Conformation dependency of antibody to poly(L-tyrosyl-L-glutamyl-L-alanylglycyl)glycine-l-14C ethyl ester

Low Temperature Photoluminescence and Leakage Current Characteristics of InAs-GaSb Superlattice Photodiodes

“…This data suggests that structures C and A have a higher density of the interface traps, which are responsible for trap-assisted tunneling than structure B. Note that photoexcited holes in the SL region will undergo drift/diffusion to the p-GaSb/n-SL interface where trap-assisted tunneling of electrons from the GaSb valence band into holes at the interface enhances the transport of holes across the p-GaSb /n-SL interface (7). Structure C's quality and the associated strong valence band mixing suggest that it has a larger hole mobility over the range 40-80 K than the other structures.…”

“…The InAs-GaSb SL is composed of thin alternating InAs and GaSb layers that utilize quantum confinement to vary its bandgap by varying the SL periodicity, while the strained InAs-GaInSb SL employs quantum confinement and strain effects to vary its bandgap and optical characteristics. Intensive research over the past two decades has led to significant progress (3)(4)(5)(6)(7)(8) in understanding the characteristics of type II SL photodiodes. However, type II SL photodetectors have not realized their predicted performance (2, 9) expectations, which are based on the intrinsic characteristics of type II GaSb/InAs SLs.…”

Antigenic determinants of the polypeptide, poly(L-tyrosyl-L-glutamyl-L-alanylglycyl)glycine-1-14C ethyl ester

“…An interesting corollary from these experiments is the apparent similarity in conformation of the small peptide (Tyr-Glu-Ala-GlyJiGly (5) and the model antigen 1. As an explanation, it is possible that the conformation of the antibodies helps the heptadecapeptide 5 to assume a conformation that is most conducive for coverage of the antibody active site.…”

“…Another approach that was considered in order to elucidate the spacial requirements of the antigenic determinants of the polypeptide, poly(Tyr-Glu-Ala-Gly)Gly-l-14C ethyl ester (1), was to find the smallest oligopeptide which would affect the precipitin reaction between the model polypeptide and its antisera. For this purpose we wish to report the synthesis and immunochemical properties of the following oligopeptides: Ala-Gly(Tyr-Glu-Ala-GlybGly (3), Glu-Ala-Gly(Tyr-Glu-Ala-Gly)3Gly (4), and (Tyr-Glu-Ala-Gly)4Gly (5).…”

“…The polymerization was performed in the presence of a preformed monomer since this has been shown to produce linear high molecular weight polypeptides. [1][2][3][4][5][6][7][8][9][10][11]17 Following this established procedure, the insoluble polymer, poly(O-tert-butyl-L-tyrosyl-7-tertbutyl-L-glutamyl-L-alanyl-d-alanyl)glycine methyl ester, was prepared, from which the protecting terf-butyl groups were removed by use of 90% trifluoroacetic acid to yield poly(L-tyrosyl-L-glutamyl-L-alanyl-/3-alanyl)glycine methyl ester (2). After extensive dialysis, the polymer 2 was fractionated by successive diafiltration through Diaflo membranes into four different molecular weight fractions: 5 x 104; 2-5 x 104; 1-2 x 104; and 1 x 104.…”