Conducting‐Polymer Nanotubes for Controlled Drug Release

Abidian, Mohammad Reza; Kim, Dong Hwan; Martin, David C.

doi:10.1002/adma.200501726

Cited by 826 publications

(594 citation statements)

References 31 publications

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“…Nanostructured hydrogels could potentially be used as templates to synthesize CP-hydrogels with specific structures (category A, figure 3). As an illustration of this approach using a degradable polymer rather than a hydrogel, Abidian et al [3,4,7,25,118] electrodeposited 100 to 600 nm diameter CP nanofibrils by using electrospun poly(L-lactic acid) (PLLA) and poly(lactic-co-glycolic acid) (PLGA) nanofibres as a template. Either PEDOT or PPy was directly electrodeposited on the gold neural probe coated with the electrospun polymers.…”

Section: Routes For Producing Cp-hydrogelsmentioning

confidence: 99%

“…This is thought to be predominantly due to thicker films being grown through the hydrogel, supported by the decrease in impedance correlating with increased CP polymerization time. Other CP-polymer networks designed for increased surface area, such as those comprised of electrospun hydrogels or CP nanotubes, have decreased impedance mediated through the increased charge transfer area [3,25]. Abidian et al have fabricated PEDOT nanotubes, produced by CP coating PLLA/PLGA nanofibres and have reported a reduction in electrode impedance from 4 M for bare gold, to 1 k for the nanofibres [25].…”

Section: Electrical Characterizationmentioning

confidence: 99%

“…Thus CPs alone may not be sufficient to create a long-term stable interface between synthetic implant devices and neural tissue. More recently, design and development of CP-hydrogel blends have been proposed as an approach to overcoming some of the limitations that CPs used alone may present [3,[25][26][27][28]. The underlying premise of this approach is that hydrogels may act to modulate and improve mechanical properties, as well as provide a low-fouling surface and a depot for water soluble, bioactive agents.…”

Section: Introductionmentioning

confidence: 99%

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Conducting polymer-hydrogels for medical electrode applications

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et al. 2010

Science and Technology of Advanced Materials

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Conducting polymers hold significant promise as electrode coatings; however, they are characterized by inherently poor mechanical properties. Blending or producing layered conducting polymers with other polymer forms, such as hydrogels, has been proposed as an approach to improving these properties. There are many challenges to producing hybrid polymers incorporating conducting polymers and hydrogels, including the fabrication of structures based on two such dissimilar materials and evaluation of the properties of the resulting structures. Although both fabrication and evaluation of structure-property relationships remain challenges, materials comprised of conducting polymers and hydrogels are promising for the next generation of bioactive electrode coatings.

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Section: Routes For Producing Cp-hydrogelsmentioning

confidence: 99%

Section: Electrical Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Conducting polymer-hydrogels for medical electrode applications

Green

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Poole-Warren

et al. 2010

Science and Technology of Advanced Materials

246

182

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“…addressable delivery systems for charged biomolecules. We envisage that such ionic circuits will have impact in various fields including sensors 25 , lab-on-a-chip 26 , drug delivery 27 and electrochemical components 28 .…”

mentioning

confidence: 99%

Toward Complementary Ionic Circuits: The npn Ion Bipolar Junction Transistor

2011

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Many biomolecules are charged and may therefore be transported with ionic currents. As a step toward addressable ionic delivery circuits, we report on the development of a npn ion bipolar junction transistor (npn-IBJT) as an active control element of anionic currents in general, and specifically, demonstrate actively modulated delivery of the neurotransmitter glutamic acid. The functional materials of this transistor are ion exchange layers and conjugated polymers. The npn-IBJT shows stable transistor characteristics over extensive time of operation and ion current switch times below 10 s. Our results promise complementary chemical circuits similar to the electronic equivalence, which has proven invaluable in conventional electronic applications.

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“…Although these nanotubes were initially applied in electronic devices (Xiao et al 2007), they also have significant potential in biomedical applications. A recent study by D. C. Martin and colleagues developed conductive nanotubes, which can be electrically stimulated for a controlled release of drugs (Abidian et al 2006). For this purpose, they generated PEDOT nanotubes with biodegradable poly(lactide-coglycolide) (PLGA) fiber cores loaded with dexamethasone.…”

Section: Nanomaterials Scaffolds For Neuroregenerationmentioning

confidence: 99%

Novel Nanomaterials for Clinical Neuroscience

Gilmore

Xiang

Quan

et al. 2008

J Neuroimmune Pharmacol

213

123

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Neurodegenerative disorders including Alzheimer's and Parkinson's diseases, amyotrophic lateral sclerosis, and stroke are rapidly increasing as population ages. The field of nanomedicine is rapidly expanding and promises revolutionary advances to the diagnosis and treatment of devastating human diseases. This paper provides an overview of novel nanomaterials that have potential to improve diagnosis and therapy of neurodegenerative disorders. Examples include liposomes, nanoparticles, polymeric micelles, block ionomer complexes, nanogels, and dendrimers that have been tested clinically or in experimental models for delivery of drugs, genes, and imaging agents. More recently discovered nanotubes and nanofibers are evaluated as promising scaffolds for neuroregeneration. Novel experimental neuroprotective strategies also include nanomaterials, such as fullerenes, which have antioxidant properties to eliminate reactive oxygen species in the brain to mitigate oxidative stress. Novel technologies to enable these materials to cross the blood brain barrier will allow efficient systemic delivery of therapeutic and diagnostic agents to the brain. Furthermore, by combining such nanomaterials with cell-based delivery strategies, the outcomes of neurodegenerative disorders can be greatly improved.

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Conducting‐Polymer Nanotubes for Controlled Drug Release

Cited by 826 publications

References 31 publications

Conducting polymer-hydrogels for medical electrode applications

Conducting polymer-hydrogels for medical electrode applications

Toward Complementary Ionic Circuits: The npn Ion Bipolar Junction Transistor

Novel Nanomaterials for Clinical Neuroscience

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