Fac med

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Presentamos el caso de un paciente varón de 69 años, con lesión tumoral en región inguinal izquierda, asintomática. El estudio histopatológico e inmunohistoquímico fue consistente con porocarcinoma ecrino. A la realización de imágenes se evidenció metástasis ganglionares en región iliaca femoral, retroperitoneal y supraclavicular izquierda. Se confirmó infiltración de porocarcinoma ecrino en ganglio supraclavicular al estudio histopatológico. El porocarcinoma ecrino metastásico es de muy rara presentación. El tratamiento quirúrgico no es posible en estos casos. No existe un tratamiento estándar sistémico, solo series de casos con respuestas variables. Nuestro paciente recibió tratamiento sistémico con docetaxel con buena tolerancia.

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“…Elderly patients are the most affected, with a peak incidence between the 6 th and7th decade of life. Although it does not seem to have a predilection for sex or race, some studies indicate a slight prevalence in women [ 7 , 9 ]. The exact etiology of EPC is unclear.…”

Section: Discussionmentioning

confidence: 99%

“…This elevate incidence of local recurrence may be due to a not optimal free margin at surgical excision. Lymph node metastases are present at diagnosis in 20% of cases and the incidence of visceral metastases is reported to be 10% [ 8 , 9 ]. The tumor tends to spread tangentially in the lower third of the epidermis, then after infiltrates the dermis, subcuticular fat and lymphatic system.…”

Section: Discussionmentioning

confidence: 99%