Confirmation of the Assignment of the Human Tartrate-Resistant Acid Phosphatase Gene (ACP5) to Chromosome 19

Prognostic significance of ACP5 expression in patients with lung adenocarcinoma

“…13,14 It belongs to the acid phosphatase family that catalyses the conversion of orthophosphoric monoester to alcohol and orthophosphate, and FIGU RE 2 High expression of ACP5 protein associated with poor OS in patinets with lung AD. 13,14 It belongs to the acid phosphatase family that catalyses the conversion of orthophosphoric monoester to alcohol and orthophosphate, and FIGU RE 2 High expression of ACP5 protein associated with poor OS in patinets with lung AD.…”

“…The human ACP5 gene maps to chromosome 19p13.2 and spans approximately 3 kb. 13,14 It belongs to the acid phosphatase family that catalyses the conversion of orthophosphoric monoester to alcohol and orthophosphate, and consists of an open reading frame of 975 bp that encodes an iron-containing glycoprotein of 35-37 kDa. [15][16][17] ACP5 is a di-iron metalloenzyme capable of hydrolyzing the phosphoester bond in numerous phosphorylated proteins.…”

Transcriptional profiling on chromosome 19p indicated frequent downregulation of ACP5 expression in hepatocellular carcinoma

“…The human ACP5 gene maps to chromosome 19p13.2 and spans approximately 3 kb. 25,26 It belongs to the acid phosphatase family that catalyses the conversion of orthophosphoric monoester to alcohol and orthophosphate, and consists of an open reading frame of 975 bp that encodes an iron-containing glycoprotein of 35-37 kDa. [27][28][29] While ACP5 is normally highly expressed in the human liver (NormalTissueAtlas; http://genomewww.stanford.edu/cgi-bin/source/), a phenomenon of acid phosphatase deficiency has been described in HCC tumor cells.…”

Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase

“…Of particular interest was the observation that plants appear to contain at least three types of PAPs, a dimeric form consisting of two identical polypeptides of ∼55 kDa, a dimeric form consisting of two different subunits, and an as of yet uncharacterized ∼35 kDa form homologous to mammalian enzymes (Schenk et al, 2000b;Bozzo et al, 2002). In contrast, only a single low molecular weight isoform has been detected in mammalian genomes (Grimes et al, 1993;Ling and Roberts, 1993;Leach et al, 1994). No PAPs have yet been reported from Drosophila or other insect genomes (Oddie et al, 2000).…”