Concurrent diabetic ketoacidosis and pancreatitis in Paediatric acute lymphoblastic leukemia receiving L-asparaginase

Jameel, Patel Zeeshan; Lohiya, Sham; Dongre, Amol; Damke, Sachin; Lakhkar, Bhushan N.

doi:10.1186/s12887-020-02136-3

Cited by 24 publications

(20 citation statements)

References 32 publications

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“…However, the usage of these drugs is often accompanied with undesired side effects such as abdomen pain, mood swings, depression, breathing difficulties, nausea and fatigue [ 56 ]. Hematological toxicity, gastrointestinal toxicity ototoxicity, hepatotoxicity, cardiotoxicity and neurotoxicity are also noted following the use of chemotherapeutic agents [ 57 , 58 , 59 , 60 , 61 ]. If the treatments with damnacanthal and nordamnacanthal have fewer health consequences than the drugs currently in use in the clinical setting, they have high potential to be established as anticancer drugs.…”

Section: Discussionmentioning

confidence: 99%

Anticancer Potential of Damnacanthal and Nordamnacanthal from Morinda elliptica Roots on T-lymphoblastic Leukemia Cells

et al. 2021

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Background: This study reports on the cytotoxic properties of nordamnacanthal and damnacanthal, isolated from roots of Morinda elliptica on T-lymphoblastic leukaemia (CEM-SS) cell lines. Methods: MTT assay, DNA fragmentation, ELISA and cell cycle analysis were carried out. Results: Nordamnacanthal and damnacanthal at IC50 values of 1.7 μg/mL and10 μg/mL, respectively. At the molecular level, these compounds caused internucleosomal DNA cleavage producing multiple 180–200 bp fragments that are visible as a “ladder” on the agarose gel. This was due to the activation of the Mg2+/Ca2+-dependent endonuclease. The induction of apoptosis by nordamnacanthal was different from the one induced by damnacanthal, in a way that it occurs independently of ongoing transcription process. Nevertheless, in both cases, the process of dephosphorylation of protein phosphates 1 and 2A, the ongoing protein synthesis and the elevations of the cytosolic Ca2+ concentration were not needed for apoptosis to take place. Nordamnacanthal was found to have a cytotoxic effect by inducing apoptosis, while damnacanthal caused arrest at the G0/G1 phase of the cell cycle. Conclusion: Damnacanthal and nordamnacanthal have anticancer properties, and could act as potential treatment for T-lymphoblastic leukemia.

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Section: Discussionmentioning

confidence: 99%

Anticancer Potential of Damnacanthal and Nordamnacanthal from Morinda elliptica Roots on T-lymphoblastic Leukemia Cells

et al. 2021

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“…Repaglinide did not raise transaminase levels in five patients with chronic viral hepatitis [31,[33][34][35][36][37][38][39][40].…”

Section: Pharmacological Interventionsmentioning

confidence: 99%

Study on Post Liver Transplant Diabetes Mellitus (PLTDM): Pathogenesis and Risk Factors

Lothe

Gomase

Mohale

2021

JPRI

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Post-liver transplantation Diabetes Mellitus (DM) or PLTDM, affects 30 % of liver transplant patients and is linked to an elevated risk of death & a variety of adverse consequences. PLTDM is a multi-cause disease, however, the use of immunosuppressive drugs from the calcineurin inhibitor (CNI) family is the primary risk factor (tacrolimus and cyclosporine). Other variables, including before-transplant obesity, alcoholic independent steatohepatitis, & hepatitis C virus infection, can enhance the incidence of Post Liver Transplant DM. Only when the dosages of Calcineurin inhibitor & steroids have been stabilized & the stress after the operation has been alleviated should a diagnosis of PLTDM be made. Insulin secretory dysfunction is the most common complication caused by CNI. To enhance long-term success for both the patient and the transplant, plasma glucose management must begin soon after the surgery. Metformin and DPP-4 inhibitors, among the more well-known antidiabetics, have a notably non-malignant profile into the setting of Post Liver Transplant DM & are recommended oral medicines for large duration treatment. Insulin treatment is another viable treatment option for the disorder's underlying pathophysiological problem. There is yet little information on the effects of newer antidiabetic families on Post Liver Transplant DM. With immunosuppressant medicines, the physician managing diabetes, dyslipidemia, and hypertension following transplant must be aware of the increased risk of drug-drug interactions and infections. The increased risk of fluctuating and decreased renal function, which can lead to hypoglycemia, must be included in treatment goals and treatments. While research is underway to develop ways to prevent PTDM, it is critical that immunosuppressive regimes be chosen based on their ability to prolong graft survival rather than to avoid PTDM.

