Conditions of hypertrophy of the seminal vesicles in rats

Freud, J.

doi:10.1042/bj0271438

Cited by 57 publications

(12 citation statements)

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“…Weights up to 101 mg. per 100 g. body-weight were recorded. This stimulation of fibrous tissue is similar to that produced by oestrone, as described by Freud [1933].…”

Section: Discussionmentioning

confidence: 56%

Effects of Synthetic Oestrogens and Carcinogens When Administered to Rats by Subcutaneous Implantation of Crystals or Tablets

Noble¹

1939

Journal of Endocrinology

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In a preliminaryreport it was shown that the subcutaneous implantation of crystals of synthetic oestrogenic substances was followed by an inhibition of body-growth for a prolonged period in adult rats, a decreased rate of growth in young animals, and a loss of gonadotrophic hormone from the anterior pituitary gland associated with atrophy of the reproductive organs. These changes could be produced by a substance such as diethylstilboestrol, the molecular structure of which had but little resemblance to the naturally occurring oestrogens. Up to the present time no qualitative differences in the effects of oestrogens on the various parts of the body have been demonstrated. Since a large series of synthetic oestrogenic substances which had been prepared in this laboratory were available for experimental study, it has been possible to compare the effects of representative active substances from different chemical groups with closely related substances of little or no oestrogenic activity. The various oestrogenic substances which have been used in these experi¬ ments have been previously described by Cook, Dodds, Hewett, and Lawson [1934];Cook, Dodds, and Lawson [1936]; Dodds, Golberg, 6] ; Dodds and Lawson [1938] ; Dodds, Lawson, and Noble [1938].The observations of Haddow, Scott, and Scott [1937] that some hydro¬ carbons which had carcinogenic but not oestrogenic properties produced a reduction in body-growth and a decreased sexual activity in rats ap¬ peared of interest in their relationship to the problem under investigation. If the action of these non-oestrogenic hydrocarbons on growth and the pituitary gland was similar to that of oestrogenic substances, it would demonstrate that the molecular structure necessary for the production of oestrus was not essential for the production of the other effects. Experi¬ ments have been conducted, therefore, with various carcinogenic sub¬ stances.

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“…Weights up to 101 mg. per 100 g. body-weight were recorded. This stimulation of fibrous tissue is similar to that produced by oestrone, as described by Freud [1933].…”

Section: Discussionmentioning

confidence: 56%

Effects of Synthetic Oestrogens and Carcinogens When Administered to Rats by Subcutaneous Implantation of Crystals or Tablets

Noble¹

1939

Journal of Endocrinology

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“…It may be difficult to correlate this BPAeffect with the known estrogenic property of this compound [12][13][14], since BPA had almost no effect on the seminal vesicle. Estrogens have been known to stimulate the development of the fibrous tissue and muscular walls of both prostate and seminal vesicle [20], without stimulating the epithelium and secretory activity [33]. Moreover, it seems very improbable, that the increase of the immunoreactive AR in the prostatic epithelial cells (not in the seminal vesicle) is up-regulated by estrogens.…”

Section: Influence Of Bpamentioning

confidence: 99%

“…Although the Hershberger assay is a valid quantitative method for evaluating androgenic or anti-androgenic properties of substances by measuring the organ weight of seminal vesicles and prostates, the findings obtained by this assay provide only limited information on the specificity of the observed effects when only the reactions of the organ weights are judged: For example, the growth of seminal vesicles can be stimulated not only by androgens but also by estrogenic substances, well known as a paradoxical effect of estrogens [18][19][20].…”

Section: Hershberger Assaymentioning

confidence: 99%

The xenoestrogen bisphenol A in the Hershberger assay: Androgen receptor regulation and morphometrical reactions indicate no major effects

Nishino

Wedel²,

Schmitt

et al. 2006

The Journal of Steroid Biochemistry and Molecular Biology

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“…Both prostate and seminal vesicles show marked decrease in size due to loss of secretion after 14 days, and the maximum amount of shrinkage has generally occurred after 30 days. Although oestrone is known to have a direct action on rudimentary or atrophie rat seminal vesicles, [Freud, 1933] where it stimulates fibrosis and causes a slight enlargement, it is doubtful if it has a significant effect on size in this series. The testes vary greatly in weight (0-59-2-8 g.) after about a month, but all show degenerative changes in the interstitial cells and disorganization of the germinal epithelium in many of the tubules, although spermatozoa may still be present in others.…”

Section: Materials and Techniguementioning

confidence: 98%

Depression of Hypophyseal Activity by the Implantation of Tablets of Oestrone and Oestradiol

Deanesly¹

1939

Journal of Endocrinology

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Conditions of hypertrophy of the seminal vesicles in rats

Cited by 57 publications

References 1 publication

Effects of Synthetic Oestrogens and Carcinogens When Administered to Rats by Subcutaneous Implantation of Crystals or Tablets

Effects of Synthetic Oestrogens and Carcinogens When Administered to Rats by Subcutaneous Implantation of Crystals or Tablets

The xenoestrogen bisphenol A in the Hershberger assay: Androgen receptor regulation and morphometrical reactions indicate no major effects

Depression of Hypophyseal Activity by the Implantation of Tablets of Oestrone and Oestradiol

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