Conformation transition of silk fibroin induced by blending chitosan

Chen, Xin; Li, Wenjun; Yu, Tao

doi:10.1002/(sici)1099-0488(199710)35:14<2293::aid-polb9>3.0.co;2-x

Cited by 97 publications

(72 citation statements)

References 2 publications

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“…According to the literature, when SF was mixed with other natural polymers containing hydroxyl groups (cellulose, alginate, heparin, and others), cross-linking between the polymers may benefit the conformational transition of SF [30]. Chen et al (1997) performed structural analyzes on SF and chitosan films [32]. Authors found that SF exhibited β-sheet structure, indicating that hydrogen bonding was formed between SF and chitosan in the blend films.…”

Section: Chemical Characterizationmentioning

confidence: 99%

Synthesis and Properties of Silk Fibroin/Konjac Glucomannan Blend Beads

et al. 2018

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Silk fibroin (SF) and konjac glucomannan (KGM) are promising materials in the biomedical field due to their low toxicity, biocompatibility, biodegradability and low immune response. Beads of these natural polymers are interesting scaffolds for biomedical applications, but their fabrication is a challenge due to their low stability and the necessary adaptation of their chemical and mechanical properties to be successfully applied. In that sense, this study aimed to synthesize a blend of silk fibroin and konjac glucomannan (SF/KGM) in the form of porous beads obtained through dripping into liquid nitrogen, with a post-treatment using ethanol. Intermolecular hydrogen bonds promoted the integration of SF and KGM. Treated beads showed higher porous size, crystallinity, and stability than untreated beads. Characterization analyses by Fourier-transform infrared spectroscopy (FTIR), thermogravimetric (TGA), and X-ray diffraction (XDR) evidenced that ethanol treatment allows a conformational transition from silk I to silk II in SF and an increase in the KGM deacetylation. Those chemical changes significantly enhanced the mechanical resistance of SF/KGM beads in comparison to pure SF and KGM beads. Moreover, samples showed cytocompatibility with HaCaT and BALB/c 3T3 cells.

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Section: Chemical Characterizationmentioning

confidence: 99%

Synthesis and Properties of Silk Fibroin/Konjac Glucomannan Blend Beads

et al. 2018

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“…The amount of drug unentrapped in the supernatant was calculated. The amount of drug entrapped was determined by subtracting amounts of free, uninterrupted drug from the total amount of ceftriaxone sodium taken [10][11][12].…”

Section: Entrapment Efficiency (Ee) Of Nanoparticlesmentioning

confidence: 99%

Preparation and Characterization of Ceftriaxone Sodium Encapsulated Chitosan Nanoparticles

Manimekalai

Dhanalakshmi²,

Manavalan³

2017

Int J App Pharm

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Objective: The objective of this study was to prepare ceftriaxone sodium chitosan nanoparticles (CS-NP) from different drug and polymer ratios and analyze their physicochemical characteristics.Methods: Ceftriaxone sodium loaded chitosan nanoparticles were prepared using chitosan as a polymer and tri sodium polyphosphate (TPP) as cross linking agent by ionic cross linking and coacervation with the aid of sonication. Various trials have been carried out for the confirmation of nanoformulation. Parameters such as the zeta potential, polydispersity, particle size, entrapment efficiency, in vitro drug release Thermo gravimetric analysis and scanning electron microscope of the nanoparticles were assessed for confirmation of nanoformulation. Results:The formulated nanoparticles showed mean particle size, polydispersity index and zeta potential to be 183.1±8.42 nm, 0.212±0.05, +38.5±1.6 mV respectively and the drug loading was found to be 46.42±10 %. In vitro drug release was showed a biphasic release pattern with initial burst release followed by sustained release of formulated nanoparticles. The cumulative percentage of drug release was about 83.08 %. Conclusion:Formulation F2 was found to be the best formulation with a higher cumulative percentage of drug release. Modified ionic gelation method can be utilized for the development of chitosan nanoparticles of ceftriaxone sodium. Polymer and crosslinking agent concentrations and sonication time are rate-limiting factors for the development of the optimized formulation. The chitosan nanoparticles developed would be capable of sustained delivery of ceftriaxone sodium.

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“…The first peak for chitosan at 898 cm -1 is assigned to the saccharide structure [16] . For the chitosan-PEO 100K blend IR spectra, the peak position is the same.…”

Section: Fourier Transform Infra Red (Ftir)mentioning

confidence: 99%

Characterization of Chitosan-poly (Ethylene Oxide) Blends as Haemodialysis Membrane

Nasir¹,

Zain²,

Raha³

et al. 2005

American J. of Applied Sciences

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Blend membranes of chitosan and poly (ethylene oxide) with different molecular weights of 100,000 and 600,000 were prepared by the solution cast technique. The Chitosan-PEO blend membranes were produced to study their water adsorptions capacity and characteristics of the haemodialysis membrane application. An increase in the water adsorption capacity of chitosan-PEO blend membranes compared to the pure chitosan was due to the porous structure as evident from the scanning electron micrograph. Addition of PEO with higher molecular weight had reduced the percentage of water adsorption of the chitosan-PEO blend membranes. XRD results revealed that chitosan-PEO blend membrane with higher water adsorption ability shows lesser degree of amorphosity. Intermolecular interactions between chitosan and higher molecular PEO chains in the blend contributed to important alteration in chitosan structure as observed in the infrared spectroscopy which lessens the permeability of the membrane.

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Conformation transition of silk fibroin induced by blending chitosan

Cited by 97 publications

References 2 publications

Synthesis and Properties of Silk Fibroin/Konjac Glucomannan Blend Beads

Synthesis and Properties of Silk Fibroin/Konjac Glucomannan Blend Beads

Preparation and Characterization of Ceftriaxone Sodium Encapsulated Chitosan Nanoparticles

Characterization of Chitosan-poly (Ethylene Oxide) Blends as Haemodialysis Membrane

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