Concordance between the tuberculin skin test and interferon gamma release assays for diagnosing latent tuberculosis infection in patients with chronic inflammatory arthritis

Nazlıgül, Tuba

doi:10.14744/bmj.2021.93823

Cited by 2 publications

(3 citation statements)

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“…Nazlıgül. et al also found that IGST was a better method than TST as a latent TB screening method in 47 patients with chronic inflammatory arthritis [17]. In addition, in our clinical practice, IGST was used for latent TB screening before biological agent treatment in accordance with the literature.…”

Section: Discussionmentioning

confidence: 62%

Reasons for requesting an interferon gamma release test from internal medicine and rheumatology clinics and evaluation of the results

2023

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Background/Aim: Tuberculosis is a disease involving many systems, such as the lung, gastrointestinal system, genitourinary system, etc. Detecting this disease in its latency significantly reduces the morbidity and mortality associated with tuberculosis. One of the tests used in latent TB screening is the interferon gamma release test. In rheumatology practices, it is routinely used to screen for latent tuberculosis infections before treatment with biological agents and Janus kinase (JAK) inhibitors, and it can also be used to exclude tuberculosis infection in clinical practice. In our study, we aimed to evaluate the reasons for requesting interferon gamma release tests and the results of this test in patients who requested it. Methods: Patients admitted to internal medicine and rheumatology outpatient clinics were retrospectively screened within the retrospective cohort study. In total, 364 patients who requested interferon gamma release testing were included in the study. Nine patients with unclear test results were excluded. Laboratory results, demographic data, reasons for requesting the interferon gamma release test, and results were evaluated. Results: The interferon gamma release test was requested by 355 patients. Of these, 266 patients (74.9%) asked for latent tuberculosis screening before treatment with biological agents and JAK inhibitors. This was followed by patients with peripheral lymphadenopathy-lung nodules, patients with unexplained elevated acute phase reactants, and patients with constitutional symptoms, respectively. Ten out of 107 patients (9.3%) had an active tuberculosis infection, while six out of ten patients (60%) had pulmonary tuberculosis, and four (40%) had extrapulmonary tuberculosis. Conclusion: The most common reason for requesting the interferon gamma release test in internal medicine and rheumatology clinics was screening for latent tuberculosis before treatment with biologic agents and JAK inhibitors. In internal medicine, it has been observed that this test can also be requested by patients with constitutional symptoms, unexplained elevated acute phase reactants, and a preliminary diagnosis of tuberculosis in order to rule out or strengthen the preliminary diagnosis.

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Section: Discussionmentioning

confidence: 62%

Reasons for requesting an interferon gamma release test from internal medicine and rheumatology clinics and evaluation of the results

2023

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“…The discrepancy was observed in a quarter of the results with a high trend in the TST (QFT−/TST+), this could be explained by the false-positive results which are common in TST due to cross-reaction with the BCG vaccine or environmental non-tuberculous mycobacteria [11].…”

Section: Appropriate Cut-off Points From Tst In Accord With High Agre...mentioning

confidence: 93%

“…The TST measures the delayed-type hypersensitivity response to intradermal injection of a mixture of purified protein that derivatives from many mycobacterial antigens, including M. tuberculosis, M. bovis BCG, and non-tuberculous mycobacteria (NTM) [9]. However, this test is characterized by a high rate of false positive in high TB burden settings and in immunocompromised subjects [10] [11] [12]. Furthermore, this test requires a second visit within 48 hours to 72 hours for result reading and interpretation [13].…”

Section: Introductionmentioning

confidence: 99%

What Tool for Diagnosis of Latent Tuberculosis Infection in Developing Country with Tuberculosis High Burden: Interferon Gamma Release Assays <i>versus</i> Tuberculin Skin Test in Burkina Faso

Djibougou¹,

Mensah²,

Kientega³

et al. 2022

AID

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Background: The diagnosis and treatment of active tuberculosis and the detection/management of latent tuberculosis infection (LTBI) cases are the two main strategies for the TB control, particularly in endemic countries. Tuberculin skin test (TST) and Interferon Gamma Release Assays (IGRAs) are tools for detection of LTBI. The objective of this study was to evaluate the performance of the TST and QuantiFERON-TB Gold Plus ® (QTF-Plus) and to identify a threshold for TST in best agreement with QTF-Plus for LTBI detection in a high TB burden setting. Methods: In July 2020, a cross-sectional analytical study was performed for QFT-Plus using blood samples and TST in 101 individuals with a high risk of TB living in Bobo-Dioulasso, Burkina Faso. A crude comparison between both tests was done and receiver operating characteristic curve was generated to determine TST's threshold.

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Concordance between the tuberculin skin test and interferon gamma release assays for diagnosing latent tuberculosis infection in patients with chronic inflammatory arthritis

Cited by 2 publications

References 0 publications

Reasons for requesting an interferon gamma release test from internal medicine and rheumatology clinics and evaluation of the results

Reasons for requesting an interferon gamma release test from internal medicine and rheumatology clinics and evaluation of the results

What Tool for Diagnosis of Latent Tuberculosis Infection in Developing Country with Tuberculosis High Burden: Interferon Gamma Release Assays <i>versus</i> Tuberculin Skin Test in Burkina Faso

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Concordance between the tuberculin skin test and interferon gamma release assays for diagnosing latent tuberculosis infection in patients with chronic inflammatory arthritis

Cited by 2 publications

References 0 publications

Reasons for requesting an interferon gamma release test from internal medicine and rheumatology clinics and evaluation of the results

Reasons for requesting an interferon gamma release test from internal medicine and rheumatology clinics and evaluation of the results

What Tool for Diagnosis of Latent Tuberculosis Infection in Developing Country with Tuberculosis High Burden: Interferon Gamma Release Assays &lt;i&gt;versus&lt;/i&gt; Tuberculin Skin Test in Burkina Faso

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What Tool for Diagnosis of Latent Tuberculosis Infection in Developing Country with Tuberculosis High Burden: Interferon Gamma Release Assays <i>versus</i> Tuberculin Skin Test in Burkina Faso