Concurrent dengue and malaria infection in Lahore, Pakistan during the 2012 dengue outbreak

Assir, Muhammad Zaman Khan; Masood, Muhammad Adnan; Ahmad, Hafiz Ijaz

doi:10.1016/j.ijid.2013.09.007

Cited by 41 publications

(68 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Present study also reports only 2 cases of concurrent dengue and malaria infections. In contrast to our findings a study from Lahore, Pakistan reported high proportion of denguemalaria co-infections (17/52) during 2012 outbreaks of Dengue infection (12). Both RDTs were found to be negative in isolated malaria infections in present study.…”

Section: Resultscontrasting

confidence: 99%

“…Dengue NS1 antigen and Dengue specific IgA antibody based assays have been shown to be useful during early febrile days. [5][6][7][8][9][10][11][12][13][14][15][16][17] ELISA and ICT based NS1 assay have been used as a diagnostic tool during febrile phase till defervescence (1 -9 days of fever onset) however, due to presence of virus -IgG immunocomplexs this assay has shown to be less sensitive in secondary infection as compared to primary infections 18,19 and may give false negative results in dengue endemic and hyperendemic areas. Studies comparing sensitives and specificities of IgA and NS1 reported dengue IgA to be more sensitive during early febrile phase of both primary and secondary dengue infection.…”

Section: -416mentioning

confidence: 99%

See 1 more Smart Citation

Dengue Rapid Diagnostic Tests; Evaluation of Utility in a Tertiary Care Hospital

Kidwai

Ara

Ghaznawi

et al. 2017

TPMJ

View full text Add to dashboard Cite

ABSTRACT… Objectives:To determine the point of care role of dengue IgA and Dengue IgM / IgG rapid diagnostic tests (RDTs) in a tertiary care setting in terms of day of onset of illness at presentation and frequency of positive RDTs in dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Study Design: Cross-sectional study. Setting: Abbasi Shaheed Hospital, Karachi. Period: August-2014 to January-2016. Method: Patients aged 13years and above with acute febrile illness, fulfilling the WHO case definition criteria of probable DF and DHF were included. Two immunochromatograpic (ICT) based RDTs, Assure dengue IgA and Panbio Dengue Duo Cassette (IgM / IgG) were used. Dengue IgA was employed in all patients from day 2 of illness whereas IgM / IgG was employed after day 4 of onset of fever. Result: Among 174 probable cases, 108 (62%) presented between 2 -5 days of onset of fever, among whom 87 (80.5%) were found to be dengue IgA positive. Sixty-nine (39.65%) patients had DHF, among whom 97.1% were seropositive for IgA. Of 118 patients presented after 4 days of onset of illness, 59.3% were positive by IgM / IgG rapid assay. Conclusion: Considering the higher frequency of secondary dengue and DHF in dengue endemic-hyperendemic regions, IgA based ICT might be a helpful diagnostic assay for early diagnosis of dengue infection.

show abstract

Section: Resultscontrasting

confidence: 99%

Section: -416mentioning

confidence: 99%

Dengue Rapid Diagnostic Tests; Evaluation of Utility in a Tertiary Care Hospital

Kidwai

Ara

Ghaznawi

et al. 2017

TPMJ

View full text Add to dashboard Cite

show abstract

“…There were isolated case reports in India [7, 20–24], East Timor [12], Japan [17], Bangladesh [13], Indonesia [14], Malaysia [16], and Cambodia [15]. Following that, a series of cases were reported in French Guiana [25, 26], Brazil [11, 27], India [28–30], Bangladesh [31], Pakistan [10], Peru [32], and Kenya [33]. …”

Section: Discussionmentioning

confidence: 99%

“…Studies were conducted regionally and it was noticed that the incidence of dual malaria-dengue co-infection among patients presented with acute febrile illness was actually higher than expected, ranging from 1 to 33% of the acute febrile illness state in different countries [8–10, 26, 33]. This increase may be explained by the overlap of vectors in endemic areas and increased prevalence of dengue fever [9, 26].…”

Section: Discussionmentioning

confidence: 99%

“…Since the first reported case of dengue-malaria co-infection in France in 2005 [6], more cases have been reported in India [7, 8], Pakistan [9, 10], Brazil [11], East Timor [12], Bangladesh [13], Indonesia [14], Cambodia [15], Malaysia [16], and Japan [17]. Among these reported cases, only Plasmodium falciparum and Plasmodium vivax were involved.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The dangers of accepting a single diagnosis: case report of concurrent Plasmodium knowlesi malaria and dengue infection

