Conductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation

Cantu, Travis; Walsh, Kyle; Pattani, Varun P.; Moy, Austin J.; Tunnell, James W.; Irvin, Jennifer A.; Betancourt, Tania

doi:10.2147/ijn.s116583

Cited by 40 publications

(36 citation statements)

References 36 publications

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“…7,8 However, most of the QDs that are effectively used as contrast imaging agents are toxic inorganic nanoparticles, which raises serious concerns regarding their potential long-term cytotoxicity under in vivo conditions. [9][10][11][12] Hence, the quest for alternative biocompatible as well as non-cytotoxic materials has gained momentum. 13,14 Several near infrared (NIR) light-emitting polymers such as polyuorenes (PFs), 15 polyethylene-dioxythiophene (PEDOT), 16 polypyrrole (PPy) 17 etc.…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted facile synthesis of poly(luminol-co-phenylenediamine) copolymers and their potential application in biomedical imaging

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Microwave-assisted facile synthesis of poly(luminol-co-phenylenediamine) copolymers and their potential application in biomedical imaging

et al. 2018

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“…Conductive polymers, with polypyrrole as the typical example, have been proved to show remarkable photothermal conversion effect and therefore can be used for photothermal ablation of cancer (Yang et al, ; Zha, Yue, Ren, & Dai, ). Such conductive polymers also include some copolymers and multipolymers that can be engineered to present desired photothermal properties (Cantu et al, ; Cheng, Yang, Chen, & Liu, ; MacNeill, Coffin, Carroll, & Levi‐Polyachenko, ). Nanostructures of semiconductors such as chalcogenides (Li et al, ; Tian et al, ; Tian et al, ) also exhibit near infrared photothermal conversion properties and have attracted significant research attention.…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging and photothermal conversion properties of Gd‐C nanocomposites for interstitial lymphography

et al. 2019

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Dual‐functional agents for magnetic resonance imaging (MRI) guided photothermal therapy (PTT) of lymph cancer are highly desired. Signal enhancement, selectivity between lymphatic nodes/vessels and blood vessels, and photothermal conversion property are the criteria for such dual‐functional agent. In the current work, we demonstrated the potential of Gd‐C nanocomposites as dual‐functional agents for the MRI and PTT of lymph node cancer. Gd‐C nanocomposites were synthesized via a hydrothermal carbonization approach with gadolinium chloride as Gd source and citric acid (CA) as C source. The particle size of the nanocomposites ranges from 40 to 100 nm which is smaller than the intercellular space of lymphatic vessels but much larger than that of the blood vessels. The nanocomposites were successfully applied to the MRI of cervical lymph nodes of rabbits. The signal enhancement of the lymph nodes reached the maximum value of 434% at 10 min after injection, without displaying any blood vessel. The Gd‐C nanocomposites also exhibited strong photothermal conversion effect. Under the illumination of an 808 nm laser, the aqueous suspension containing 1.0 wt % Gd‐C nanocomposites gave a maximum temperature rise of 28.2 °C and a light utilization efficiency of 30.4%. The results indicate that Gd‐C nanocomposites have significant potential in MRI guided PTT of lymph cancer.

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“…Esse procedimento cirúrgico visa à retirada total da glândula mamária associada ou não à linfadenectomia axilar. Quando unidas, a mastectomia e a linfadenectomia aumentam a possibilidade do surgimento de complicações, como por exemplo: dor, linfedema, seroma, deiscência cicatricial e diminuição de amplitudes de movimento em membros superiores, impactando negativamente na funcionalidade do indivíduo [2][3][4][5] .…”

Section: Introductionunclassified

Fototerapia Pós-Mastectomia: uma Revisão Sistemática

Rocha¹,

Lemos

Ribeiro³

2019

Rev. Brasileira.De.Cancerologia

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Introdução: O câncer de mama, patologia mais comum entre as mulheres, promove lesão nas estruturas das células ductais e lobulares da mama, assim como no tecido mamário adjacente e sistema linfático. A mastectomia é o procedimento padrão para a retirada do nódulo maligno e áreas acometidas, no qual a cirurgia desenvolve complicações físicas e funcionais. A fototerapia é um dos recursos fisioterapêuticos utilizados para minimizar os problemas ocasionados, oferecendo uma melhora na qualidade de vida das mulheres mastectomizadas. Objetivo: Descrever os possíveis efeitos da fototerapia nas complicações físicas pós-mastectomia. Método: Realizouse uma revisão sistemática nas bases de dados PubMed, LILACS, PEDro, SciELO, Bandolier, EBSCO, Clinical Evidence, MEDLINE e Biblioteca Cochrane no período de 2008 a 2018. Resultados: Dos 87 artigos encontrados, apenas seis preencheram os critérios de inclusão, nota superior de 5/10 na Escala PEDro, sendo detalhados nesta revisão. A fototerapia promoveu diminuição da dor em ombro, diminuição do volume e circunferência do linfedema no membro superior, regulação do sistema linfático e imunológico. Conclusão: Conclui-se que a fototerapia aplicada nas complicações pós-mastectomia mostrou ser uma terapêutica segura em pacientes oncológicos, sugerindo melhora sobre os aspectos da funcionalidade do indivíduo e sua qualidade de vida.

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Conductive polymer-based nanoparticles for laser-mediated photothermal ablation of cancer: synthesis, characterization, and in vitro evaluation

Cited by 40 publications

References 36 publications

Microwave-assisted facile synthesis of poly(luminol-co-phenylenediamine) copolymers and their potential application in biomedical imaging

Microwave-assisted facile synthesis of poly(luminol-co-phenylenediamine) copolymers and their potential application in biomedical imaging

Magnetic resonance imaging and photothermal conversion properties of Gd‐C nanocomposites for interstitial lymphography

Fototerapia Pós-Mastectomia: uma Revisão Sistemática

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