Concurrent metastatic hepatoid gland carcinoma and eosophagogastric leiomyosarcoma in a dog

ALCIGIR, TUNC Arda Selin;

doi:10.1501/vetfak_0000002601

Ankara Üniversitesi Veteriner Fakültesi Dergisi

2014

DOI: 10.1501/vetfak_0000002601

|View full text |Cite

Concurrent metastatic hepatoid gland carcinoma and eosophagogastric leiomyosarcoma in a dog

TUNC Arda Selin; ALCIGIR¹

Abstract: Summary:A 17-year-old male, mongrel dog was evaluated for a primary mass localized between perianal and sacral region and metastatic foci on lung. It was also encountered coincidentally with another mass taking place between distal esophagus and cardia of stomach and metastatic foci in kidney. In histopathological examination, perianal localization of mass and metastatic foci on lung were diagnosed as hepatoid gland carcinoma while esophagogastric mass and metastatic foci in kidney were diagnosed as leiomyosar… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2017

2023

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Cytokeratin Profiles of Canine Anal Sac and Hepatoid Gland Neoplasms

2018

View full text Add to dashboard Cite

Ten adenocarcinomas of the apocrine gland of the anal sac and 11 hepatoid gland neoplasms were studied to determine the coordinate expression of cytokeratin 7 (CK7) and cytokeratin 14 (CK14) using commercially available antibodies. Hepatoid gland neoplasms included hepatoid gland adenomas, carcinomas and a single epithelioma. All 10 (100%) adenocarcinomas of the apocrine gland of the anal sac had CK7[Formula: see text]/CK14[Formula: see text] immunophenotype, whereas all 11 (100%) of hepatoid neoplasms expressed CK7[Formula: see text]/CK14[Formula: see text] immunophenotype. Hepatoid gland adenomas, carcinomas, and epithelioma could not be differentiated based on the cytokeratin immunophenotype. Hepatoid gland neoplasms could be differentiated from adenocarcinomas of the apocrine gland of the anal sac by differences in the CK7/CK14 immunophenotypes with a [Formula: see text]-[Formula: see text]. The results of this study provide further support for the use of coordinate expression of CK7/CK14 to differentiate apocrine gland adenocarcinomas of the anal sac (CK7[Formula: see text]/CK14[Formula: see text]) from hepatoid gland neoplasms (CK7[Formula: see text]/CK14[Formula: see text]).

show abstract

Cytokeratin Profiles of Canine Anal Sac and Hepatoid Gland Neoplasms

2018

View full text Add to dashboard Cite

show abstract

First study on the immunohistochemical expression of cyclooxygenase-2 and clinicopathological association in canine hepatoid gland neoplasms

et al. 2022

View full text Add to dashboard Cite

Background and Aim: Hepatoid gland neoplasms (HGNs) constitute one of the most common cutaneous tumors that arise from perianal glands in dogs and are clinically characterized by rapid growth. Cyclooxygenase-2 (COX-2), the inducible form of the enzyme, is associated with several hallmarks of tumorigenesis. Its expression has been confirmed in several human and animal neoplastic tissues, but there are no reports in hepatoid gland tissues. Therefore, this study aimed to investigate COX-2 immunoexpression in canine HGNs, compare the expression among groups of normal hepatoid glands, hepatoid gland adenomas (HGAs), hepatoid gland epitheliomas (HGEs), and hepatoid gland carcinomas (HGCs), and assess the association of the COX-2 expression with clinicopathological features. Materials and Methods: Sixty-one formalin-fixed paraffin-embedded canine hepatoid gland tissues (20 samples of HGAs, 16 of HGEs, 15 of HGCs, and 10 of normal hepatoid glands) were analyzed for COX-2 expression using immunohistochemistry with scoring for percentage positivity and intensity. Multiple comparisons of COX-2 expression among normal and neoplastic hepatoid glands and the associations between COX-2 expression and clinicopathological features were analyzed. Results: Cyclooxygenase-2 expression was not detected in 60% of normal hepatoid glands and 25% of HGAs. Seventy-five percent of HGAs had a weak expression, while 43.7% and 56.3% of HGEs showed weak and moderate expression, respectively. The expression of HGCs ranged from weak (13.3%) to moderate (33.3%) and strong (53.3%). The immunoreactivity score of COX-2 labeling was significantly different among the normal and neoplastic hepatoid glands (p < 0.0001). The highest score was observed in the HGCs. Only in HGCs, the strong COX-2 expression was significantly associated with some clinicopathological features, including tissue invasion (p = 0.007) and necrosis (p = 0.029). Conclusion: These results suggest that COX-2 may play a role in the modulation of neoplastic cell growth. These preliminary data lead to further investigation on the potential of COX-2 expression as a prognostic indicator and COX-2 inhibitors for canine HGCs treatment.

