Conductive Adhesive and Antibacterial Zwitterionic Hydrogel Dressing for Therapy of Full-Thickness Skin Wounds

Abstract

Any sort of wound injury leads to the destruction of skin integrity and wound formation, causing millions of deaths every year and accounting for 10% of death rate insight into various diseases. The ideal biological wound dressings are expected to possess extraordinary mechanical characterization, cytocompatibility, adhesive properties, antibacterial properties, and conductivity of endogenous electric current to enhance the wound healing process. Recent studies have demonstrated that biomedical hydrogels can be used as typical wound dressings to accelerate the whole healing process due to them having a similar composition structure to skin, but they are also limited by ideal biocompatibility and stable mechanical properties. To extend the number of practical candidates in the field of wound healing, we designed a new structural zwitterion poly[3-(dimethyl(4-vinylbenzyl) ammonium) propyl sulfonate] (SVBA) into a poly-acrylamide network, with remarkable mechanical properties, stable rheological property, effective antibacterial properties, strong adsorption, high penetrability, and good electroactive properties. Both in vivo and in vitro evidence indicates biocompatibility, and strong healing efficiency, indicating that poly (AAm-co-SVBA) (PAS) hydrogels as new wound healing candidates with biomedical applications.

Formulation and Optimal Design of Dioscorea bulbifera and Honey-Loaded Gantrez®/Xyloglucan Hydrogel as Wound Healing Patches

“…This led to a slight change in the dimension and the weight of the hydrogels. The size of the hydrogel patches was 3.05 × 3.22 × 1.08 cm 3 after water absorption, whereas the size was 3.02 × 3.18 × 1.04 cm 3 and 3.01 × 3.16 × 1.02 cm 3 , respectively, for the hydrogels absorbed with honey and the honey/extract mixture. The weight of the hydrogels increased by 792.11% ± 9.49% after immersion in the water, while the weight change of the hydrogels was 778.38% ± 7.15% and 754.05% ± 5.41% after immersion in honey and the D. bulbifera extract/honey mixture.…”

“…Several properties of hydrogels represent ideal dressings, such as hydrogel dressings could absorb wound exudate and preserve a moist environment of the wound area [1]. Nowadays, abundant hydrogel dressings are designed with the ideal dressing properties, for instance, cationic peptide-based salt-responsive antibacterial hydrogel dressings [2] and poly [3-(dimethyl(4-vinylbenzyl) ammonium) propyl sulfonate] (SVBA) in poly-acrylamide network hydrogel dressings (poly(AAm-co-SVBA) [3].…”

Conductive hydrogels for tissue repair

“… 114 Another zwitterion poly[3-(dimethyl(4-vinylbenzyl) ammonium) propyl sulfonate] (SVBA) was also introduced into a poly-acrylamide network, to prepare a conductive dressing with effective antibacterial properties, strong adsorption, high permeability and good electrical activity. 115 …”

Progress in Antibacterial Hydrogel Dressing

“…Wang et al designed and introduced a novel structure of amphoteric ionic poly[3-(dimethyl (4-vinyl benzyl) ammonium) propyl sulfonate] (SVBA) into the polyAAm network to obtain a novel salt-responsive conductive hydrogel. Due to the addition of SVBA, PAS-2 hydrogel has good electrical activity and significant mechanical properties, as well as good cellular compatibility, stable rheological properties, effective antibacterial properties, strong adsorption, and high permeability, which can effectively promote wound healing and can be used as a medical dressing [ 165 ]. Dai et al developed zwitterionic sulfobetaine acrylamide antibacterial hydrogel combined with laponite (LAP) nanoplatelets and methyl acrylamide dopamine (DMA) for wound dressings.…”