We studied the scattering problem of two atoms with unequal mass, where one atom (atom α) is trapped in a quasi-one-dimensional (quasi-1D) tube and the other one (atom β) is localized by a 3D harmonic trap. We show that in such a system if atom α is much heavier than β, confinementinduced resonance (CIR) can appear when the 3D scattering length as of these two atoms is much smaller than the characteristic lengths (CLs) of the confinements, for either as > 0 or as < 0. This is quite different from the usual CIRs which occurs only when as is comparable with the CL of confinement. Moreover, the CIRs we find are broad enough that can serve as a tool for the control of effective inter-atomic interaction. We further show the mechanism of these CIRs via the Born-Oppenheimer approximation. Our results can be used for the realization of stronglyinteracting systems with ultracold atoms with weak 3D background interaction (i.e., small as), e.g., the realization of ultracold gases with strong spin-dependent interaction at zero magnetic field.