Condylomata Acuminata in the Pediatric Population

This article describes the epidemiology of mucosal human papillomavirs (HPV) in adults and children, its mode of transmission and its associated diseases. Over 40 genotypes of HPV infect the epithelial lining of the anogenital tract and other mucosal areas of the body. HPV is the most common sexually transmitted infection globally, with high prevalences found in both females and males. The predominant route of transmission is via sexual contact, although mother-to-child transmission is also possible. HPV infection may exist asymptomatically or may induce the formation of benign or malignant tumours in the genital, oral or conjunctival mucosa. Although most infections clear spontaneously, those that persist result in substantial morbidity and invoke high costs associated with the treatment of clinically relevant lesions. Some 13–18 mucosal HPV types are considered to have high oncogenic potential. HPV is recognized unequivocally as the main causal factor for cervical cancer, and is further responsible for a substantial proportion of many other anogenital neoplasms and head and neck cancers. Infections with HPV types that have low oncogenic risk, such as HPV-6 and 11, are associated with benign lesions of the anogenital areas known as condylomata acuminata (genital warts), oral papillomas, conjunctival papillomas, as well as low-grade squamous intra-epithelial lesions of the cervix. Perinatally acquired HPV can also cause recurrent respiratory papillomatosis in infants and young children. The implementation of HPV vaccination therefore has the potential to prevent a substantial proportion of HPV-related disease in the future.

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“…is often a complex challenge. Boyd [144] has shown that at least 20% of anogenital warts in children occur because of perinatal transmission.…”

Section: Anogenitalmentioning

confidence: 99%

Epidemiology of Mucosal Human Papillomavirus Infection and Associated Diseases

Trottier

Burchell

2009

Public Health Genomics

130

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“…In the 80's, the number of publications concerning the condyloma acuminata in children grew significantly (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20).…”

Section: Introduction Tmentioning

confidence: 99%

Congenital papillomas and papillomatoses associated with the Human Papilloma Virus (HPV): report on 5 cases

Dias

Barcelos²,

Fonseca³

et al. 1995

Sao Paulo Med. J.

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The authors present a study of five cases of vulvar congenital papillomas and papillomatoses in stillborns and neonates dead upon birth. The studied material was collected from five necropsies. The histopathological evaluation showed hyperkeratosis, acanthosis, papillomatosis, perinuclear haloes, and nuclear abnormalities. In three of the cases, the electron microscopy identified nuclear and cytoplasmatic viral particles ranging from 40 to 60 nm in size, compatible with HPV. The immunohistochemical study of those lesions showed nuclear and cytoplasmatic positivity. The authors concluded that the presence of viral particles suggestive of HPV added to the immunopositivity indicated the possibility of viral infection.

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“…Vertikal bulaş gebelikle ilişkilidir ve çocuklarda görülen AGV'nin %20'sinden sorumlu tutulmuştur (19). Vertikal bulaş, yenidoğanın doğum kanalından inişi sırasında kontaminasyonla veya in utero hayatta virüsün membranlardan geçişi veya kan yoluyla transplesantal geçiş şeklinde meydana gelebilmektedir (6).…”

Section: Hpv'ni̇n Bulaş Yollariunclassified

Çocukluk Çağında Anogenıtal Verru ve Cinsel İstismar

Demirkıran¹,

Arslan²

2014

Bull Leg Med

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ÖZETÇocuklarda anogenital bölgede cinsel yolla bulaşan hastalıkların varlığı cinsel istismarın delilidir. Human papilloma virüs (HPV) yetişkinlerin %80 ini etkileyen, en sık görülen cinsel yolla geçen hastalık kabul edilmektedir. Bu virüsün oluşturduğu verrülerin çocuklarda görülmesi cinsel istismar kanısı oluşturmaktadır. Çalışmamızda anogonital verrü (AGV) ile ilgili literatür derlemesi yaparak AGV'li çocuk olgularına adli tıp yönünden yaklaşım önerilerini sunmayı amaçladık. Yapılan çalışmalara göre HPV'nin cinsel istismar dışında farklı bulaş yollarının olduğu bilimsel olarak saptanmıştır. Bu nedenle AGV'li çocuklara yaklaşımda cinsel istismar ön yargısının kırılması gerektiği kanaati oluşmuştur. Çocuklar ve aileler "cinsel istismar" psikolojisinden uzak tutulmalıdır. Bu olgulara multidisipliner yaklaşılarak bulaş yolu hakkında kanaat oluştuktan sonra adli olgu açısından değerlendirilmelidir.Anahtar kelimeler: Anogenital verrü, bulaş yolları, cinsel istismar, HPV ABSTRACTThe presence of sexually transmitted diseases at anogenital region of children is an evidence of sexually abuse. Human papilloma virus (HPV) which affects 80% of adults is considered to be the most common sexually transmitted disease. The warts which were formed in children secondary to HPV, may be an indicator of sexual abuse. Following a review of the literature about the children with anogenital warts (AGW), we aimed at sharing the suggestions for the approach in this group of patients, from the forensic point of view.It has also been proved scientifically that HPV may be transmitted in some other ways else than sexual abuse. Therefore in children with AGW, the prejudicied consideration as having formed secondary to sexual abuse should be broken. Children and their families must not be misinformed in order to avoid the psychological stress of having formed secondary to sexual abuse. These cases should be evaluated by a multidisciplinary approach and may only be considered as a forensic case after having a clear judgement about way of sexually transmission.

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Condylomata Acuminata in the Pediatric Population

Cited by 33 publications

References 61 publications

Epidemiology of Mucosal Human Papillomavirus Infection and Associated Diseases

Epidemiology of Mucosal Human Papillomavirus Infection and Associated Diseases

Congenital papillomas and papillomatoses associated with the Human Papilloma Virus (HPV): report on 5 cases

Çocukluk Çağında Anogenıtal Verru ve Cinsel İstismar

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