Confounding Issues in Cancer Progress—The Impact of Investor Requirements on Senior Management Compensation and Regulatory Decisions: Tivozanib and Aveo Pharmaceuticals

Babiarz, Josephine C.; Melaragni, Francis; Kerr, Stephen J.; Kuchimanchi, Pranati

doi:10.1177/2168479015572372

Cited by 2 publications

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“…Adhesion and invasion are essential during the process of lung cancer cell metastasis ( 15 , 26 ). The development of metastasis is the primary cause of the low survival rates in patients with cancer ( 27 , 28 ). In the present study, THSG was demonstrated to significantly inhibit lung cancer cell viability, adhesion and invasion.…”

Section: Discussionmentioning

confidence: 99%

2,3,5,4-tetrahydroxy diphenylethylene-2-O-glucoside inhibits the adhesion and invasion of A549 human lung cancer cells

Zhu

Wang

et al. 2017

Molecular Medicine Reports

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Lung cancer is considered to be a serious disease that poses a significant threat to human health. 2,3,5,4-tetrahydroxy diphenylethylene-2-O-glucoside (THSG) is a bioactive compound derived from Polygonum multiflorum Thunb. That has been demonstrated to possess antioxidative, anti-inflammatory and antitumor activities. However, little is currently known regarding the potential anticancer effects of this compound in lung cancer. Therefore, the present study aimed to investigate the effects of THSG on the adhesion and invasion of A549 human lung cancer cells in vitro, and to identify the putative mechanisms involved. Cell Counting kit-8 assay was performed to determine A549 cell viability following treatment with various doses (0, 5, 10, 25, 50, 100, 150 and 200 µM) of THSG for 12, 24 and 48 h. In addition, cell adhesion and invasion were determined following treatment of A549 cells with 0, 10, 25 or 50 µM THSG for 1, 2 or 3 h, respectively. Reverse transcription-quantitative polymerase chain reaction analysis was performed to examine the mRNA expression levels of Snail, E-cadherin, vimentin, matrix metalloproteinase (MMP) 2 and MMP9 following THSG treatment for 12 h. Western blot analysis was conducted to detect the protein expression levels of Snail, E-cadherin, vimentin, MMP2 and MMP9 following THSG treatment for 24 h. Treatment with THSG (10, 25 and 50 µM) significantly suppressed the adhesion and invasion of A549 human lung cancer cells in a dose-dependent manner. In addition, the mRNA and protein expression levels of adhesion and invasion-associated factors were decreased significantly in A549 cells treated with THSG. In conclusion, THSG effectively suppressed the adhesion and invasion of human lung cancer cells potentially by inhibiting the expression of adhesion and invasion-related genes.

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Section: Discussionmentioning

confidence: 99%

2,3,5,4-tetrahydroxy diphenylethylene-2-O-glucoside inhibits the adhesion and invasion of A549 human lung cancer cells

Zhu

Wang

et al. 2017

Molecular Medicine Reports

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Corporate governance and the environment in the health sector: Systematic literature review

Marques

Serrasqueiro

Nogueira

2020

JGR

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This study aims to explore the different forms of corporate governance in the health sector, how they interact, and analyze the emerging research trend through a systematic literature review (SLR) in the period 2015-2019. The Scopus and ISI Web of Science databases were used to select the 167 articles analyzed. The coverage of corporate governance research was centred on adapting the PRISMA analysis, highlighting the environment which corporate governance belongs to and analysis of the co-occurrence of the keywords used in the studies. Through Grounded theory, a conceptual model was developed, emphasizing the main attributes that influence governance at the macro-, meso- and micro-levels, in the health area, and raising a future agenda for future research in this area: (1) quality of health care, (2) corporate social responsibility in health, (3) health risk management and (4) global health governance. The results of this research aim to guide governments towards emerging regulatory trends, warning about the risks of the impact of corporate governance on health, or the lack of it, on the quality of services. Analysis of the quality of health care is intrinsically related to the environment, although this aspect has received little attention from researchers.

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Confounding Issues in Cancer Progress—The Impact of Investor Requirements on Senior Management Compensation and Regulatory Decisions: Tivozanib and Aveo Pharmaceuticals

Cited by 2 publications

References 1 publication

2,3,5,4-tetrahydroxy diphenylethylene-2-O-glucoside inhibits the adhesion and invasion of A549 human lung cancer cells

2,3,5,4-tetrahydroxy diphenylethylene-2-O-glucoside inhibits the adhesion and invasion of A549 human lung cancer cells

Corporate governance and the environment in the health sector: Systematic literature review

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