Conflicting results of non-invasive methods for detection of Helicobacter pylori infection in children with celiac disease - a preliminary study.

Józefczuk, Jan; Mądry, Edyta; Nowak, Jan Krzysztof; Walkowiak, Marcin Piotr; Łochocka, Klaudia; Banasiewicz, Tomasz; Pławski, Andrzej; Kwiecień, Jarosław; Walkowiak, Jarosław

doi:10.18388/abp.2015_1088

Cited by 5 publications

(8 citation statements)

References 17 publications

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“…However, further studies to prove this hypothesis are requested due to some limitations of this study. Jozefczuk et al . suggested that celiac disease may increase the risk of divergent results of noninvasive tests for H. pylori in children due to altered gut motility, superficial gastritis, and/or loose stools, however this has not been proven.…”

Section: Diagnosismentioning

confidence: 99%

Helicobacter pylori in children

2016

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Helicobacter pylori infection in early childhood may differ in many aspects compared to infection in adulthood: the immune response in the gut, the type and prevalence of complications within and outside the stomach, and the impact on long-term health. In high prevalence countries, transient infections seem to be common in infants and toddlers, and the consequences of this phenomenon on the short- and long-term immune response are still unclear. Other controversial issues are related to the question of which H. pylori-infected children benefit from treatment and which is the best regimen to eradicate the infection in the presence of a worldwide increasing antibiotic resistance. The first large-scale randomized placebo-controlled vaccination trial in schoolchildren indicates that prevention of the infection may be possible.

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Section: Diagnosismentioning

confidence: 99%

Helicobacter pylori in children

2016

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“…Therefore, the full-texts of 92 remained articles were completely evaluated. Finally, 26 studies were included in the systematic review and also meta-analysis (kappa (κ) = 0.84) [11,[13][14][15][16][17][18]21,[24][25][26][27][39][40][41][42][43][44][45][46][47][48][49][50][51][52], and the others were excluded due to a reason mentioned in Fig 1 (Fig 1). In the end, there was no suitable cohort study in the included studies.…”

Section: Search Resultsmentioning

confidence: 99%

“…Most studies PLOS ONE were from Turkey (N = 6) [15][16][17][18]51,52] and Italy (N = 5) [11,27,44,45,48]. Some studies had been performed only on children [13,[15][16][17]21,44,47,51,52] or adults [18,25,27,39,43,45,48], the others evaluated both age groups [11,14,42,49,50]. Table 1 shows the details of the included articles.…”

Section: Characteristics Of the Included Articlesmentioning

confidence: 99%

A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease

et al. 2021

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Background and objectives Based on some previous observational studies, there is a theory that suggests a potential relationship between Helicobacter pylori (H. pylori) colonization and celiac disease (CeD); however, the type of this relationship is still controversial. Therefore, we aimed to conduct a systematic review and meta-analysis to explore all related primary studies to find any possible association between CeD and human H. pylori colonization. Data sources Studies were systematically searched and collected from four databases and different types of gray literature to cover all available evidence. After screening, the quality and risk of bias assessment of the selected articles were evaluated. Synthesis methods Meta-analysis calculated pooled odds ratio (OR) on the extracted data. Furthermore, heterogeneity, sensitivity, subgroups, and publication bias analyses were assessed. Results Twenty-six studies were included in this systematic review, with a total of 6001 cases and 135512 control people. The results of meta-analysis on 26 studies showed a significant and negative association between H. pylori colonization and CeD (pooled OR = 0.56; 95% CI = 0.45–0.70; P < 0.001), with no publication bias (P = 0.825). The L’Abbé plots also showed a trend of having more H. pylori colonization in the control group. Among subgroups, ORs were notably different only when the data were stratified by continents or risk of bias; however, subgroup analysis could not determine the source of heterogeneity. Conclusions According to the meta-analysis, this negative association might imply a mild protective role of H. pylori against celiac disease. Although this negative association is not strong, it is statistically significant and should be further considered. Further investigations in both molecular and clinic fields with proper methodology and more detailed information are needed to discover more evidence and underlying mechanisms to clear the interactive aspects of H. pylori colonization in CeD patients. Systematic review registration number (PROSPERO) CRD42020167730 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=167730.

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“…BMI was recalculated for patients younger than 18 years according to International Obesity Task Force values (BMI-IOTF corrected) [12]. The presence of HP was assessed using the 13 C isotope-labelled UBT. The 13 CO 2 / 12 CO 2 ratio measurement was carried out using a 13 C-infrared isotope analyser system (IRIS, Wagner Analysen Technik, Bremen, Germany) as described earlier [13,14].…”

Section: Methodsmentioning

confidence: 99%

Helicobacter pylori Infection in Children with Phenylketonuria Does Not Depend on Metabolic Control and Is Not More Frequent Than in Healthy Subjects—A Cross-Sectional Study

et al. 2021

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In a small preliminary study, phenylketonuria and poor metabolic control were suggested as risk factors for Helicobacter pylori infection in children as detected with an antigen stool test. We aimed to determine Helicobacter pylori prevalence in an adequately sized group of individuals with phenylketonuria and healthy subjects using the standard gold test (urea breath test). Further, we correlated Helicobacter pylori infection with metabolic control. The study comprised 103 individuals with phenylketonuria and 103 healthy subjects on whom a 13C urea breath test was performed. Blood phenylalanine levels in the preceding year were analysed. The infection rate did not differ between individuals with phenylketonuria and healthy subjects (10.7% vs 15.5%; p = 0.41). The frequency of testing and phenylalanine concentrations of Helicobacter pylori-positive and Helicobacter pylori-negative patients with phenylketonuria did not differ (p = 0.92 and p = 0.54, respectively). No associations were detected for body mass index or metabolic control. Forward stepwise regression models revealed that age (p = 0.0009–0.0016) was the only independent correlate of Helicobacter pylori infection with a relatively low fraction of the variability of the condition being explained (adjR2 = 0.0721–0.0754; model p = 0.020–0.023). In conclusion, Helicobacter pylori infection in phenylketonuria is not more frequent than in the general population. Moreover, it does not depend on metabolic control.

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Conflicting results of non-invasive methods for detection of Helicobacter pylori infection in children with celiac disease - a preliminary study.

Cited by 5 publications

References 17 publications

Helicobacter pylori in children

Helicobacter pylori in children

A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease

Helicobacter pylori Infection in Children with Phenylketonuria Does Not Depend on Metabolic Control and Is Not More Frequent Than in Healthy Subjects—A Cross-Sectional Study

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