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“…The advantages of intensive therapy were larger the shorter the period of IDDM at the time of enrolment. a development are removed in the HbA1c range obtained by DCCT intensive therapy [19,20]. However, the change in risk over time differed dramatically across the treatment groups, with the risk in the standard group increasing over time in the trial while maintaining essentially.…”

Section: Pregnancy Effectmentioning

confidence: 99%

A Brief Overview of Diabetic Retinopathy

Rajput

Mankar

2021

JPRI

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Diabetic Retinopathy (DR) and diabetic macular oedema are caused by multiple retina's capillary changes and increased retinal blood vessels permeability, which contributes to the emergence These treatments aren't always beneficial in all patients, and possible adverse effects can linger in a considerable number of people. One of the mechanisms that is found is the plasma kallikrein-kinin system (KKS). The formation of intraocular KKS causes retina’s capillary permeability, vascular dilation, and retinal thickening in preclinical investigations. possibly distinct physiologic pathways, according to proteomic study from the vitreous of eyes with DME. Furthermore, proteins linked to substantially more closely linked to the KKS route than discovered to be an effective way to reduce diabetic mice in preclinical investigations. An early phase I human study of a new plasma KKS inhibitor for the management of DME is now underway to assess the approach's safety and serve as a first step in translating basic science discoveries into a novel therapeutic involvement. Many years of study of the etiology plus treatment has transformed our understanding of the condition. Because neurodegenerative illness precedes and coexists with microvascular alterations, diabetic retinopathy is characterised as a neurovascular disease rather than a capillary disease. The intricacies of the pathways implicated in various phases of disease severity, on the other hand, continue to be a difficult challenge for drug development. Laser photocoagulation is now one of the best investigation for treating proliferative diabetic retinopathy, however it is rapidly being phased out for diabetic macular oedema. Inhibitors of vascular endothelial growth factor, which were recently discovered, are changing the treatment of diabetic retinopathy, particularly diabetic macular edema . Anyhow, anti-vascular endothelial growth factor medicines do not work in all individuals, highlighting the reality that diabetic retinopathy is a complex illness. To improve our perceptive of how retinal anatomy affects visual function, more research is needed. This is expected to contribute to a greater knowledge of the disease phenotype based on therapy reactions to specific drugs, and also the creation of a strategy to improve the company of different phases of seriousness. In the Diabetes control and complications trial (DCCT) main preventive and secondary intervention cohorts were found to be older at baseline than the WESDR groups, with an elderly age of finding, a lower haemoglobin A1c (HbA1c) level, and more recurrent injections and monitor, but there were few other significant changes.

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Concurrent diabetic ketoacidosis and pancreatitis in Paediatric acute lymphoblastic leukemia receiving L-asparaginase

Cited by 24 publications

References 32 publications

Anticancer Potential of Damnacanthal and Nordamnacanthal from Morinda elliptica Roots on T-lymphoblastic Leukemia Cells

Anticancer Potential of Damnacanthal and Nordamnacanthal from Morinda elliptica Roots on T-lymphoblastic Leukemia Cells

Study on Post Liver Transplant Diabetes Mellitus (PLTDM): Pathogenesis and Risk Factors

A Brief Overview of Diabetic Retinopathy

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