Chong

Zaini

Suraiya

et al. 2017

Malar J

View full text Add to dashboard Cite

BackgroundDengue and malaria are two common, mosquito-borne infections, which may lead to mortality if not managed properly. Concurrent infections of dengue and malaria are rare due to the different habitats of its vectors and activities of different carrier mosquitoes. The first case reported was in 2005. Since then, several concurrent infections have been reported between the dengue virus (DENV) and the malaria protozoans, Plasmodium falciparum and Plasmodium vivax. Symptoms of each infection may be masked by a simultaneous second infection, resulting in late treatment and severe complications. Plasmodium knowlesi is also a common cause of malaria in Malaysia with one of the highest rates of mortality. This report is one of the earliest in literature of concomitant infection between DENV and P. knowlesi in which a delay in diagnosis had placed a patient in a life-threatening situation.Case presentationA 59-year old man staying near the Belum-Temengor rainforest at the Malaysia–Thailand border was admitted with fever for 6 days, with respiratory distress. His non-structural protein 1 antigen and Anti-DENV Immunoglobulin M tests were positive. He was treated for severe dengue with compensated shock. Treating the dengue had so distracted the clinicians that a blood film for the malaria parasite was not done. Despite aggressive supportive treatment in the intensive care unit (ICU), the patient had unresolved acidosis as well as multi-organ failure involving respiratory, renal, liver, and haematological systems. It was due to the presentation of shivering in the ICU, that a blood film was done on the second day that revealed the presence of P. knowlesi with a parasite count of 520,000/μL. The patient was subsequently treated with artesunate-doxycycline and made a good recovery after nine days in ICU.ConclusionsThis case contributes to the body of literature on co-infection between DENV and P. knowlesi and highlights the clinical consequences, which can be severe. Awareness should be raised among health-care workers on the possibility of dengue-malaria co-infection in this region. Further research is required to determine the real incidence and risk of co-infection in order to improve the management of acute febrile illness.

show abstract

Investigation of dengue–malaria coinfection among febrile patients consulting at Ngaoundere Regional Hospital, Cameroon

Galani

Mapouokam

Simo

et al. 2021

Journal of Medical Virology

View full text Add to dashboard Cite

This study aimed at evaluating the seroprevalence of dengue among malarious patients consulting at the Ngaoundere Regional Hospital. During 2 months and a half, 174 participants were recruited and their blood samples were screened for Plasmodium spp and then for Dengue virus (DENV) infection using rapid diagnostic tests. Also, hematological asparameters were measured using a hematology autoanalyzer. Among patients tested, 134 (77.01%) were malaria‐positive, and 12/134 (8.95%) were coinfected. In this population, 8/12 (66.67%) were only anti‐DENV IgM‐positive, 3/12 (25%) were both NS1 and anti‐DENV IgM positive, and 1/12 (8.33%) were anti‐DENV IgG‐positive. Furthermore, women were more affected (58.3%) than men (41.7%). The most affected age groups were young people aged less than or equal to 15 years (33.3%) and adults aged between 30 and 45 years (33.3%). A significant association (p < .05; odds ratio [OR] = 5.16) was found between the age range (30–45) and dengue–malaria coinfection. Similarly, we noted a significant association between the coinfection, and joint pain (p < .05; OR = 6.15), fatigue (p < .01; OR = 5.74), and chills (p < .05; OR = 0). Analysis of hematologic parameters showed a significant decrease (p < .001) in platelets in coinfected patients compared with monoinfected patients. In conclusion, dengue–malaria coinfection is a reality in Ngaoundere city and associated with the appearance of clinical features which predict the disease severity.

show abstract

Concurrent dengue and malaria infection in Lahore, Pakistan during the 2012 dengue outbreak

Abstract: The rate of isolated malaria and dengue-malaria co-infection was high in probable cases of dengue fever in our study. Except for jaundice, we could not find any significant between-group differences in the severity of the disease.

Cited by 41 publications

References 7 publications

Dengue Rapid Diagnostic Tests; Evaluation of Utility in a Tertiary Care Hospital

Dengue Rapid Diagnostic Tests; Evaluation of Utility in a Tertiary Care Hospital

The dangers of accepting a single diagnosis: case report of concurrent Plasmodium knowlesi malaria and dengue infection

Investigation of dengue–malaria coinfection among febrile patients consulting at Ngaoundere Regional Hospital, Cameroon

Contact Info

Product

Resources

About