Conductometric studies of certain salts of penicillin

Goyan, Frank M.

doi:10.1002/jps.3030380313

Cited by 5 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hauser, Phillips & others, 1949;McBain, Huff & Brady, 1949;Thakkar & Wilham, 1970), whereas others (e.g. Lund & Pedersen-Bjergaard, 1949;Goyan, 1949;Hocking, 1951;Few & Schulman, 1953), have not observed surface activity. Surface tension measurements were, therefore, made on solutions of penicillin G and ampicillin in triple-distilled water; 0.05, 0.10, 0.25 and 0.50% w/v solutions of the antibiotics were examined for surface activity using a Du Nouy Tensiometer (Cambridge Instruments Limited), but in no case was significant surface activity detected.…”

Section: Surface Tensionmentioning

confidence: 94%

The diffusion of penicillin G and ampicillin through phospholipid sols

Padfield

Kellaway

1975

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

The self-diffusion coefficients of penicillin G and ampicillin have been determined at 25" in water and in the presence of a swamping concentration of electrolyte. The antibiotics diffused through phospholipid dispersions at a reduced rate due to interaction with the lipid aggregates. Ampicillin diffused through the phosphatidylcholine and phosphatidylethanolamine dispersions more rapidly than penicillin G, whereas the latter diffused more rapidly through the lysophosphatidylcholine dispersions. Estimates of binding have been made from these data and compared with those obtained from equilibrium dialysis studies. Surface tension measurements indicated that the antibiotics exhibited minimal surface activity. These results have been correlated with data obtained in other studies and a possible explanation has been advanced for the reported differences in in vivo activity of penicillin G and ampicillin.

show abstract

Section: Surface Tensionmentioning

confidence: 94%

The diffusion of penicillin G and ampicillin through phospholipid sols

Padfield

Kellaway

1975

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…This view was supported by Vavruch , who claimed that the crystalline or amorphous penicillins behave mostly in aqueous solutions as colloidal electrolytes. On the other hand, Woodbury and Rosenblum, Kumler and Alpen, McBain et al, and Goyan, on the basis of conductivity experiments with sodium and potassium salts of penicillin G, concluded that no marked deviation from the behavior of completely dissociated electrolyte is observed. Canals et al took a somewhat in-between view.…”

Section: Introductionmentioning

confidence: 98%

Electrical Conductances of Dilute Aqueous Solutions of Sodium Penicillin G, Potassium Penicillin G, and Potassium Penicillin V in the 278.15−313.15 K Temperature Range

et al. 2007

View full text Add to dashboard Cite

Systematic determinations of electrical conductivities of sodium penicillin G, potassium penicillin G, and potassium penicillin V in the 278.15-313.15 K temperature range are reported. These conductivities are examined by applying the Quint-Viallard conductivity equations and the Debye-Hückel equations for activity coefficients. Determined dissociation constants and the limiting conductances of penicillin anions are based on the assumption that in dilute aqueous solutions, penicillin salts behave as acidic salts of dibasic acids, which are the final products of degradation reactions in acidic media.

show abstract

On the surface chemistry of sodium penicillin G

Few¹,

Schulman²

1953

Biochimica et Biophysica Acta

View full text Add to dashboard Cite

Conductometric studies of certain salts of penicillin

Cited by 5 publications

References 3 publications

The diffusion of penicillin G and ampicillin through phospholipid sols

The diffusion of penicillin G and ampicillin through phospholipid sols

Electrical Conductances of Dilute Aqueous Solutions of Sodium Penicillin G, Potassium Penicillin G, and Potassium Penicillin V in the 278.15−313.15 K Temperature Range

On the surface chemistry of sodium penicillin G

Contact Info

Product

Resources

About