2020
DOI: 10.1101/2020.01.14.904409
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Condensin I subunit Cap-G is essential for proper gene expression during the maturation of post-mitotic neurons

Abstract: AbstractThe condensin complex is essential for mitotic chromosome assembly and segregation during cell divisions, however, little is known about its function in post-mitotic, differentiated cells. Here we report a novel role for the condensin I subunit Cap-G in Drosophila neurons. We show that, despite not requiring condensin for mitotic chromosome compaction, post-mitotic neurons express Cap-G and that knockdown of Cap-G specifically in neurons (from… Show more

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Cited by 2 publications
(2 citation statements)
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“…Factors involved in the maintenance of neuronal transcriptomes during early neuronal maturation can have less severe phenotypes in fully differentiated neurons in which synapses have been formed (Hassan et al, 2020; Southall et al, 2014). This correlates with observed changes to the underlying chromatin landscape which is dynamic during differentiation and neuronal maturation (Aughey et al, 2018; Marshall and Brand, 2017).…”
Section: Resultsmentioning
confidence: 99%
“…Factors involved in the maintenance of neuronal transcriptomes during early neuronal maturation can have less severe phenotypes in fully differentiated neurons in which synapses have been formed (Hassan et al, 2020; Southall et al, 2014). This correlates with observed changes to the underlying chromatin landscape which is dynamic during differentiation and neuronal maturation (Aughey et al, 2018; Marshall and Brand, 2017).…”
Section: Resultsmentioning
confidence: 99%
“…Accessibility can be addressed experimentally using nucleases or transposases [28] but also with DamID (Figure 3B) by expressing an untethered Dam (Dam fused to a protein without chromatin affinity, e.g. GFP) which monitors chromatin accessibility and provides similar profiles as transposase-based methods with the added advantage that the aforementioned DamID protocols for tissue-specificity are immediately applicable [38,51,52]. This was applied to two different neuroblast lineages in numerous Cap-G-bound genes are either activated or repressed, suggesting that condensin I is directly involved in regulation of gene expression in the nervous system [52].…”
Section: Damid: a Rich Variety Of Genetic Approaches To Study In Vivo...mentioning
confidence: 99%