This book chapter offers a new perspective on vehicle testing methods, by using driving simulators, which can be employed starting from early phases where components are designed, up to the real manufacturing stage. Based on these driving simulators, capable to thorough replicate real driving conditions, it can be described as a complex scenario, and the vehicle components can be dynamized with data coming from it. Therefore, with the use of a Virtual Reality (VR) environment, buildings, traffic signs, road types, and vehicles are imitated, and inspired by the real world or the imagination, but conclusive for the tested components. Moreover, for more realistic tests, a human driver can immerse into VR, controlling the virtual vehicle and leading to more reliable results. Many types of simulators are mentioned, with a focus on a specific type that is capable to test the vehicle’s propulsion system and its driver assistance systems. In the end, a case study is exposed where different configurations, software, and hardware, are tested and several results are presented.