Concurrent measurement of skeletal muscle blood flow during exercise with diffuse correlation spectroscopy and Doppler ultrasound

Bangalore-Yogananda, Chandan-Ganesh; Rosenberry, Ryan; Soni, Sagar; Liu, Hanli; Nelson, Michael D.; Tian, Fenghua

doi:10.1364/boe.9.000131

Cited by 21 publications

(26 citation statements)

References 28 publications

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“…Doppler ultrasound, arterial blood pressure, heart rate and DCS-NIRS-derived variables were measured throughout rest, exercise and post-exercise recovery. To minimize muscle fibre motion artifact during exercise, DCS-NIRS data were recorded only during the relaxation phase of the handgrip duty cycle, as previously described (Gurley et al 2012;Bangalore-Yogananda et al 2018 For Experimental Aim 1, a one-way repeated measures analysis of variance (ANOVA) was used to test for differences between resting and exercise values for all physiological and NIRS-DCS-derived variables. For Experimental Aim 2, a two-way repeated measures ANOVA was used to test for main effects of time (rest versus exercise) and condition (arm above versus below the level of the heart) as well as an interaction effect for all physiological and NIRS-DCS-derived variables.…”

Section: Discussionmentioning

confidence: 99%

“…; Bangalore‐Yogananda et al . ). Accordingly, brachial artery blood flow measurements were also made during the relaxation phase of the handgrip duty cycle, to match DCS.…”

Section: Methodsmentioning

confidence: 97%

“…Moreover, validation of DCS against conventional measures of convective oxygen delivery -in exercising skeletal muscle -is also limited. In fact, to our knowledge, we have been the only lab to address this knowledge gap (Bangalore-Yogananda et al 2018), showing excellent agreement between DCS-derived blood flow index and Doppler-derived brachial artery blood flow during rhythmic handgrip exercise. The current data confirm and extend these prior observations in two important ways.…”

Section: Experimental Aimmentioning

confidence: 97%

“…A detailed description of DCS methods is outlined in a previous report (Bangalore-Yogananda et al 2018). Briefly, DCS determines a blood flow index (BFI) based on the autocorrelation function of light reflectance.…”

Section: Dcs Measurementsmentioning

confidence: 99%

“…Diffuse correlation spectroscopy (DCS) is emerging as a powerful new tool to assess skeletal muscle perfusion (Gurley et al 2012;Henry et al 2015;Baker et al 2017;Carp et al 2017;Shang et al 2017;Bangalore-Yogananda et al 2018;Hammer et al 2018). DCS is completely non-invasive, has excellent temporal resolution (Bi et al 2015) and has been validated in a variety of organs and tissues against several different standards, including laser Doppler (Shang et al 2011), xenon-CT (Kim et al 2014), fluorescent microsphere flow measurements (Zhou et al 2009) and arterial spin labelled-MRI (Yu et al 2007).…”

Section: Introductionmentioning

confidence: 99%

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Studies into the determinants of skeletal muscle oxygen consumption: novel insight from near‐infrared diffuse correlation spectroscopy

Tucker

Rosenberry

Trojacek

et al. 2019

The Journal of Physiology

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Key points Diffuse correlation spectroscopy (DCS) is emerging as a powerful tool to assess skeletal muscle perfusion. Near‐infrared spectroscopy (NIRS) is an established technique for characterizing the transport and utilization of oxygen through the microcirculation. Here we compared a combined NIRS–DCS system with conventional measures of oxygen delivery and utilization during handgrip exercise. The data show good concurrent validity between convective oxygen delivery and DCS‐derived blood flow index, as well as between oxygen extraction at the conduit and microvascular level. We then manipulated forearm arterial perfusion pressure by adjusting the position of the exercising arm relative to the position of the heart. The data show that microvascular perfusion can be uncoupled from convective oxygen delivery, and that tissue saturation seemingly compensates to maintain skeletal muscle oxygen consumption. Taken together, these data support a novel role for NIRS–DCS in understanding the determinants of muscle oxygen consumption at the microvascular level. Abstract Diffuse correlation spectroscopy (DCS) is emerging as a powerful tool to assess skeletal muscle perfusion. Combining DCS with near‐infrared spectroscopy (NIRS) introduces exciting possibilities for understanding the determinants of muscle oxygen consumption; however, no investigation has directly compared NIRS–DCS to conventional measures of oxygen delivery and utilization in an exercising limb. To address this knowledge gap, nine healthy males performed rhythmic handgrip exercise with simultaneous measurements by NIRS–DCS, Doppler blood flow and venous oxygen content. The two approaches showed good concurrent validity, with directionally similar responses between: (a) Doppler‐derived forearm blood flow and DCS‐derived blood flow index (BFI), and (b) venous oxygen saturation and NIRS‐derived tissue saturation. To explore the utility of combined NIRS–DCS across the physiological spectrum, we manipulated forearm arterial perfusion pressure by altering the arm position above or below the level of the heart. As expected, Doppler‐derived skeletal muscle blood flow increased with exercise in both arm positions, but with markedly different magnitudes (below: +424.3 ± 41.4 ml/min, above: +306 ± 12.0 ml/min, P = 0.002). In contrast, DCS‐derived microvascular BFI increased to a similar extent with exercise, regardless of arm position (P = 0.65). Importantly, however, the time to reach BFI steady state was markedly slower with the arm above the heart, supporting the experimental design. Notably, we observed faster tissue desaturation at the onset of exercise with the arm above the heart, resulting in similar muscle oxygen consumption profiles throughout exercise. Taken together, these data support a novel role for NIRS–DCS in understanding the determinants of skeletal muscle oxygen utilization non‐invasively and throughout exercise.

