Concurrent Aerobic and Resistance Training Has Anti‐Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF‐1 in Late Middle‐Aged Type 2 Diabetic Patients

Annibalini, Giosuè; Lucertini, Francesco; Agostini, Deborah; Vallorani, Luciana; Gioacchini, Annamaria; Barbieri, Elena; Guescini, Michele; Casadei, Lucia; Passalia, Annunziata; Sal, Marta Del; Piccoli, Giovanni; Andreani, Mauro; Federici, Ario; Stocchi, Vilberto

doi:10.1155/2017/3937842

Cited by 57 publications

(58 citation statements)

References 62 publications

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“…On the other hand, there was no significant change in ADP or CRP. 36 In the present study, ADP levels (+152.73%) increased, and leptin (-37.5%), IL-6 (-21.21%), TNF-α (-23.2%) and CRP (-67.03%) decreased.…”

Section: Discussionsupporting

confidence: 53%

Impact of eight weeks of concurrent training on obesity-related biochemical parameters and cardiometabolic risk factors: a case report

Mello¹,

Monteiro-Lago²,

Cardoso³

et al. 2019

AOWMC

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Objective: evaluate the impact of concurrent training (CT) on biochemical parameters and obesity-related cardiometabolic risk factors. Methods: case report of a sedentary 23-year-old male, classified as class 1 obese. Blood sample collected: glucose (GLU), glycated hemoglobin (HbA1c), total cholesterol (TC), triglycerides (TG), HDL-cholesterol fraction (HDL), LDL-cholesterol fraction (LDL), tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6), leptin (LEP) and adiponectin (ADP). In addition, VO2max, resting heart rate (HR), resting systolic and diastolic blood pressure (SBP and DBP), body mass (BM), height (HT), waist circumference (WC) and hip circumference (HC) were measured. The body mass index (BMI) and body adiposity index (BAI) were obtained by anthropometric measurements. All variables were evaluated before and after eight weeks of TC with progressive intensity, performed in three non-consecutive weekly sessions. Results: a reduction was observed in blood GLU (Δ%=-5.56), HbA1c (Δ%=-13.46), TC (Δ%=-19.05), TG (Δ%=-9.64), LDL (Δ%=-32.98), TNF-α (Δ%=-23.2), CRP (Δ%=-67.03), IL-6 (Δ%=-21.2) and LEP (Δ%=-37.5). The variables HDL (Δ%=10.5) and ADP (Δ%=152.73) exhibited an increase. A decline was observed in BM (Δ%=-1.69), WC (Δ%=-9.55), HC (Δ%=-9.17), BMI (Δ%=-1.7), BAI (Δ%=-14.24), SBP (Δ%=-4.96) and HR (Δ%=-18.67). The VO 2 max showed an increase (Δ%=16.83). Conclusion: a concurrent 8-week training program had beneficial effects on biochemical parameters and obesity-related cardiometabolic risk factors.

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Section: Discussionsupporting

confidence: 53%

Impact of eight weeks of concurrent training on obesity-related biochemical parameters and cardiometabolic risk factors: a case report

Mello¹,

Monteiro-Lago²,

Cardoso³

et al. 2019

AOWMC

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“…However, how FoxO activation is influenced by exercise remains unclear. In addition, cytokines such as those that we and others have found to be regulated by exercise and training [ 14 , 102 – 104 ] have been reported to have direct and indirect effects on cellular stress responses modulated by acetylation/deacetylation reactions, and these effects can be further modified by cortical steroids, which exercise dramatically induces [ 105 ].…”

Section: Evidence Of Mtor Modulation By Exercise In Tnbcmentioning

confidence: 99%

New Insights into the Role of Exercise in Inhibiting mTOR Signaling in Triple‐Negative Breast Cancer

Agostini

Natalucci

Baldelli

et al. 2018

Oxidative Medicine and Cellular Longevity

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Triple-negative breast cancer (TNBC) does not express estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 and is characterized by its aggressive nature, lack of targets for targeted therapies, and early peak of recurrence. Due to these specific characteristics, chemotherapy does not usually yield substantial improvements and new target therapies and alternative strategies are needed. The beneficial responses of TNBC survivors to regular exercise, including a reduction in the rate of tumor growth, are becoming increasingly apparent. Physiological adaptations to exercise occur in skeletal muscle but have an impact on the entire body through systemic control of energy homeostasis and metabolism, which in turn influence the TNBC tumor microenvironment. Gaining insights into the causal mechanisms of the therapeutic cancer control properties of regular exercise is important to improve the prescription and implementation of exercise and training in TNBC survivors. Here, we provide new evidence of the effects of exercise on TNBC prevention, control, and outcomes, based on the inhibition of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (PKB also known as Akt)/mammalian target of rapamycin (mTOR) (PI3K-Akt-mTOR) signaling. These findings have wide-ranging clinical implications for cancer treatment, including recurrence and case management.

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“…In fact, aerobic or cardiorespiratory exercise programs are the most frequently implemented [ 27 ]. However, other studies have analyzed the impact of resistance training or a combination of resistance and aerobic training on low-grade chronic inflammation in people with obesity and overweight [ 28 , 29 , 30 , 31 ]. Even methodologies of highly specialized training with high-intensity interval training (HIIT) have been implemented to compare their effect on the inflammatory state of people with obesity and normal weight [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in Lipoinflammation Markers in People with Obesity after a Concurrent Training Program: A Comparison between Men and Women

González-Jurado

Suárez-Carmona

López

et al. 2020

IJERPH

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Obesity is related to low-grade systemic inflammation. This state of inflammation is characterized by the alteration in adipokine regulation, which may lead to a situation of cardiometabolic risk. The aim of this study was to evaluate the effects of a concurrent training program on markers of lipoinflammation in adult people with obesity, comparing the response to the training between men and women. A quasi-experimental, quantitative, and longitudinal study with a pre–post intervention was conducted. An 8-week concurrent training program was carried out, in which 26 individuals with obesity participated (mean ± SD; age = 46.38 ± 4.66) (BMI = 36.05 ± 4.99) (12 men and 14 women). Before and after the intervention period, blood samples were taken by percutaneous puncture. The blood levels of adiponectin and leptin were evaluated. Significant differences were obtained in the adiponectin–leptin ratio (A/L ratio) of the entire sample (p = 0.009, ES = 0.53), which indicates a decrease in the risk of cardiovascular diseases and lipoinflammation. There were no significant differences in the improvements observed after the training in A/L ratio between women (A/L change = +63.5%) and men (A/L change= +59.2%). It can be concluded that the combination of aerobic exercise and resistance training induced an improvement in markers of lipoinflammation and cardiometabolic risk in the individuals with obesity evaluated in this study.

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Concurrent Aerobic and Resistance Training Has Anti‐Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF‐1 in Late Middle‐Aged Type 2 Diabetic Patients

Cited by 57 publications

References 62 publications

Impact of eight weeks of concurrent training on obesity-related biochemical parameters and cardiometabolic risk factors: a case report

Impact of eight weeks of concurrent training on obesity-related biochemical parameters and cardiometabolic risk factors: a case report

New Insights into the Role of Exercise in Inhibiting mTOR Signaling in Triple‐Negative Breast Cancer

Changes in Lipoinflammation Markers in People with Obesity after a Concurrent Training Program: A Comparison between Men and Women

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