Condyloma Acuminata in Children

The authors present a study of five cases of vulvar congenital papillomas and papillomatoses in stillborns and neonates dead upon birth. The studied material was collected from five necropsies. The histopathological evaluation showed hyperkeratosis, acanthosis, papillomatosis, perinuclear haloes, and nuclear abnormalities. In three of the cases, the electron microscopy identified nuclear and cytoplasmatic viral particles ranging from 40 to 60 nm in size, compatible with HPV. The immunohistochemical study of those lesions showed nuclear and cytoplasmatic positivity. The authors concluded that the presence of viral particles suggestive of HPV added to the immunopositivity indicated the possibility of viral infection.

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“…The lesions identified months after birth, reported by some authors (5,15,16), can be the expression of an intra-uterine infection.…”

Section: Optical Microscopymentioning

confidence: 85%

“…The appearance of anogenital papillomas in children is not frequent. Since 1982, only 34 cases of infant condyloma acuminata were published (5). The ways of transmission indicated were perinatal, family contact, and sexual abuse.…”

Section: Introduction Tmentioning

confidence: 99%

Congenital papillomas and papillomatoses associated with the Human Papilloma Virus (HPV): report on 5 cases

Dias

Barcelos²,

Fonseca³

et al. 1995

Sao Paulo Med. J.

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“…Characterized by an epidermotrophic effect, and epithelial overgrowth, HPV can be transmitted via several pathways: sexual contact, autoinoculation, or contact with infected materials. Its incubation period usually lasts 2 to 3 months, but can last for up to 20 months [2,8,9].…”

Section: Discussionmentioning

confidence: 99%

“…Although it has shown an increase in recent years, it remains an uncommon problem in children. Whenever it is found in children, sexual abuse must be investigated [8,9].…”

Section: Discussionmentioning

confidence: 99%

Buschke-Löwenstein tumor in childhood: a case report

Ambriz-González

Escobedo-Zavala

Mora

et al. 2005

Journal of Pediatric Surgery

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“…Apart from these cutaneous HPV lesions, HPV infections of the oral mucosa, and particularly those of the larynx, seem to be typical pediatric diseases as well. More recently, HPV infections have also been described in the nasal mucosa and genital tract of children (De long et al, 1982;Sundararaj et al, 1991;Handley et al, 1993a,b;Obalek et al, 1993;Alberico et al, 1995).…”

mentioning

confidence: 99%

Human Papillomavirus Infections in Children: the Potential Role of Maternal Transmission

Syrjänen¹,

Puranen

2000

Critical Reviews in Oral Biology & Medicine

219

213

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To date, more than 100 types of human papillomavirus (HPV) have been identified. In the past 20 years, there has been an increasing interest in HPVs because of their potential role in the pathogenesis of malignant tumors. HPV infections are known to affect predominantly adult, sexually active age groups, whereas skin warts, at various anatomic sites, are usually associated with younger individuals. The modes of viral transmission in children remain controversial, including perinatal transmission, auto-and hetero-inoculation, sexual abuse, and, possibly, indirect transmission via fomites. Recent studies on perinatal infection with HPV have been inconclusive. It is still unclear how frequently perinatal infection progresses to clinical lesions, whether genital, laryngeal, or oral. Conflicting reports have been published on the prevalence of HPV infections in children. The current consensus is, however, that newborn babies can be exposed to cervical HPV infection of the mother. The detection rate of HPV DNA in oral swabs of newborn babies varies from 4% to 87%. The concordance of HPV types detected in newborn babies and their mothers is in the range of 57% to 69%, indicating that the infants might acquire the HPV infection post-natally from a variety of sources. HPV antibodies have been detected in 10% to 57% of the children, and there is usually no correlation between seropositivity and the detection of HPV DNA in either the oral or the genital mucosa. There is also evidence that transmission in utero or post-natal acquisition is possible. The mode of in utero transmission remains unknown, but theoretically the virus could be acquired hematogenously, by semen at fertilization, or as an ascending infection in the mother. The understanding of viral transmission routes is important, particularly because several vaccination programs are being planned worldwide. The serologic response to HPV detected in different populations of young women or women at risk of cervical cancer might be due to genital infections, but the possibility that HPV infection has been acquired earlier in life through the oral mucosa or respiratory tract cannot be ruled out.

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Condyloma Acuminata in Children

Cited by 34 publications

References 0 publications

Congenital papillomas and papillomatoses associated with the Human Papilloma Virus (HPV): report on 5 cases

Congenital papillomas and papillomatoses associated with the Human Papilloma Virus (HPV): report on 5 cases

Buschke-Löwenstein tumor in childhood: a case report

Human Papillomavirus Infections in Children: the Potential Role of Maternal Transmission

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