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Section: Discussionmentioning

confidence: 99%

“…; Bangalore‐Yogananda et al . ). Accordingly, brachial artery blood flow measurements were also made during the relaxation phase of the handgrip duty cycle, to match DCS.…”

Section: Methodsmentioning

confidence: 97%

Section: Experimental Aimmentioning

confidence: 97%

Section: Dcs Measurementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Studies into the determinants of skeletal muscle oxygen consumption: novel insight from near‐infrared diffuse correlation spectroscopy

Tucker

Rosenberry

Trojacek

et al. 2019

The Journal of Physiology

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Blood Flow of the Infraspinatus Muscle in Individuals With and Without Shoulder Pain and Myofascial Trigger Points

Brown,

Kearns,

Hedges

et al. 2024

J of Ultrasound Medicine

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ObjectivesMyofascial trigger points (MTrPs) are potential contributors to shoulder pain and can lead to local ischemia and hypoxia, thus causing pain. Color Doppler ultrasound (US) has been used to examine the vascular environment around MTrPs, but has not been used to examine blood flow impairments in patients with shoulder pain and MTrPs. The reliability of color Doppler US for measuring infraspinatus muscle blood flow also has not been established. This study aimed to investigate differences in blood flow between individuals with and without shoulder pain and the reliability of Doppler US for measuring infraspinatus muscle blood flow.MethodsForty participants were enrolled, 20 with shoulder pain and MTrPs and 20 without. Color Doppler US examination was performed twice on each participant to measure peak systolic velocity (PSV), end‐diastolic velocity (EDV), resistive index (RI), and pulsatile index (PI) of the infraspinatus muscle.ResultsThe symptomatic participants had significantly higher PSV (ie, impaired blood flow) than the asymptomatic participants. There were no significant between‐group differences in EDV, RI, and PI. The results also demonstrated good‐to‐excellent intra‐rater reliability for color Doppler US measurements of PSV, EDV, RI, and PI for both groups.ConclusionThis study demonstrated differences in blood flow near MTrPs in the infraspinatus muscle between individuals with and without shoulder pain. It also established good‐to‐excellent reliability of color Doppler US in measuring infraspinatus muscle blood flow. These findings suggest color Doppler US is a useful tool to identify vascular impairments for shoulder pain associated with MTrPs.

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Towards high-performance deep learning architecture and hardware accelerator design for robust analysis in diffuse correlation spectroscopy

Zang,

Wang,

Pan

et al. 2025

Computer Methods and Programs in Biomedicine

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Concurrent measurement of skeletal muscle blood flow during exercise with diffuse correlation spectroscopy and Doppler ultrasound

Cited by 21 publications

References 28 publications

Studies into the determinants of skeletal muscle oxygen consumption: novel insight from near‐infrared diffuse correlation spectroscopy

Studies into the determinants of skeletal muscle oxygen consumption: novel insight from near‐infrared diffuse correlation spectroscopy

Blood Flow of the Infraspinatus Muscle in Individuals With and Without Shoulder Pain and Myofascial Trigger Points

Towards high-performance deep learning architecture and hardware accelerator design for robust analysis in diffuse correlation spectroscopy

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