Conformations of poly(allylamine hydrochloride) in electrolyte solutions: Experimental measurements and theoretical modeling

Jachimska, Barbara; Jasiński, Tadeusz; Warszyński, Piotr; Adamczyk, Zbǐgniew

doi:10.1016/j.colsurfa.2009.11.012

Cited by 63 publications

(69 citation statements)

References 21 publications

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“…For increasing ionic strength, decreasing of the contour implies the folding of the molecule, becoming 3.5 nm for I = 0.03 mol/L, 2.9 nm for I = 0.19 mol/L, and 2.5 nm for I = 0.33 mol/L. A similar behavior was predicted in the simulations of Adamczyk [20,21] , who studied conformations of poly(allylamine hydrochloride) in electrolyte solutions. For the lower ionic strength, the polyelectrolyte chain becomes more extended.…”

Section: Size and Shapesupporting

confidence: 65%

“…The R H and [η] for HM-PAM and HM-HPAM molecules can be calculated through the following equations [20,21] . For the bent spheroid,…”

Section: Size and Shapementioning

confidence: 99%

“…That parameter also facilitates the interpretation of dynamic viscosity measurements in terms of the hydrodynamic theory. The L ef was calculated as a value of the distance between the surfaces of two outermost atoms of the molecule averaged at the fluctuating equilibrium state [20,21] . The procedure of the calculations of [η] of HM-PAM and HM-HPAM is explained in the next part of the paper.…”

Section: Size and Shapementioning

confidence: 99%

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Dynamics simulation on the associative properties of amphiphilic functional monomer modified polyacrylamide copolymers

et al. 2015

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A kind of amphiphilic functional monomer was selected to modify polyacrylamide (PAM) or partially hydrolyzed polyacrylamide (HPAM). The relative properties of the modified polyacrylamide (HM-PAM) and modified partially hydrolyzed polyacrylamide (HM-HPAM) such as radius of gyration (R g ), hydrodynamic radius (R H ), and radial distribution functions (RDFs) have been studied to find the intrinsic relation between the microstructure of the polymer chain and the intrinsic viscosities with changing the amount of modified monomers from 1% to 4%. The simulation results show that, compared to HPAM, HM-HPAM has a better performance in increasing viscosity when the percentage of modified monomers is 2% and has a stronger salt tolerance when the modified monomers is 4%. Furthermore, a complex hydrogen bonding network was revealed with the analysis of radial distribution functions (RDFs) and the pair correlation function was used to investigate the diffusivity of Na + and carbon atoms in the COO -group.

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Section: Size and Shapesupporting

confidence: 65%

“…The R H and [η] for HM-PAM and HM-HPAM molecules can be calculated through the following equations [20,21] . For the bent spheroid,…”

Section: Size and Shapementioning

confidence: 99%

Section: Size and Shapementioning

confidence: 99%

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Dynamics simulation on the associative properties of amphiphilic functional monomer modified polyacrylamide copolymers

et al. 2015

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“…In the second step the weakly charged polycation poly(allylamine hydrochloride) 17 was adsorbed as the first layer of the forthcoming multilayer on silica particles. Again, the zeta potential of the formed SiO 2 /PAH particles was measured by means of the electrophoretic light scattering instrument and the results are shown in Figure 2.…”

Section: Formation Of Pah/pss/pah Multilayer On Silica Particlesmentioning

confidence: 99%

“…On the other hand, the adsorption of polyelectrolytes on metal oxides (which can be compared to the adsorption of one polyelectrolyte layer) is commonly studied and the experimental results very often include zeta potential measurements. [13][14][15][16][17] The aim of presented study is, therefore, to examine the formation of a polyelectrolyte multilayer on silica particles and the adsorption of a protein on already formed multilayer by means of electrokinetic and spectrophotometric measurements as the function of pH, as well as to compare the obtained results with previously obtained ones on flat surfaces. Polyelectrolyte multilayers were formed by the alternate adsorption of a weakly charged polyelectrolyte poly(allylamine hydrochloride) and a strongly charged polyelectrolyte poly(sodium 4-styrenesulfonate) on which the protein bovine serum albumin (BSA) was additionally adsorbed.…”

Section: Introductionmentioning

confidence: 99%

Electrokinetic Study of Bovine Serum Albumin Adsorption on Previously Formed PAH/PSS Multilayer

Đapić¹,

Kovačević²

2011

Croat. Chem. Acta

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Abstract. Layer-by-layer structures (e.g. polyelectrolyte multilayers and protein-polyelectrolyte multilayers) play a very important role in surface modification processes. In the present study, electrokinetic measurements were applied for the investigation of poly(allylamine hydrochloride)/poly(sodium 4-styrenesulphonate) (PAH/PSS) multilayer formation, with PAH being a terminal layer, as a function of pH. Additionally, the effect of supporting electrolyte (KCl) concentration on multilayer formation was tested. Silica particles were used as the solid substrate. Furthermore, the adsorption of bovine serum albumin (BSA) on previously formed multilayer was examined as a function of pH and BSA concentration. It was confirmed that the electrokinetic measurements are suitable for monitoring the formation of various multilayers. In all investigated systems the process of multilayer formation was found to depend on conditions (ionic strength and pH) under which the multilayer was formed. Moreover, in the case of BSA, the adsorption on previously formed multilayer BSA concentration also plays a significant role. (doi: 10.5562/cca1822)

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Synthesis of strong polycations with improved biological properties

Wytrwał-Sarna

Koczurkiewicz

Wójcik

et al. 2013

J Biomedical Materials Res

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Poly(allylamine hydrochloride) (PAH) has found many applications both in biotechnology and biomedical fields. However, its high toxicity toward various mammalian cells significantly limits its effective usage. This study focuses on improving the biological properties of PAH by its modification to strong polyelectrolytes. The strong polycations were prepared by the direct quaternization of PAH amino groups or by the attachment of glycidyltrimethylammonium chloride to these groups. The biological properties, such as cytotoxicity toward human skin fibroblasts (HSFs), proliferation and migration of the cells on a polymeric surface, and antibacterial activities against two pathogenic bacteria, Staphylococcus aureus and Escherichia coli, were determined. All the modified polyelectrolytes are considerably less toxic to HSFs as compared to PAH. Moreover, the directly quaternized polycations are stronger biocides against S. aureus than the parent polymer. Contrary to PAH, thin films of the modified polyelectrolytes improve or do not affect HSFs proliferation and can stimulate cell migration into the wound, as was demonstrated using an in vitro model. The relationship between the structure of the modified polymers (amount and localization of the quaternary ammonium groups) and the biological activity is discussed. Due to the improved biological properties, the obtained polycations may be potentially useful for a variety of biotechnological and biomedical applications.

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Conformations of poly(allylamine hydrochloride) in electrolyte solutions: Experimental measurements and theoretical modeling

Cited by 63 publications

References 21 publications

Dynamics simulation on the associative properties of amphiphilic functional monomer modified polyacrylamide copolymers

Dynamics simulation on the associative properties of amphiphilic functional monomer modified polyacrylamide copolymers

Electrokinetic Study of Bovine Serum Albumin Adsorption on Previously Formed PAH/PSS Multilayer

Synthesis of strong polycations with improved biological properties

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