Conductimetric determination of phenylpropanolamine HCl, ranitidine HCl, hyoscyamine HBr and betaine HCl in their pure state and pharmaceutical preparations

Issa, Y. M.; Youssef, Ashraf; Mutair, Ali A.

doi:10.1016/j.farmac.2005.03.002

Cited by 18 publications

(10 citation statements)

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“…In these cases, the titration curve could be represented by two intersecting lines at the end point. The conductometric technique was used for the determination of many drugs [33,36,39] on using MPA as a titrant; the ion-associates are formed between the studied drugs and MPA as shown in the following equation:…”

Section: Resultsmentioning

confidence: 99%

“…The titrant was used for quantitative determination of some pharmaceutical compounds applying conductometric, spectrophotometric and potentiometric procedure [33][34][35]. The sharpness of the endpoint is greatly dependent on the solubility of the formed ion-pairs [36]; the conductance data were employed to calculate the solubility products of the considered precipitation reaction. The endpoint was established via an experiential graphical process where the intersection of two straight lines represents the equivalence point.…”

Section: Introductionmentioning

confidence: 99%

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Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid

et al. 2013

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KEYWORDSConductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl with molybdophosphoric acid as a precipitating reagent was investigated. Various experimental conditions were evaluated and results obtained showed good recoveries, (mean recovery values of 100.51, 99.68, 99.41 and relative standard deviation of 0.332, 0.404, 0.509 for sibutramine HCl, sumatriptan succinate and lomefloxacine HCl, respectively). Numerical derivatization (first and second derivative) of the data was also applied, showing more accurate results compared to classical ones. The described procedures allowed the determination of equilibrium constants those indicated high degree of completeness of the precipitation reaction. Other parameters related to ion pair complex such as solubility and solubility product were also calculated. The described procedures allowed the determination of the studied drugs in the range of 5-15 mg. The precipitate obtained by ion pairing of lomefloxacine HCl with molybdophosphoric acid was spectroscopically characterized using IR. The method was further applied successively to pharmaceutical formulations, the proposed method offering a high degree of accuracy and precision when compared to reference methods.Sibutramine HCl Solubility product Lomefloxacine HCl Sumatriptan succinate Molybdophosphoric acid Conductometric determination

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid

et al. 2013

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“…In order to assure the quality of R . HCl containing pharmaceutical formulations, several methods have been developed for its determination, including high-performance liquid chromatography (HPLC) [1][2][3][4][5][6] , high-performance thin-layer chromatography and scanning densitometry 7 , differential pulse polarography 8 , amperometry 9 , capillary electrophoresis 10 , conductometry 11 , coulometry 12 , voltammetry 13 , potentiometry 14 , fluorimetry 15 , chemiluminescence 16 , AAS 17 . The official method described in the United States Pharmacopeia 18 is based on potentiometric titration of R .…”

Section: Ranitidine N-(2-{[(5-dimethylamino)methyl]-2-furanyl}-methymentioning

confidence: 99%

Spectrophotometric Method for Ranitidine Determination in Drugs Using Rhodamine B

Moldovan¹,

Aboul‐Enein²

2012

J. Chil. Chem. Soc.

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A new spectrophotometric method has been developed for the determination of ranitidine hydrochloride (R . HCl) in bulk drug and in tablet formulation. The proposed method involves the addition of a measured excess of bromate-bromide reagent in hydrochloric acid medium to R . HCl, followed by determination of residual bromine by reacting with a fixed amount of Rhodamine B (RB) and measuring the absorbance at λ max =557 nm. Beer's law was found in the range of 0.3-3.2 μg ml -1 of R . HCl, with a good correlation coefficient (r=0.9997). The limits of detection and quantification were calculated to be 0.08 μg ml -1 and 0.24mg ml -1 , respectively. The different experimental parameters affecting the development and stability of the proposed method were carefully studied and optimized. The validity of the proposed method tested by analyzing the pure and pharmaceutical formulations and compared well with those obtained by the official method, demonstrated good accuracy and precision.

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“…spectrophotometry,[10][11][12] MS,13 NMR14,15 and titration methods [16][17][18]. Potentiometric methods with ion selective electrodes (ISE's) can provide valuable and straightforward means of assaying drugs in complex mixtures, as they make possible the direct (°) Corresponding author; Fax: +20-2-5728843; E-mail address: ayoussef@chem-sci.cu.edu.eg ; hmdyssf@yahoo.com…”

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Potentiometric Batch and Flow Injection Analysis of Betaine Hydrochloride

2007

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Novel PVC membrane electrodes for the determination of betaine ion based on the formation of betaine-tetraphenylborate (Be-TPB) and betaine-phosphotungstate (Be-PT) ion-exchangers as electroactive materials are described. The sensors show a fast, stable, near Nernstian response for 6.92 x 10(-6) to 7.94 x 10(-3) M and 1.0 x 10(-4) to 1.0 x 10(-2) M betaine hydrochloride (Be.Cl) in case of Be-TPB electrode applying batch and flow injection analysis (FIA), respectively, and 2.95 x 10(-5) to 2.26 x 10(-3) M and 3.16 x 10(-5) to 1.0 x 10(-2) M in case of Be-PT electrode for batch and FIA electrodes, respectively, at 25 degrees C over the pH range of 3.5-10 with a cationic slope of 60.2 and 59.1 mV decade(-1) and a fast potential response of < or =15 s. The lower detection limits are 7.94 x 10(-6) and 3.18 x 10(-5) M Be.Cl for Be-TPB and Be-PT electrodes, respectively. Selectivity coefficient data for some common inorganic cations, sugars, amino acids and the components other than betaine, of the mixed drug investigated show negligible interference. The electrodes have been applied to the direct potentiometric determination of betaine hydrochloride in water and in a pharmaceutical preparation under batch and FIA conditions. Potentiometric titrations of Be.Cl with NaTPB and PTA as titrants were monitored with the developed betaine electrodes as an end point indicator electrode. The determination of Be.Cl shows an average recovery of 100.8% with mean relative standard deviation of 0.61%. The effect of temperature on the electrodes was also studied.

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Conductimetric determination of phenylpropanolamine HCl, ranitidine HCl, hyoscyamine HBr and betaine HCl in their pure state and pharmaceutical preparations

Cited by 18 publications

References 18 publications

Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid

Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid

Spectrophotometric Method for Ranitidine Determination in Drugs Using Rhodamine B

Potentiometric Batch and Flow Injection Analysis of Betaine Hydrochloride

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