2008
DOI: 10.1002/jbm.a.32288
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Concurrent release of admixed antimicrobials and salicylic acid from salicylate‐based poly(anhydride‐esters)

Abstract: A polymer blend consisting of antimicrobials (chlorhexidine, clindamycin, and minocycline) physically admixed at 10% by weight into a salicylic acid-based poly (anhydride-ester) (SA-based PAE) was developed as an adjunct treatment for periodontal disease. The SA-based PAE/ antimicrobial blends were characterized by multiple methods, including contact angle measurements and differential scanning calorimetry. Static contact angle measurements showed no significant differences in hydrophobicity between the polyme… Show more

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Cited by 30 publications
(29 citation statements)
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“…Cell uptake of chloroquine was 2.3 fold higher in P-MDCK cells than wild type MDCK cells (p value = 1.598E −05 , n = 6); whereas, there was no significant difference in cell uptake of salicylic acid between transfected and wild type cells (Figure 5). The cell uptake of chloroquine was significantly higher than salicylic acid in both wild type as well as transfected MDCK cells, which is due to higher lipophilicity of chloroquine 24 as compared to salicylic acid 25 .…”
Section: Resultsmentioning
confidence: 93%
See 1 more Smart Citation
“…Cell uptake of chloroquine was 2.3 fold higher in P-MDCK cells than wild type MDCK cells (p value = 1.598E −05 , n = 6); whereas, there was no significant difference in cell uptake of salicylic acid between transfected and wild type cells (Figure 5). The cell uptake of chloroquine was significantly higher than salicylic acid in both wild type as well as transfected MDCK cells, which is due to higher lipophilicity of chloroquine 24 as compared to salicylic acid 25 .…”
Section: Resultsmentioning
confidence: 93%
“…In contrast, salicylic acid. a negatively charged hydrophilic molecule 25 with a very low affinity and little or no binding to melanin pigment serves as a negative control for melanin binding 38 . Chloroquine showed 2.3-fold higher uptake in P-MDCK cells as compared to plain MDCK cells (Figure 5).…”
Section: Discussionmentioning
confidence: 99%
“…22,23 The chemical incorporation of SA enables inherent drug loading capacities up to 85% (w/w), with the ability to physically admix additional drug to obtain even higher loading. 24 …”
Section: Introductionmentioning
confidence: 99%
“…A new mode of SA delivery is possible by the chemical incorporation of SA into a polymer backbone to yield salicylate-based poly(anhydride-esters) (PAEs) [35]. The physicochemical properties of such polyanhydrides have been investigated over the last decade [514]. The ability to formulate these polymers into different geometries such as powders [6], disks [5, 9, 15], fibers [7], microspheres [10, 16], etc.…”
Section: Introductionmentioning
confidence: 99%
“…Yet, the PAEs degrade faster at temperatures above 25 °C [15] and in the presence of water (Scheme 1). Further, the PAEs are shown to be non-toxic in vitro [14] and in vivo [9, 16, 17] and, therefore, have great potential in various biomedical applications [6, 9, 13, 14, 17]. However, the polymer should meet the pharmacopeial and commercial requirement of sterility [1821].…”
Section: Introductionmentioning
confidence: 99%