Configurational and Volumetric Changes of the Early Prenatal Human Cerebellar Dentate Nucleus

Hayaran, Archana; Wadhwa, Shashi; Bijlani, Veena

doi:10.1159/000147134

Cited by 6 publications

(7 citation statements)

References 5 publications

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“…At 34 weeks, the cells of the DM region had a greater density of spines than those in the VL 193 region. This corroborates our earlier findings in Nisslstained sections [13], where wc observed that not only do convolutions begin to appear first in the DM region, but also that cells in this region mature earlier than those in the VL region.…”

Section: Discussionsupporting

confidence: 92%

Cytoarchitectural Development of the Human Dentate Nucleus: A Golgi Study

Hayaran

Wadhwa²,

Bijlani³

1992

Dev Neurosci

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Golgi-stained sections of the human cerebellar dentate nucleus (DN) at various gestational ages were examined to study the dendritic proliferation and maturation of the DN neurons. Bipolar cells were seen at 14–15 weeks. By 19–20 weeks, three cell types were identifiable: bipolar, hemisphereic and pyriform. The cells of the dorsomedial region matured earlier than those of the ventrolateral region. In addition to the above cell types, multipolar and nuclear boundary cells were observable at 24–25 weeks. The five cell types persisted during subsequent development. At no stage of development was any neuronal organizational pattern apparent. A remarkable dendritic proliferation occurred at 27–28 weeks. Spines and filiform processes were seen at 34 weeks of intrauterine life.

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Section: Discussionsupporting

confidence: 92%

Cytoarchitectural Development of the Human Dentate Nucleus: A Golgi Study

Hayaran

Wadhwa²,

Bijlani³

1992

Dev Neurosci

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“…Primary gyri (arrow) and a short fissure (arrowhead) are observed. In humans, the DN can be recognized in the destined site of cerebellar white matter as early as 11-12 WG (Hayaran et al 1991;K. Yamaguchi, N. Goto, unpublished observations).…”

Section: Discussionmentioning

confidence: 91%

“…According to her results, only a short fissure running rostrocausally is formed in the smooth lateral surface even in adult monkeys. Few attempts, on the other hand, have been made for 3D reconstruction analyses in humans, to our knowledge (Owaki 1958;Hayaran et al 1991). Therefore, we have applied a computerized reconstruction technique, a kind of shaded surface rendering, to explore the exact 3D structure and its developmental changes.…”

Section: Discussionmentioning

confidence: 99%

“…Owaki stated that a first fissure appeared by 6 months in the frontodorsal part. Hayaran et al (1991), later, described the 3D morphology of the DN during 11-28 WG in 11 fetuses using a similar method to that of Owaki. They reported that gyri appeared first at 24-25 WG in the dorsomedial region.…”

Section: Discussionmentioning

confidence: 99%

“…Morphological development of the human DN has long been a matter of interest and there are actually some reports on this subject (Owaki 1958;Heidary and Tomasch 1969;Wadhwa et al 1985;Mihajlovic and Zecevic 1986;Gudovic et al 1987;Yamaguchi et al 1989;Hayaran et al 1991Hayaran et al , 1992aHayaran et al , 1992b. Recently further, immunohistochemical techniques have been applied for exploring the functional development of the DN in human fetuses (Hayaran et al 1993;Yachnis et al 1993;Yu et al 1996).…”

Section: Introductionmentioning

confidence: 99%

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Three-dimensional structure of the human cerebellar dentate nucleus: a computerized reconstruction study

Yamaguchi

Goto

1997

Anatomy and Embryology

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To explore the regional differences in neuronal cytoarchitecture of human dentate nucleus, we examined first the three-dimensional structure of this nucleus with a computerized reconstruction technique, after making serial sections of the brain in seven fetuses aged from 20 to 39 weeks of gestation (WG), an infant (1-month-old) and two adults (22- and 85-year-old). The surface was broadly smooth at 20-22 weeks, but primary gyri or fissures were noticed in the rostral half of the lateral surface, earliest in its dorsal region. A small cavity (the hilus nuclei dentati) was situated in the middle of the medial surface, with four distinct margins. A great progress in gyration was noted after 22 weeks: gyri were observed over the entire surface by 28-29 weeks. Gyri were thicker in the caudal half than the rostral half both in the lateral and the medial surfaces. At this stage, the rostral margin of the hilus was partially cut off and the hilus was elongated toward the rostral tip, but its relative size appeared to be grossly equal to that at 22 weeks. The hilus began to open wider and wider after 30 weeks. Subdivision of the human dentate nucleus into two different parts (the smaller microgyric rostral part and the larger macrogyric caudal part) was accomplished by 35 weeks. We have previously, using morphometric approaches, reported that a vulnerable (or critical) period may exist during 20-30 weeks in the fetal development of the dentate nucleus. It is possible that this special ten weeks of mid-gestation may be coincident with the time of extensive growth in gyration for this nucleus. It will be necessary to sample the neurons independently from at least two different parts, as described above, to design further microscopic studies on the regional differences or on other cytological investigations.

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Developing dentate nucleus in man: a qualitative and quantitative study

et al. 1992

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Histological and quantitative studies were carried out in dentate nucleus (DN) of 14 human fetuses of gestational ages ranging from 10 weeks to 28 weeks in Nissl stained sections. The dentate nucleus was already well delineated at 11 weeks, but the adult profile was attained only by 27-28 weeks. The magnocellular dorsomedial region and the parvocellular ventrolateral region became apparent at 17-18 weeks. The numerical density of neurons showed a steady decline with advancing gestational age. However, the absolute neuronal count until 19-20 weeks was 367.1 x 10(3) followed by a count of 249.5 x 10(3) at 22-23 weeks. The reduction in the count between the two periods was significant and coincided with cell death which was striking between 19 and 23 weeks. The glial cell population continued to increase with advancing gestational age. The occurrence of significant neuronal cell death and its probable role in the developing human DN is reported for the first time.

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Configurational and Volumetric Changes of the Early Prenatal Human Cerebellar Dentate Nucleus

Cited by 6 publications

References 5 publications

Cytoarchitectural Development of the Human Dentate Nucleus: A Golgi Study

Cytoarchitectural Development of the Human Dentate Nucleus: A Golgi Study

Three-dimensional structure of the human cerebellar dentate nucleus: a computerized reconstruction study

Developing dentate nucleus in man: a qualitative and quantitative study

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