Lack of understanding of flow boiling behavior in reduced gravity poses a major challenge to the development of future space vehicles utilizing two-phase thermal control systems (TCSs). A cost effective method to investigating the influence of reduced gravity on flow boiling is to perform ground experiments at different orientations relative to Earth gravity. This paper is the first part of a two-part study aimed at exploring flow boiling mechanisms of FC-72 in a rectangular channel heated along one wall or two opposite walls. Experiments are performed in vertical upflow, vertical downflow and horizontal flow, subject to large variations in mass velocity, inlet quality and wall heat flux. Detailed measurements are used to investigate the influences of orientation, and therefore gravity, on boiling curve, local and average heat transfer coefficients, and pressure drop, and their relationship with interfacial behavior is captured with high-speed video. For horizontal flow, the effects of gravity are reflected in appreciable stratification across the channel at low mass velocities, with gravity aiding vapor removal from, and liquid return to the bottom heated wall, while accumulating vapor along the top heated wall. For vertical upflow and vertical downflow, with both single-sided and double-sided heating, there is far better symmetry in vapor formation along the channel. The heat transfer coefficient shows significant variations among the different orientations and heating configurations at low mass velocities, but becomes insensitive to orientation above 800 kg/m 2 s, proving inertia around this mass velocity is effective at negating any gravity effects. For low mass velocities, pressure drops are fairly equal for vertical upflow and vertical downflow, but greater than for horizontal flows. However, fairly equal pressure drops are achieved at high mass velocities for all orientations. Overall, this study proves that gravity effects on two-phase pressure drop and two-phase heat transfer are dictated mostly by mass velocity and, to a lesser extent, by inlet quality.