Depression of Hypophyseal Activity by the Implantation of Tablets of Oestrone and Oestradiol

Use of Oestrogenized Male Rats for the Study of Gonadotrophic Activity

“…In rats of 100-140 g. body-weight the seminal vesicles, still comparatively small at the beginning of the experiment, were reduced to about 50 mg. after 5 or 6 days' oestrogenization. The testes, as already found [Deanesly, 1939], showed a progressive reduction in size and dis¬ organization and disappearance of the germinal epithelium during the 20-day experiments. It is clear that stilboestrol in tablet form exercises an immediate effect in suppressing the gonadotrophic secretion of the pituitary gland.…”

“…A review of the literature has recently been given by Deanesly [1939]. Injection of growth hormone and gonadotrophins during the course of oestrogen treatment will maintain growth and prevent the atrophy of the reproductive organs [Spencer, D'Amour & Gustavson, 1932; Moore & Price, 1932].…”

Absorption of Implanted Solid Drug

“…Physiological Need of the Animal.-Neither physiological need for the implanted substance nor the animal's sex seems to affect the absorption rates of implants (14,33,34,38,40,42,47,(59)(60)(61)(62)(63)(64)(65)(66). These experiments and observations lend support to the view that absorption rate is solution rate limited in the usual case.…”