Confirming quantitative trait loci for aflatoxin resistance from Mp313E in different genetic backgrounds

Willcox, Martha C.; Davis, Gregory L.; Warburton, Marilyn L.; Windham, Gary L.; Abbas, Hamed K.; Betrán, Javier; Holland, James B.; Williams, W. Paul

doi:10.1007/s11032-012-9821-9

Cited by 47 publications

(48 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eight QTL mapping experiments on A. flavus or aflatoxin resistance [35][36][37][38][39][40][41][42] and one additional on ear rot due to A. flavus [43] have been published to date. Most of these QTL studies have reported multiple QTL, most of which have been found in only one environment, and the majority of the QTL each account for less than 5% of the phenotypic variation observed in the population and the environment in which it was measured.…”

Section: Mapped Aflatoxin Resistance Qtlmentioning

confidence: 99%

Aflatoxin Resistance in Maize: What Have We Learned Lately?

Warburton

Williams

2014

Advances in Botany

Self Cite

View full text Add to dashboard Cite

Aflatoxin contamination of maize grain is a huge economic and health problem, causing death and increased disease burden in much of the developing world and income loss in the developed world. Despite the gravity of the problem, deployable solutions are still being sought. In the past 15 years, much progress has been made in creating resistant maize inbred lines; mapping of genetic factors associated with resistance; and identifying possible resistance mechanisms. This review highlights this progress, most of which has occurred since the last time a review was published on this topic. Many of the needs highlighted in the last reviews have been addressed, and several solutions, taken together, can now greatly reduce the aflatoxin problem in maize grain. Continued research will soon lead to further solutions, which promise to further reduce and even eliminate the problem completely.

show abstract

Section: Mapped Aflatoxin Resistance Qtlmentioning

confidence: 99%

Aflatoxin Resistance in Maize: What Have We Learned Lately?

Warburton

Williams

2014

Advances in Botany

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ear rot was the subject of a recent meta-analysis (Xiang et al, 2010), but the study did not include data for resistance to mycotoxin accumulation, and we are not aware of prior studies reporting meta-analysis of aflatoxin resistance. With the recent publication of three new QTL mapping studies on resistance to aflatoxin accumulation and an additional study presented here, the number of available studies has increased, making a metaanalysis of this trait more relevant (Mayfield et al, 2011;Warburton et al, 2010;Willcox et al, 2013).…”

Section: Fungal Isolate Inoculation Procedures and Phenotypingmentioning

confidence: 99%

“…The largest of these (representing the most QTL) was mqtl5 on chromosome 4, which was formed by four QTL for resistance to aflatoxin accumulation (Supplemental Table S3). These included qbAFL4.08, located near marker PHM3637 in maize bin 4.08 in our stepwise regression analysis, and QTL from populations Mp313E × B73 (Brooks et al, 2005), B73O2/O2 × CML616 (Mayfield et al, 2011), and Mp313E × Va35 (Willcox et al, 2013).…”

Section: Quantitative Trait Loci Meta-analysismentioning

confidence: 99%

Quantitative Trait Loci Influencing Mycotoxin Contamination of Maize: Analysis by Linkage Mapping, Characterization of Near‐Isogenic Lines, and Meta‐Analysis

et al. 2014

Self Cite

View full text Add to dashboard Cite

Mycotoxin contamination of maize (Zea mays L.) exposes people to grave health consequences in subsistence agricultural settings and to economical losses in quality‐regulated markets. Genetic variation for resistance to aflatoxin accumulation in maize has been reported in many studies. Resistance can act at multiple steps at which there is fungal–plant interaction. In this study, we report the identification and mapping of quantitative trait loci (QTL) for multiple traits or components of resistance to Aspergillus flavus using different genetic tools and resources. For QTL mapping, we used a B73 × CML322 population of recombinant inbred lines. Ten QTL were found using two QTL mapping methods, six of which were located on the same chromosome segments using both approaches. These QTL were located in maize bins 4.08, 4.09, 8.02, 8.03, 10.06 and 10.07. Various sources of near‐isogenic lines (NILs) for selected loci were tested. The resistance QTL located in bin 4.08 was confirmed using a NIL pair. Finally, we conducted a meta‐analysis of QTL using data from 12 populations in which resistance to Aspergillus, Fusarium, or Giberella ear rots has been mapped. This meta‐analysis indicated that the QTL in bin 4.08 has been reported in four mapping populations. Overall, we found evidence for significant QTL × year interactions and that QTL were distributed in a manner consistent with an infinitesimal model. The largest‐effect QTL, located in bin 4.08, is a good candidate for further characterization and use.

show abstract

“…Therefore, recent breeding studies focused on the discovery and characterization of quantitative trait loci (QTL) for aflatoxin resistance were forced to consider the environment in obtaining phenotypic data, and have faced numerous challenges in identifying consistent QTL for aflatoxin resistance. For example, Willcox et al [59] utilized an F 2 mapping population derived from Mp313E × Va35 (resistant × susceptible) to identify 20 QTLs with combined phenotypic variance explained (PVE) of 22-43%. However, when the mapping populations were grown in multiple environments, only 11 QTLs were found to be consistent with a combined PVE of 2.4-9.5%.…”

Section: Qtl Discoverymentioning

confidence: 99%

Resistance to Aspergillus flavus in maize and peanut: Molecular biology, breeding, environmental stress, and future perspectives

et al. 2015

View full text Add to dashboard Cite

The colonization of maize (Zea mays L.) and peanut (Arachis hypogaea L.) by the fungal pathogen Aspergillus flavus results in the contamination of kernels with carcinogenic mycotoxins known as aflatoxins leading to economic losses and potential health threats to humans. The regulation of aflatoxin biosynthesis in various Aspergillus spp. has been extensively studied, and has been shown to be related to oxidative stress responses. Given that environmental stresses such as drought and heat stress result in the accumulation of reactive oxygen species (ROS) within host plant tissues, host-derived ROS may play an important role in cross-kingdom communication between host plants and A. flavus. Recent technological advances in plant breeding have provided the tools necessary to study and apply knowledge derived from metabolomic, proteomic, and transcriptomic studies in the context of productive breeding populations. Here, we review the current understanding of the potential roles of environmental stress, ROS, and aflatoxin in the interaction between A.flavus and its host plants, and the current status in molecular breeding and marker discovery for resistance to A. flavus colonization and aflatoxin contamination in maize and peanut. We will also propose future directions and a working model for continuing research efforts linking environmental stress tolerance and aflatoxin contamination resistance in maize and peanut.

show abstract

Confirming quantitative trait loci for aflatoxin resistance from Mp313E in different genetic backgrounds

Cited by 47 publications

References 28 publications

Aflatoxin Resistance in Maize: What Have We Learned Lately?

Aflatoxin Resistance in Maize: What Have We Learned Lately?

Quantitative Trait Loci Influencing Mycotoxin Contamination of Maize: Analysis by Linkage Mapping, Characterization of Near‐Isogenic Lines, and Meta‐Analysis

Resistance to Aspergillus flavus in maize and peanut: Molecular biology, breeding, environmental stress, and future perspectives

Contact Info

Product

Resources

About