Conformational study of some N-acyl-2r,6c-diphenylpiperidin-4-one oximes using NMR spectra

Synthesis and structural study of 3t-isopropyl-2r,6c-diphenyl-4-oxopiperidinium nitrate and N-benzoyl-3t-isopropyl-2r,6c-diphenylpiperidin-4-one oxime

“…In the previous study on N-benzoylpiperidine-4-one oximes [8] the relative population of the three possible conformations CA, B1 and B2 (Fig. 10.…”

“…10. ) were calculated for N-benzoyl-2r,6c-diphenylpiperidine-4-one oxime (8) and N-benzoyl-3t-methyl-2r,6c-diphenylpiperidine-4-one oxime (9), from the observed vicinal constants between the trans protons about C(2)-C(3) and C(5)-C(6) bonds. The probable values of the vicinal coupling constants for the three conformations were taken from suitable model compounds.…”

“…Single crystal X-ray crystallography is used for the determination of structure and conformation in the solid state whereas NMR spectroscopy is used for such a determination in solution. Several conformational studies have been made on 2r,6c-diphenylpiperidine-4-ones and their derivatives [1][2][3][4][5][6][7][8] using NMR spectroscopy. The crystal structure of 3t-isopropyl-2r,6c-diphenylpiperidin-4-one (1) has been reported [9].…”

“…Though in the conformational study on N-benzoylpiperidine-4-ones [7] N-benzoyl-3t-isopropyl-2r,6c-diphenylpiperidin-4-one (3) has been included, in the conformational study on N-acylpiperidin-4-one oxmies [8] the oxime (4) of 3 has not been included. In the present work the conformation of N-benzoyl-3t-isopropyl-2r,6c-diphenylpiperidin-4-one oxime (4) has been investigated in the solid state and in solution.…”

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“…Such fundamental manifestation of life as the provision of energy, transmission of nerve impulses, sight, metabolisms and transfer of genetic information are all based on chemical interactions involving participation of many heterocyclic compounds such as vitamins, enzymes. The present study was designed to examine the effect of chloro substituted cyanoacetyl hydrazones on cell divisions in the root meristems of allium cepa to reveal the cytotoxic Preparation of S1, S2 and S3 3-methyl-2,6-diphenylpiperidin-4-one was prepared by adopting the literature method [1][2][3][4][5][6].…”