show abstract

Bir Köpekte Vajinal Leyomiyosarkom

Köse¹

2017

Atatürk Üniversitesi Veteriner Bilimleri Dergisi

View full text Add to dashboard Cite

Öz: Bu olguda kısırlaştırılmış bir köpekte vajinal leyomiyosarkomun tanımlanması amaçlanmıştır. Olgunun materyalini vulvasından sarkan bir kitle şikayeti ile kliniğimize getirilen melez erişkin dişi bir köpek oluşturdu. Köpeğin anamnez bilgilerinde daha önce kısırlaştırılmış olduğu ve son iki aydır vulvasından sarkan bir kitlenin olduğu öğrenildi. Fiziksel muayenede köpeğin genel durumunun iyi olduğu belirlendi. Vajinal muayenede; vulvadan dışarı sarkan, saplı, pembemsi renkli sert bir kitle tespit edildi. Kitlenin köpeğin vajinasının dorsal duvarından köken aldığı belirlendi. Kitleye tümöral bir yapı tanısı konularak operasyonla uzaklaştırılmasına karar verildi. Makroskobik olarak 5.6x3.2x1.7 cm boyutlarında, 43 gr ağırlığında, pembemsi beyaz renkte, elastik kıvamlı kitle gözlendi. Mikroskobik olarak hiperkromatik çekirdekli, birbirine çaprazlar yapan, anaplastik şekilli, iğsi ve yuvarlak şekilli hücreler arasında çok çekirdekli dev hücreleri, nekroz alanları ve yer yer mitozlar dikkati çekti. Makroskobik ve mikroskobik özelliklerine göre tümöre leyomiyosarkom tanısı kondu. Sonuç olarak; vajinal leyomiyosarkomun köpeklerde nadir görülmesi ve köpeğin kısırlaştırılmış olması nedeniyle olgunun makroskobik ve histopatolojik bulgularının literatür verilere katkı sağlayabileceği düşünüldü.Abstract: In this case report it was aimed to determine vaginal leiomyosarcoma in a neutered bitch. The material of this case was an adult mixed breed neutered bitch brought to our clinic complaint with a mass hanging from the vulva. In the history, it was learnt that bitch had been neutered before, and there had been a mass hanging from the vulva since last two months. The condition of the bitch was determined to be good in the physical examination. In the vaginal examination, stalked, pinkish a hard mass hanging from the vulva was detected. It was determined that the mass was originated from dorsal vaginal wall of the bitch. It was decided to remove with operation by diagnosing as a tumoral structure. Macroscopically 5.6x3.2x1.7 cm in diameter, 43 gr in weight, pinky-white in colour, elastic in consistence mass was observed. Microscopically hyperchoromatic nucleus, crossed each other, anaplastic, round-shaped spindle cells include multinucleated giant cells, necrosis and mitotic figures were noted in places. According to macroscopic and microscopic features, the tumor was diagnosed as leiomyosarcoma. Consequently, because both the vaginal leiomyosarcoma rarely seen in the dog and occurenced in sterilized dog, macroscopic and histopathologic findings of the case were considered to be able to contribute to the literature.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Concurrent metastatic hepatoid gland carcinoma and eosophagogastric leiomyosarcoma in a dog

Cited by 4 publications

References 17 publications

Cytokeratin Profiles of Canine Anal Sac and Hepatoid Gland Neoplasms

Cytokeratin Profiles of Canine Anal Sac and Hepatoid Gland Neoplasms

First study on the immunohistochemical expression of cyclooxygenase-2 and clinicopathological association in canine hepatoid gland neoplasms

Bir Köpekte Vajinal Leyomiyosarkom

Contact Info

Product

Resources

About