Condition of platelet factor of hemostasis system in pathogenesis of chronic periodontitis progression

Abstract

Аim. Тo evaluate the structural and functional condition of platelets as a cellular component of the hemostasis system in chronic generalized periodontitis of different severity, and to establish its role in the progression of the disease.
 Materials and Мethods. Clinical studies included 83 patients (47 men and 36 women) with chronic generalized periodontitis, comparable in age and sex, divided into three groups according to the severity of the disease: the first group (n=21) – periodontitis of mild severity; the second group (n=36) – moderate degree of severity; the third group (n=26) – severe periodontitis. Methods of the study included evaluation of the structural and functional characteristics of periodontal tissues, general hygienic condition of the oral cavity, the severity of the inflammatory process according to index parameters; study of microcirculation of periodontal tissues, determination of the evidence of oxidative processes in saliva, blood plasma, platelets, study of lipid composition of platelets.
 Results. In chronic generalized periodontitis, pathological changes in the lipid composition of platelet membranes (an increase in the percentage of lysophospholipids and free fatty acids) were associated with systemic activation of oxidative processes and of phospholipase enzyme systems, which was accompanied by an increase in their aggregation activity.The degree of increase in the activity of platelets was associated with the severity of microcirculatory disturbances in the periodontal tissues. The condition of the cellular component of the hemostasis system correlated with the severity of the pathological process in the periodontium. In severe degree of chronic periodontitis, structural and functional changes in platelets were maximal.
 Conclusion. In chronic periodontitis, the systemic activation of oxidative processes leads to a modification of the lipid composition of platelet membranes, which contributes to increase in their aggregation activity playing an important role in the induction of hypercoagulation, microcirculation disturbances and progression of inflammation in the periodontal tissues.

Comparative evaluation of the effectiveness of prosthodontic treatment using the original immediate denture design and traditional methods

“…Одной из актуальных проблем в современной стоматологии остается ортопедическое лечение пациентов с генерализованным пародонтитом, который является распространённой причиной множественной или полной утраты зубов вследствие высокой частоты его рецидивов и агрессивного течения [1]. Несмотря на активное развитие стоматологической реабилитации пациентов с использованием дентальных имплантатов, всё ещё остаётся актуальным применение методов съёмного протезирования [2].…”

Зміни Показників Ендогенної Інтоксикації У Щурів З Пародонтитом На Тлі Гіпер- Та Гіпотиреозу

“…Ïîðóøóºòüñÿ êë³òèííèé ïîä³ë ³ íàêîïè÷óþòüñÿ ³íåðòí³ ïðîäóêòè ïåðîêñèäíî¿ äåíàòóðàö³¿ ë³ï³ä³â ³ ïðîòå¿í³â [5]. ³äîìî, ùî íåêîíòðîëüî-âàí³ ðåàêö³¿ ÏÎË çäàòí³ ïðèçâîäèòè íå ò³ëüêè äî ïîðóøåííÿ îáì³ííèõ ïðîöåñ³â, à é âèêëèêàòè ñòðóêòóðí³ çì³íè â òêàíèíàõ, ïðèãí³÷óâàòè çà-õèñí³ ìåõàí³çìè îðãàí³çìó, ùî ó ñâîþ ÷åðãó ñïðèÿº àêòèâàö³¿ ì³êðîá³â, ÿê³ êîëîí³çóþòü ÿñíà ³ ïàðîäîíòàëüí³ êèøåí³ [6]. ª äàí³, ùî àêòèâà-ö³ÿ ïðîöåñ³â ÏÎË º âàaeëèâèì ïàòîô³ç³îëîã³÷íèì ìåõàí³çìîì ðîçâèòêó åíäîãåííî¿ ³íòîêñè-êàö³¿ [7].…”