Conductimetric determination of reproterol HCl and pipazethate HCl and salbutamol sulphate in their pharmaceutical formulations

Issa, Y. M.; Shoukry, A; El‐Nashar, Rasha M.

doi:10.1016/s0731-7085(01)00415-0

Cited by 33 publications

(19 citation statements)

References 14 publications

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“…This divergence from linearity can be attributed to the formation of an ion-associate, presumably, by replacing the drug cation (lomeH + ) with the highly mobile H + ions, so the conductivity increases. After the endpoint, more acid reagent is added and the conductivity changes more rapidly [33,40]. Titration curves (Figure 1) had weak curvature around end point that may affect its value.…”

Section: Resultsmentioning

confidence: 99%

Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid

et al. 2013

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KEYWORDSConductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl with molybdophosphoric acid as a precipitating reagent was investigated. Various experimental conditions were evaluated and results obtained showed good recoveries, (mean recovery values of 100.51, 99.68, 99.41 and relative standard deviation of 0.332, 0.404, 0.509 for sibutramine HCl, sumatriptan succinate and lomefloxacine HCl, respectively). Numerical derivatization (first and second derivative) of the data was also applied, showing more accurate results compared to classical ones. The described procedures allowed the determination of equilibrium constants those indicated high degree of completeness of the precipitation reaction. Other parameters related to ion pair complex such as solubility and solubility product were also calculated. The described procedures allowed the determination of the studied drugs in the range of 5-15 mg. The precipitate obtained by ion pairing of lomefloxacine HCl with molybdophosphoric acid was spectroscopically characterized using IR. The method was further applied successively to pharmaceutical formulations, the proposed method offering a high degree of accuracy and precision when compared to reference methods.Sibutramine HCl Solubility product Lomefloxacine HCl Sumatriptan succinate Molybdophosphoric acid Conductometric determination

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Section: Resultsmentioning

confidence: 99%

Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid

et al. 2013

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“…NaTPB is a well known complexing agent that commonly used in potentiometric [10] and conductimetric [11] determination of pharmaceutical raw materials and it was found that NaTPB is soluble in acetonitrile and reacts in it with Di-HCl to form soluble complex which has a characteristic DPV. It was found that the I p of the formed complex increases and that of Di-HCl decrease with the addition of NaTPB.…”

Section: Complexation With Natpbmentioning

confidence: 99%

“…6, 7), the sudden change in the slope after the end point is may be related to the formation of RNH x + and OH -by hydrolysis. On adding NaTPB, the ion pair formed replaces RNHx + ions by mobile Na + and the conductivity increases [11]. After the end point, more reagent is added and the conductivity increase more rapidly.…”

Section: Determination Of Di-hcl In Raw Materials and Pharmaceutical Fmentioning

confidence: 99%

Differential Pulse Voltammetric and Conductimetric Determination of Diphenylpyraline HCl in Raw Material and Pharmaceutical Preparation

Abdel‐Ghani¹,

Hussein²

2009

TOELECJ

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Diphenylpyraline hydrochloride (Di-HCl) has been determined in raw material and its pharmaceutical preparation Eskornade capsule (5mg/capsule) using differential pulse voltammetry (DPV) and conductimetric determination. It was found that Di-HCl gives a characteristic cyclic voltammetric (CV) and differential pulse voltammetric (DPV) peak in acetonitrile using platinum and glassy carbon sensors as working electrodes. The peak current (Ip) of the DPV peak increases linearly within the concentration range 4.5 x 10 -4 -1x10 -2 mol/L of the investigated drug. The concentration of DiHCl in raw drug material and in its pharmaceutical preparations was determined using standard addition method, RandlesSevcik equation and indirectly via its complexation with sodium tetra phenylborate (NaTPB), the obtained average recoveries were 101.44 and 100.49 with standard deviation (SD) 0.45 and 0.38 (n = 4) for platinum and glassy carbon electrodes respectively. The effect of scan rate, sample concentration and supporting electrolyte on the peak current (I p ) and peak potential (E p ) was investigated.In addition a simple and sensitive conductimetric method was used for determination of Di-HCl based on its ion association with sodium tetraphenylborate (NaTPB). The effect of solvent, reagent concentration, temperature and molar ratio was studied. The obtained average recovery was 101.44 with SD 0.45 (n = 4).

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“…Conductimetric measurements were carried out as previously described method 19 with the aid of an Engineered Systems & Designs [ESD] conductometer model 72 (Conductance/TDS) (USA) provided with conductivity cell of 1.000 cell constant.…”

Section: Potentiometric Studies and Electrochemical Systemmentioning

confidence: 99%

“…based on the sterospecificity and electrostatic environment. 19 The inorganic cations do not interfere because of differences in ionic size, mobility and permeability. Also, the smaller the energy of hydration of the cation, the greater is the response of the membrane.…”

Section: Selectivity Of the Electrodementioning

confidence: 99%

Flow Injection Analysis with Tubular Membrane Ion‐Selective Electrode and Coated Wires for Buspirone Hydrochloride

et al. 2006

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Summary -New Plastic membrane ion-selective electrode for buspirone hydrochloride based on buspironium tetraphenylborate was prepared. The electrode exhibited mean slope of calibration graph of 58.4 mV per decade of BusCl concentration at 25°C. The electrode can be used within the concentration range 6.3 x10 -5 -10 -2 M BusCl at a pH range of 2.5-7.0. The standard electrode potentials were determined at different temperatures and used to calculate the isothermal temperature coefficient of the electrode, amounting to 0.00056 V°C -1 . The electrode showed a very good selectivity for BusCl with respect to a number of inorganic cations, sugars and amino acids. The electrode was applied to the potentiometric determination of the buspirone ion and its pharmaceutical preparation under batch and flow injection conditions. Also, buspirone was determined by conductimetric titrations. Graphite rod, copper and silver coated wire electrodes were prepared and characterized as sensors for the drug under investigation.

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Conductimetric determination of reproterol HCl and pipazethate HCl and salbutamol sulphate in their pharmaceutical formulations

Cited by 33 publications

References 14 publications

Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid

Conductometric determination of sibutramine HCl, sumatriptan succinate and lomefloxacine HCl and the solubility products of their ion associates with molybdophosphoric acid

Differential Pulse Voltammetric and Conductimetric Determination of Diphenylpyraline HCl in Raw Material and Pharmaceutical Preparation

Flow Injection Analysis with Tubular Membrane Ion‐Selective Electrode and Coated Wires for Buspirone Hydrochloride

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