Conditioned drug reward enhances subsequent spatial learning and memory in rats

Zhai, Haifeng; Zhang, Zhang-Yin; Zhao, Mei; Qiu, Yi; Ghitza, Udi E.; Lü, Lin

doi:10.1007/s00213-007-0893-x

Cited by 25 publications

(12 citation statements)

References 65 publications

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“…Indeed, exposure to either a morphine- or cocaine-conditioned context prior to training sessions enhanced learning in the Morris water maze in comparison to drug-conditioned rats that were not re-exposed to the context. Exposure to a sucrose-paired context or a context associated with naloxone-precipitated withdrawal did not alter water maze learning (Zhai et al, 2007). Therefore, exposure to contexts associated with drugs can enhance other forms of spatial learning in a manner that is not achieved by contexts associated with natural rewards or aversive states.…”

Section: Behavioral Effects Of Addictive Drugs On Learning and Memorymentioning

confidence: 99%

Aberrant learning and memory in addiction

Torregrossa

Corlett

Taylor

2011

Neurobiology of Learning and Memory

202

157

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Over the past several years, drug addiction has increasingly been accepted to be a disease of the brain as opposed to simply being due to a lack of willpower or personality flaw. Exposure to addictive substances has been shown to create enduring changes in brain structure and function that are thought to underlie the transition to addiction. Specific genetic and environmental vulnerability factors also influence the impact of drugs of abuse on the brain and can enhance the likelihood of becoming an addict. Long-lasting alterations in brain function have been found in neural circuits that are known to be responsible for normal appetitive learning and memory processes and it has been hypothesized that drugs of abuse enhance positive learning and memory about the drug while inhibiting learning about the negative consequences of drug use. Therefore, the addict's behavior becomes increasingly directed towards obtaining and using drugs of abuse, while at the same time developing a poorer ability to stop using, even when the drug is less rewarding or interferes with functioning in other facets of life. In this review we will discuss the clinical evidence that addicted individuals have altered learning and memory and describe the possible neural substrates of this dysfunction. In addition, we will explore the preclinical evidence that drugs of abuse cause a progressive disorder of learning and memory, review the molecular and neurobiological changes that may underlie this disorder, determine the genetic and environmental factors that may increase vulnerability to addiction, and suggest potential strategies for treating addiction through manipulations of learning and memory.

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Section: Behavioral Effects Of Addictive Drugs On Learning and Memorymentioning

confidence: 99%

Aberrant learning and memory in addiction

Torregrossa

Corlett

Taylor

2011

Neurobiology of Learning and Memory

202

157

View full text Add to dashboard Cite

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“…Following the eight session CPP training, the animals were tested for the expression of METH (post-conditioning test) CPP under conditions identical to those described in the pre-conditioning test. The place preference score (CPP score) was defined as the time spent in the methamphetamine-paired chamber minus that spent in the saline-paired chamber (Harris et al 2005;Wang et al 2008;Zhai et al 2007). …”

Section: Conditioned Place Preferencementioning

confidence: 99%

Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice

Wang

Zhao

et al. 2009

Psychopharmacology

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“…On the subsequent conditioning days, each rat was trained for 8 consecutive days with alternate injections of drug (morphine 5 mg/kg, s.c.) and saline (1 ml/kg, s.c.) (Bardo et al, 1995;Wang et al, 2006;Zhai et al, 2007). After each injection, rats were confined to the corresponding conditioning chambers for 45 min before returning to their home cages.…”

Section: Conditioned Place Preferencementioning

confidence: 99%

Stress Impairs Reconsolidation of Drug Memory via Glucocorticoid Receptors in the Basolateral Amygdala

Wang¹,

Zhao²,

Ghitza³

et al. 2008

J. Neurosci.

133

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Relapse to drug taking induced by exposure to cues associated with drugs of abuse is a major challenge to the treatment of drug addiction. Previous studies indicate that drug seeking can be inhibited by disrupting the reconsolidation of a drug-related memory. Stress plays an important role in modulating different stages of memory including reconsolidation, but its role in the reconsolidation of a drug-related memory has not been investigated. Here, we examined the effects of stress and corticosterone on reconsolidation of a drug-related memory using a conditioned place preference (CPP) procedure. We also determined the role of glucocorticoid receptors (GRs) in the basolateral amygdala (BLA) in modulating the effects of stress on reconsolidation of this memory. We found that rats acquired morphine CPP after conditioning, and that this CPP was inhibited by stress given immediately after re-exposure to a previously morphine-paired chamber (a reconsolidation procedure). The disruptive effect of stress on reconsolidation of morphine related memory was prevented by inhibition of corticosterone synthesis with metyrapone or BLA, but not central amygdala (

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Conditioned drug reward enhances subsequent spatial learning and memory in rats

Abstract: Our results provide the first evidence that conditioned drug reward promotes spatial learning. We speculate that this enhancement of spatial learning by the drug-paired context may promote contextual-cue-induced relapse to drug taking by facilitating exploratory drug-seeking behaviors.

Cited by 25 publications

References 65 publications

Aberrant learning and memory in addiction

Aberrant learning and memory in addiction

Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice

Stress Impairs Reconsolidation of Drug Memory via Glucocorticoid Receptors in the Basolateral Amygdala

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