Conditions of the Reproductive Organs

Romm, Aviva; Burgess, Isla; Winston, David; Zick, Suzanna M.; Crawford, Amanda McQuade

doi:10.1016/b978-0-443-07277-2.00009-x

Cited by 5 publications

(14 citation statements)

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“…An increase in the number of inflammatory cells and the production of inflammatory cytokines, can cause pelvic inflammation owing to local and systemic responses of the immune system [30, 31]. Growth factors and inflammatory mediators secreted by peritoneal leukocytes are involved in the pathogenesis of the disease through an increase in the number of endometrial cells at ectopic sites, whereas a large number of inflammatory cells and mediators, such as proteolytic enzymes, peritoneal macrophages, complement fragments, prostaglandins (PG), IL-1, and tumor necrosis factor (TNF), are produced in the peritoneal fluid of patients suffering from the disease [32].…”

Section: Etiology and Pathogenesis Of Endometriosismentioning

confidence: 99%

“…Antispasmodics and anti-inflammatory agents, for instance, wild yam, viburnum, ginger, and chamomile, can be used to treat uterine, intestinal, bowel, and urinary pain and irritability; the pain of endometriosis originates from the irritation of endometrial tissue outside of its normal site in the uterus. Sedatives are active when deep rest or sleep provides relief from pain [32, 115].…”

Section: Importance Of Medicinal Plants Used In Folk Medicine To Treamentioning

confidence: 99%

“…(Asteraceae), Echinacea sp., Galium aparine L. (Rubiaceae), and Phytolacca sp. (Phytolaccaceae), are frequently used to treat endometriosis [32, 115].…”

Section: Importance Of Medicinal Plants Used In Folk Medicine To Treamentioning

confidence: 99%

“…Centella asiatica (L.) Urban “gotu kola,” is used for its anti-inflammatory and antimicrobial properties. It is considered in the cases of endometriosis, combined with other herbs, for complete treatment or to help in recovery after the surgery [32, 122].…”

Section: Experimental Studies On Medicinal Plants Against Endometriosismentioning

confidence: 99%

“…is used as an antioxidant. It stimulates the immune system, enhances the production of phagocytes, cytokines, and immunoglobins, and reduces inflammation in women with endometriosis (Table 1 ) [32, 126].…”

Section: Experimental Studies On Medicinal Plants Against Endometriosismentioning

confidence: 99%

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Novel Drug Targets with Traditional Herbal Medicines for Overcoming Endometriosis

İlhan

Dereli

Akkol

2019

CDD

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Endometriosis is a disease in which the lining of the endometrium is found outside of the uterus. Recent medical treatments for endometriosis have adverse effects, limiting their long-term use. Furthermore, the recurrence of the disease after the cessation of therapy is quite common, and most patients need to continue treatment to maintain a hypoestrogenic environment till conception. Notwithstanding recent advances in computational and chemical practices, traditional medicines are considered the most consistent sources for the discovery of new drugs. Numerous medicinal plants and plantderived compounds have been tested against gynecological disorders, mainly endometriosis. This review aimed to describe the pharmacological activity profile of the medicinal plants and their active ingredients and draw attention to the discovery of multitargeted drug molecules for rational therapy.

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Section: Etiology and Pathogenesis Of Endometriosismentioning

confidence: 99%

Section: Importance Of Medicinal Plants Used In Folk Medicine To Treamentioning

confidence: 99%

“…(Asteraceae), Echinacea sp., Galium aparine L. (Rubiaceae), and Phytolacca sp. (Phytolaccaceae), are frequently used to treat endometriosis [32, 115].…”

Section: Importance Of Medicinal Plants Used In Folk Medicine To Treamentioning

confidence: 99%

Section: Experimental Studies On Medicinal Plants Against Endometriosismentioning

confidence: 99%

Section: Experimental Studies On Medicinal Plants Against Endometriosismentioning

confidence: 99%

See 3 more Smart Citations

Novel Drug Targets with Traditional Herbal Medicines for Overcoming Endometriosis

İlhan

Dereli

Akkol

2019

CDD

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Food Enzymes in Pharmaceutical Industry: Perspectives and Limitations

Ahmad

Tabassum

Ahmad

et al. 2018

Enzymes in Food Technology

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Tetrasiklin Antibiyotikleri ve Bromelain Enzimi Arasındaki Etkileşimlerin Kenetleme Araçları Kullanılarak İncelenmesi

AYLAZ

2023

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Bromelain, extracted from the stem of the pineapple, is a complex enzyme used for different purposes. Bromelain supplements are often used to facilitate digestion, improve the circulatory system and relieve arthritis symptoms due to its pain relief. However, in some cases where there is a risk of antibiotic use or bleeding, the use of bromelain or direct consumption of pineapple should be limited. For this purpose, this study was carried out to show the mechanism by which the antibiotic bromelain interaction occurs. Firstly, the bromelain molecule and demeclocycline, minocycline, and tetracycline antibiotics were prepared in the UCSF Chimera visualizing program. The interactions were monitored in the Auto Dock Molecular Modelling Toolkit molecular modeling program. The free binding energies of these interactions were also calculated in Auto Dock. According the molecular modelling results, bromelain and demeclocycline, minocycline, tetracycline antibiotics were interact with hydrogen bonds and hydrophobic interactions. These interactions between bromelain and antibiotics were energetically favorable based on free binding energy calculations.

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Conditions of the Reproductive Organs

Cited by 5 publications

References 0 publications

Novel Drug Targets with Traditional Herbal Medicines for Overcoming Endometriosis

Novel Drug Targets with Traditional Herbal Medicines for Overcoming Endometriosis

Food Enzymes in Pharmaceutical Industry: Perspectives and Limitations

Tetrasiklin Antibiyotikleri ve Bromelain Enzimi Arasındaki Etkileşimlerin Kenetleme Araçları Kullanılarak İncelenmesi

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