Confined and unconfined stress relaxation of cartilage: appropriateness of a transversely isotropic analysis

Bursać, Predrag; Obitz, Toby W.; Eisenberg, S.R.; Stamenović, Dimitrije

doi:10.1016/s0021-9290(99)00105-0

Cited by 107 publications

(84 citation statements)

References 18 publications

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“…It is reported in the literature that the out-of-plane Poisson's ratio (n 31 ) can be set to zero without compromising the accuracy of the model [29,30]. This is based on the observation that the equilibrium stress in the axial direction is the same in confined and unconfined compression, which implies that the radial stress is zero in confined compression.…”

Section: Analytical Formulationmentioning

confidence: 99%

“…The biphasic parameters for cartilage were estimated using the unconfined compression data for bovine cartilage from literature [30], which was characterized under similar testing conditions. A comparison was made between the load intensity responses predicted by the two models for the analysis of the quality of the fits obtained by each model.…”

Section: Biphasic Parameter Estimationmentioning

confidence: 99%

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Design and fabrication of 3D‐plotted polymeric scaffolds in functional tissue engineering

Yousefi¹,

Gauvin²,

Sun³

et al. 2007

Polymer Engineering & Sci

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Regenerating the load‐bearing tissues requires 3D scaffolds that balance the temporary mechanical function with the biological requirements. In functional tissue engineering, designing scaffolds with biomimetic mechanical properties could promote tissue ingrowth since the cells are sensitive to their local mechanical environment. This work aims to design scaffolds that mimic the mechanical response of the biological tissues under physiological loading conditions. Poly(L‐lactide) (PLLA) scaffolds with varying porosities and pore sizes were made by the 3D‐plotting technique. The scaffolds were tested under unconfined ramp compression to compare their stress profile under load with that of bovine cartilage. A comparison between the material parameters estimated for the scaffolds and for the bovine cartilage based on the biphasic theory enabled the definition of an optimum window for the porosity and pore size of these constructs. Moreover, the finite element prediction for the stress distribution inside the scaffolds, surrounded by the host cartilaginous tissue, demonstrated a negligible perturbation of the stress field at the site of implantation. The finite element modeling tools in combination with the developed methodology for optimal porosity/pore size determination can be used to improve the design of biomimetic scaffolds. POLYM. ENG. SCI., 47:608–618, 2007. © 2007 Society of Plastics Engineers.

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Section: Analytical Formulationmentioning

confidence: 99%

Section: Biphasic Parameter Estimationmentioning

confidence: 99%

Design and fabrication of 3D‐plotted polymeric scaffolds in functional tissue engineering

Yousefi¹,

Gauvin²,

Sun³

et al. 2007

Polymer Engineering & Sci

View full text Add to dashboard Cite

show abstract

“…As a next step, the isotropic biphasic solution [11,12] could also explain the time dependence of the cartilage mechanical behavior. In addition to the isotropic solution, transversely isotropic biphasic [13][14][15], poroviscoelastic [16], fibril reinforced poroelastic [17] solutions exist to improve the accuracy of the theoretical models to anticipate the cartilage response. However, none of these models consider the variations of mechanical properties of the articular cartilage through its depth.…”

Section: Introductionmentioning

confidence: 99%

A depth dependent transversely isotropic micromechanic model of articular cartilage

Elhamian

Alizadeh

Shokrieh

et al. 2015

J Mater Sci: Mater Med

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“…The higher the applied stress was, the stiffer the artC stiffness (Bursac et al 1999;Fortin et al 2000;Legare et al 2002). The knowledge of the strain dependent effect on the structural and functional alteration in artC is important for the assessment of artC and the development of theoretical models for compression and indentation tests.…”

Section: Introductionmentioning

confidence: 99%

Strain Dependence of Ultrasound Speed in Bovine Articular Cartilage Under Compression In Vitro

Ling

Zheng

Patil

2007

Ultrasound in Medicine & Biology

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The change of the ultrasound (US) speed in articular cartilage (artC) under applied strain conditions may induce some measurement errors of the mechanical properties of the artC during both indentation and compression tests using US. In this paper, the strain dependence of the US speed in bovine artC (n = 20) under compression in vitro was investigated by virtue of using a custom-made US-compression testing system. The US speeds of the artC at the instant after the compression and that after a period of stressrelaxation were estimated under the applied strain ranged from 0 % to 20 %. Moreover, the instantaneous modulus and the modulus after the stress-relaxation of the artC were measured and correlated with the US speeds. There was no significant difference (p > 0.05) between the US speeds at the instant after the compression and that after the stressrelaxation, even though there was a discrepancy between the instantaneous modulus and the modulus after stress-relaxation. The US speed was found to be highly correlated to the applied strain (r 2 = 0.98, p < 0.001) in a quadratic relation and changed by 7.8 % (from 1581 ± 36 m/s to 1671 ± 56 m/s) when the applied strain reached 20 %. The results revealed that the strain dependent effect on the US speed in artC should be considered when the US is deployed for the assessment of artC using the compression or indentation test.

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Confined and unconfined stress relaxation of cartilage: appropriateness of a transversely isotropic analysis

Cited by 107 publications

References 18 publications

Design and fabrication of 3D‐plotted polymeric scaffolds in functional tissue engineering

Design and fabrication of 3D‐plotted polymeric scaffolds in functional tissue engineering

A depth dependent transversely isotropic micromechanic model of articular cartilage

Strain Dependence of Ultrasound Speed in Bovine Articular Cartilage Under Compression In Vitro

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